At 17:39 6-12-99 -0500, you wrote:
>>>>
TimesIda,0606,0000,0000
Very interesting. Didn't know that. Now how do I get off sinemet, and is that at all possible after taking it for
12 years? Maybe I could substitute a good wine instead. Greg 47/35/35
Times0606,0000,0000
Greg,
Me too I haven't been able to get off sinemet. Not every PWP seems to be able to
function on agonists alone. But that doesn't say you can't do nothing. One very easy
measure is to take in stead of sinCR (if you use that) a sin.gen as last med. of the day. That will make the That will make the whole process of coming down faster and also the time you suffer from
dystonia.
Much research is going on now about anti-glutamates as possible med. for Parkinson.
They are expected to be very efficient against all Leva-dopa-induced-dyskinesias and
dystonias, as are surgeries in the Globus Pallidus and in the Sub Thalamic Nucleus.
Besides I did read somewhere on the net that a low dose of the anti-psychotic
clozapine could help and also the beta-blocker propanolol. Amantadine might have effect,
because it is an anti-glutamate, though a very weak one This med has been used for a
long time because it was coincidently learned it had an effect on Parkinson, but one
didn't understand why. It seems to be that the right anti-glutamate , which could do
the trick, has yet to be developed.
So the problem of "wearing off" dystonic dyskinesia has not yet been solved. Not
only there is not yet a therapy (except surgery), but for me there is yet one
puzzling question about it. I had the impression that "wearing off" dystonic dyskinesia
popped up when there was a shift in dopamine level. But other people pointed out it was
a definite range of the dopamine level,one goes through when there is a shift that
triggers the symptoms. I have for both theories empirical evidence, but they can't be
both true.
Ida
Kind regards / Vriendelijke groeten
Ida Kamphuis
