Hi Brian and all others...
Here is the web site for the clinical study...
http://clinicalstudies.info.nih.gov/detail/A_99-N-0104.html
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On 17 Feb 00 at 13:56, Brian Collins wrote:

> I am sorry to be the bearer of bad news, but the excitement at the news
> of imminent release of Dopamine patches is a little premature. The last
> time that I checked up on this subject the outcome was as follows:
>
> 1/ Dopamine patches would not work, because the Dopamine would be
> attacked and destroyed before it could travel from the patch to the
> brain.
>
> 2/ A levodopa patch would take care of the destruction while the chemical
> was in transit, but there is another factor which over-rides points 1
> and 2. That is:
>
> 3/ Levodopa and Dopamine are such large molecules, and we need it in such
> large quantities, that I doubt if you could could get the flow rate
> required even if you used a full body patch!! (What an apalling thought)
>
> 4/ I think you will find, it you scan the press releases which have been
> issued from time to time the magic word 'agonist' lurking quietly in
> the release.
>
> I can't help wondering what is the point of a Dopamine Agonist patch,
> when the dopamine agonist tablets have such a long half-life that in
> the case of Cabergoline for instance you only take one per day anyway!!
> Regards
>
> --
> Brian Collins  <[log in to unmask]>  (60/39/34)
>


all the best ............. murray
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