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Greg. When I started 4 weeks ago, my Sinemet was 1-50/200 in the morning and 1-25/100 in the afternoon. My neuros recommended (effectively following the Requip package insert instructions) starting with .25mg 3x/day first week, .50mg 3x/day second week and increasing weekly thereafter by .25 mg 3x/day until I reach 1.5mg 3x/day at which time I go for an evaluation of the results. When I asked how and when to reduce the Sinemet, a got believe it or not, a nebulous answer, something like "when you think you're ready." I managed to wait two weeks and as I began the third week with .75 mg Requip 3x/day, I cut my morning Sinemet to 25/100 or in other words, cut my total dose of Sinemet by 1/3. I am now in my fourth week and taking 1.0 mg 3x/day and my tremors are slightly worse than before I cut the Sinemet but the stiffness in my writing hand is OK. I understand it could take longer yet for me to really have an effect from Requip. I don't plan to cut the Sinemet again at least until my next evaluation, even if the tremor control improves to my pre Requip days. For all I know, the experiment may not work but I wanted to try. I've had no adverse side effects from the Requip. Paul H. Lauer