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Dear Paul and Sir James: While the idea of titrating away from Sinemet sounds promising, the reality is that for some of us (myself included), the available agonists and their side-effects are intolerable. For ME, ReQuip was the worst of the lot. I would also add that while Sinemet has been around forever and its side-effects well documented, the long-term side-effects of the newer drugs will only emerge over time and trial. Carole --- Paul Lauer <[log in to unmask]> wrote: > Sir James: > My words can't be construed as advice because I am not a > medical professional > and can't lay claim to a wealth of experience because I > am only coming to the > end of my first year with the disease. However, (there > always seems to be > one), from everything I've read on this list and > elsewhere, the better bet is > to to titrate away from Sinemet rather than toward it, so > long as you can do > so without terribly affecting your quality of life. The > idea being that for > most (and apparently not for all) , the Sinemet too will > get you over time so > the longer the delay the longer it takes to get you. In > the belief in this > knowledge (which has been confirmed by both - count 'em - > my Neuros) I am > going in the other direction, increasing Requip and > decreasing Sinemet. > > Regards, > > Paul H. Lauer > __________________________________________________ Do You Yahoo!? Thousands of Stores. Millions of Products. All in one place. Yahoo! Shopping: http://shopping.yahoo.com