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Dear Maryse: The troubling aspect of that is the fact that the author of that statement is an MD, and yet I still think he could be wrong. I have read on this list that orange juice as a provider of Vit. C is beneficial in maintaining stabilility and solubility of Sinemet, and even accelerates the rate of absorption of the drug. Grapefruit juice, however, did not. I have not personally verified the veracity of those statements. Do we need a pharmacist and/or a nutritionist expert in the subject? Michel Maryse Schild wrote: > On the french list someone (a GP) says one should not take orange juice > at the same time as Sinemet. he says it oxydizes the contents of the > medicament and destroys the active principle. I know that some people > dilute Sinemet in orange juice. What should one believe?