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Hi Nancy, You have it right. It can occur with neuroleptic malignant syndrome- (see archives) although I can't figure out why someone taking Comtan should get rhabdomyolysis since it occurs primarily in patients taking neuroleptics and sometimes in people who are rapidly withdrawn from Parkinson's meds, I guess it is possible that if Sinemet doses are not reduced then patients might get peak dose dystonia which might cause the rhabdomyolysis- or from another mechanism which I am unaware of. The rhabdomyolysis can cause injury to the kidneys. Where did you see the report? Charlie ----- Original Message ----- From: First & Last-Name <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, December 14, 1999 3:23 PM Subject: (no subject) > DOES ANYONE KNOW WHAT RHABDOMYOLYSIS IS? APPARENTLY THERE WERE SEVERE CASES > WITH COMTAN. I THINK LYSIS MEANS BREAKDOWN AND RHABDOMYO IS SKELETAL MUSCLES. > NANCY SPIRES