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Ivan M Suzman wrote: > I definitely continue to do much better on > Tolcapone (Tasmar) with Sinemet plus Selegeline > Hydrochloride, than with no Tolcapone. That may be well and good, but nonetheless, Tolcapone HAS demonstrated a capacity for irreversible fulminating hepatitis for some. There is no indication as yet as to what may predispose an individual to repond negatively to that drug. Our neuro has strongly discouraged the use of Tasmar for Barbara because she's had biliary and other hepatic problems in the past. Also, she could not afford the weight loss of blood every forthnight. Be well my friends, Michel