Mario - my neurologist, after changing the amount and timing two or three times, most recently recommended taking the sinemet with the permax (another agonist).  I also take mirapex (before bed) and selegeline (in the am). I don't believe that there is any bad interraction between selegeline and sinemet.  Some say one should be careful about taking selegeline and zoloft together, but my neuro says it is ok if the doeses of both are small.

Nancy S. deGrazia (62/6)