Dr.Romero, Since you are an M.D. maybe you could give me an answer. The
Neuro I have been going to gave me MYSOLINE 50mgs and I had to work my way
up to 1 in the a.m. and 2in the p.m.What is this used for and why would my
eyes feel swollen and sore around the eye lids? I have an appt. in Iowa City
, Iowa on the 6th of April at a movement Disorder clinic. I still have the
hand,jaw,tremors. Shirley
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----- Original Message -----
From: Jorge A. Romero, M.D. <[log in to unmask]>
To: <[log in to unmask]>
Sent: Tuesday, March 07, 2000 10:13 PM
Subject: Re: amitriptyline


> Amitriptyline is not contraindicated in Parkinson's Disease.
>
> Indeed, it can be beneficial in many ways:
>
> 1) it has anticholinergic activity which causes the side effect of dry
> mouth.  However this same anticholinergic activity may contribute to
control
> of tremor and bradykinesia.  Remember the first antiparkinsonian drugs
were
> anticholinergic drugs (benztropine and trihexiphenidyl - Cogentin and
> Artane, for example)
> 2) it has mild pro-dopaminergic activity (it is a catecholamine reuptake
> inhibitor) and thus could also by that mechanism exert a very mild
> antiparkinsonian effect.
> 3) it is a useful antidepressant - and 30 to 50% of PWPs are likely to
have
> significant symptoms of depression.
> 4) it helps sleep - and many PWP have trouble sleeping.
>
> In selected PWPs, it can be a very useful drug.
>
> Jorge Romero, MD
>
>
> ----- Original Message -----
> From: "Paul Lauer" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Tuesday, March 07, 2000 5:44 PM
> Subject: amitriptyline
>
>
> > I have had a stiff neck now going on a year. Neither my neuro, my
> orthopedist
> > and now a physiatrist(sp?) think it is PD related and I think I that it
is
> > most likely arthritis. I won't bore you with the various things which
have
> > been attempted since that is not my current subject. Add to the neck
> > problems, problems sleeping which are probably in some way PD related.
As
> a
> > result of both problems, my physiatrist is prescribing amitriptyline, 10
> mg,
> > which he says is a mild dose and should work both as a sleep aid and a
> > painkiller. He further says that in larger doses it is an
antidepressant,
> > which I don't need.
> >
> > I found the drug in Kathryn Holden's drug database but it doesn't
mention
> one
> > way or the other whether it is contraindicated for PD or not.
Experiences
> > anybody?
> >
> > Paul H. Lauer
> >