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I hope this works for you. Other people have had good results. My mama had a bad reaction to it. She had two pallidotomies this year and her only PD symptom that was not greatly alleviated was the rigidity/painful dystonia in her neck. When she was put on Comtan her neck almost went back to the way it was prior to the pallidotomies. It was scary for her and the rest of the family. Since getting off the Comtan her neck has gone back to "normal". We are now trying Requip. Teresa, Daughter of Mama (57/43/38) -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]]On Behalf Of Ralph Reichert Sent: Sunday, December 05, 1999 8:41 PM To: [log in to unmask] Subject: COMTRTAN (ENTACAPONE) seeking advice Edith is about to start COMTRAN (in addition to Atamet 25/100 5 times daily), for worstening tremor. Has anyone tried this drug? Anything to watch out for? Any helpful advice? Many thanks. Ralph.