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First & Last-Name wrote: > > DOES ANYONE KNOW WHAT RHABDOMYOLYSIS IS? APPARENTLY THERE WERE SEVERE CASES > WITH COMTAN. I THINK LYSIS MEANS BREAKDOWN AND RHABDOMYO IS SKELETAL MUSCLES. > NANCY SPIRES Your guess at definition is right. And rhabdomyolysis is mentioned in the Comtan Package Insert, but no more than what you said above. If I had to guess, I should suspect that r.. results from prolonged over- stimulation, either by the rigidity symptomatic of PD, or by dyskinesia due to an excess of levodopa, which in turn might be due to the enhancement by Comtan. But the general tone of any PI mention of r.. suggests that the experts don't have a clue either. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013