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Nancy S. Shlaes wrote: > Mario - my neurologist, after changing the amount and timing two or > three times, most recently recommended taking the sinemet with the > permax (another agonist). We were told to take Sinemet at least half hour before or after a meal because it works better when there is no competition from the food (amino acids from it, actually) to reach the brain sites. The Permax should be taken with meals to minimize gastric distress. Michel