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>DOES ANYONE KNOW WHAT RHABDOMYOLYSIS IS? APPARENTLY THERE WERE SEVERE CASES >WITH COMTAN. I THINK LYSIS MEANS BREAKDOWN AND RHABDOMYO IS SKELETAL MUSCLES. >NANCY SPIRES You are correct. It is a severe breakdown of muscle tissue causing extreme toxicity which can lead to kidney failure. Muscle pain is the symptom, and is frequently ignored until the condition becomes critical. Because PD folks have muscle pain on a regular basis it is important that any usual pain be reported to the doctor immediately if Comtan is being taken. Incidentally, Rhabdomyolysis is also a side effect of cholesterol reducing drugs such as Lipitor. ------ Mary Ann (CG Jamie 60/40)