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Kathrynne: Thank you for the reply. As you might remember, I have been somewhat manic about insuring that I understood the relationship between Sinemet and protein because I'm tackling this stupid disease on all fronts with as much knowledge as I can muster. I wonder why, however, the instruction is to take Requip before eating. Is there some other process which affects the efficacy of the drug if you take it with meals or after eating. I will also reveal that I have a secret agenda in my attempt to wean off Sinemet. I WILL BE ABLE TO EAT SUSHI FOR LUNCH AGAIN! Regards, Paul H. Lauer