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Nancy, I have been taking COMTAN for 66 months. I find that COMTAN does increase the effectiveness of a given dose of Sinemet. I have not had any serious undesired sideeffects. The pills are rather large and not as easy to swallow as I would like. Sinemet tastes better. I am going in for my final assessment visit in the SEESAW study [the name given the study of the safety and effectiveness of entacapone [generic name] / COMTAN [marketing name in USA] / COMTESS [marketing name in Europe]. It may be useful for some people. I think I could have gotten the same results if I merely increased my Sinemet dosage slightly. I understand the cost is about $1.25 per tablet which would translate to about $5.00 per day. Give it a try and see what it does for you. ' Will Johnnston A.P.D.A. DelMarVA Chapter Pres. 4049 Oakland School Road Salisbury MD 21804 USA 410-543-0110 ---------- From: Jennifer Siegel <[log in to unmask]> To: [log in to unmask] Subject: Comtan Date: Friday, December 10, 1999 8:14 AM Some of you have probably discussed this before, but I am new to the group. Today my neurologist prescribed Comtan for me to take with my sinemet. I haven't seen the package insert yet, but would be interested in knowing what your experience and knowledge is about Comtan. Thank you, Nancy Spires