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Carol, I'm glad someone answered by saying that if you feel fine your meds must be fine for you. That is a question that really only you can answer. Parkinson's is a very individualized disease. It would probably be very difficult to find two PWP who take the same medication at the same time and have same reaction. If your meds let your body feel and act like a "normal" person than they are fine for you at that time. You will know when they need to be changed. And maybe you've already discovered that a number of things can affect the meds and throw things off for a short time - stress, of mind or body ( even just a cold), hormones, and if protein bothers you stick to a low protein, low fat diet. Unless you are bothered by nausea, try not to eat 45 minutes to an hour before and after taking Sinemet. And here's a plug for Kathrynne Holden - her nutrition handbook "Eat well, Stay well with Parkinson's Disease" is very informative. She also authored the NPF booklet "Nutrition Matters" which you can receive at no cost from NPF (1-800-327-4545). Sharon H