OTHER EVENTS REPORTED WITH DOPAMINERGIC THERAPY: the events listed below are rare events known to be associated with the use of drugs that increase dopaminergic activity, although they are most often associated with the use of direct dopamine agonists. RHABDOMYOLISIS: Cases of severe rhabdo have been reported with comtan use. the complicated nature of these cases makes it impossible to determine what role if any Comtan played in their pathogenesis. Severe prolonged motor activity including dyskinesia may account for rhabdo. one case, however, included fever and alteration of consciousness. it is therefore possible that the rhabdo may be a result of the syndrome described in hyperpyrexia and confusion (see precautions. other events reported wiht dopaminergic thearpy). j here it is, charlie, nancy s