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Hi Paul, > Kathrynne: Thank you for the reply. As you might remember, I have been > somewhat manic about insuring that I understood the relationship between > Sinemet and protein because I'm tackling this stupid disease on all fronts > with as much knowledge as I can muster. Boy, that's not manic in MY book, that's intelligence and a proactive attitude! > I wonder why, however, the > instruction is to take Requip before eating. Is there some other process > which affects the efficacy of the drug if you take it with meals or after > eating. According to the Clinical Pharmacology program, taking Requip WITH meals can decrease the likelihood of nausea; however, " Following oral administration, ropinirole is rapidly absorbed with peak plasma concentrations occurring in approximately 1—2 hours. Ropinirole oral bioavailability is 55%; food does not affect the extent of absorption, however, its Tmax is increased by 2.5 hours when the drug is taken with a meal." I don't know the meaning of Tmax -- any pharmacists around who can interpret that? > I will also reveal that I have a secret agenda in my attempt to wean > off Sinemet. I WILL BE ABLE TO EAT SUSHI FOR LUNCH AGAIN! Now that is a very good reason!! Best regards, Kathrynne -- Kathrynne Holden, MS, RD Medical nutrition therapy for Parkinson's disease Author: "Eat well, stay well with Parkinson's disease" "Parkinson's disease: assessing and managing unique nutrition needs;" "Risk for malnutrition and bone fracture in Parkinson'sdisease," J Nutr Elderly. V18:3;1999. http://www.nutritionucanlivewith.com/