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james, as far as i know, sinemet 25/100 won't build up in the system. On me, it lasts about 4 hours, and then is gone from the system. If the tremours are going to be controlled, they should be gone about an hour after you take the sinemet, that should be when it is at it's peak stage. good luck tex ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com