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I take sinemet 100/25 at 2 1/2 hour intervals ,4 times per day. My startup time is 1 1/2 hours and each tablet works for about 2 1/2 hrs. I have found by self medicating that I can keep myself "ON" for 8- 10 hrs. At bedtime I take 2 tryptinol and I sleep like a box of bricks for 6 hours. I got PD at 32 now 57 and still using sinemet. Too much causes dyskinesia ( uncontrolled movement) and too little causes stiffness. You need to play with the meds to find your correct dose ----- Original Message ----- From: First & Last-Name <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, December 29, 1999 03:07 Subject: uptime average? > i take sinemet 25/100 five x/day with 200 mg comtan at the same time. > In general, for each four hour period (not counting 3a.m.) i get one and 1/2 > hr uptime (if i get up time). does this seem typical? > 11 pm med takes me to 3am when i can't sleep so wander around (shakily and > unbalanced) have some cereal while waiting for 7am dose due. i waste it by > sleeping until the 11am dose which usually works at noon-1:30; i wait til 3 > to take next dose, then wait an hr for it to work which it might or might > not. squeeze in supper 5:30. by six i need to sit in front of tv til 7 pm > pill which probably will give me 8-9:30. and over and over. with only 1 1/2 > hr it is tough to get one errand accomplished out of the house safely. > thanx > nancy spires > 59,55,50 > i forgot to say i take senokot because you know why. >