Diane,
You should avoid taking anti-psychotic, Reglan, Compazine (both anti-vomiting
drugs), and Benadryl unless prescribed by your neurologist. All these drugs may
exacerbate the symptoms. Demerol is no problem unless you are taking Eldepryl
(selegiline, deprenyl).

DIANE/GREG NICOLAOU wrote:

> Dave,
>
> Thanks for your reply about the Sinemet differences.  We are very lucky to
> have knowlegable professional people such as yourself on here.
>
> Dr.took me off the regular sinemet and switched me to the CR because the
> other was wearing off between doses (I've only been on the sinemet for two
> weeks)  and i've only taken the CR for two days now but it seems to be
> working ok.  I just wish i didn't have the nightmares all night.  Is that
> from the drug or P.D. or both?
>
> Also I have another question for you - I hear and read that there are drugs
> we should definately NOT take with PD while on sinemet can you tell me what
> they are (I'Ve heard Demerol is one).  I was on Covera HS (Verapimil) 240 mg
> largest dose-for hypertension went on sinemet started feeling light-headed
> and dizzy at times, checked my BP  (I work for a large cardiology group) and
> it was very low-then I read in PDR hypertensive meds should be adjusted
> BEFORE starting Sinemet so i called my family doc who took me off the Covera
> completely and my BP has remained just fine since.  Must be the neurologist
> overlooked that.  I am a cardiac ultrasound technician and can tell you lots
> about the heart but very little about the brain although i"m learning fast
> and many thanks to all of you for your help.             Diane
>  ( Original Message -----
> From: dpurdy <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Tuesday, February 27, 2001 9:52 AM
> Subject: Re: ?Too much Sinemet
>
> > Diane,
> > They both have the same total amount of each drug. However, the 25-100
> plain one
> > is released all at one time and wears off relatively quickly...probably
> gone
> > within at least 3 hours. On the other hand, the 25/100 CR has a smaller
> portion
> > of it released in the beginning and the rest gradually broken down over
> perhaps
> > 6 hours or less. Why did they change it? Were you needing it  soon after
> the
> > dose was taken? Was it not lasting very long? Personally, I can't take the
> CR. I
> > get dyskinetic and it lasts for a long time. I take permax and Sinemet
> > together...1/2 of each of them every 1 1/2 hours. That dosage has been
> ideal for
> > me. You will just have to try the CR and see how it does. Give a fair
> chance to
> > derive full benefits then make you decision as to the best of the two. You
> may
> > have head that Sinemet doesn't work after 8 yrs or so. Well, I've been on
> it
> > since 1984 (18 years) and it is still going fine. Good luck...mayyou have
> some
> > great days ahead.
> > Dave
> >
> > DIANE/GREG NICOLAOU wrote:
> >
> > > Dave- how is the Sinemet 25/100 and sinemet 25/100 CR different?  I know
> the
> > > latter stays in your system longer but how does it work and why would
> they
> > > use the Cr instead?
> > >
> > > I was switched today from sinemet 25/100 to the 25/100 CR  do they react
> or
> > > should i expect anything different?    Thanks                     Diane
> > > ----- Original Message -----
> > > From: dpurdy <[log in to unmask]>
> > > To: <[log in to unmask]>
> > > Sent: Tuesday, February 27, 2001 6:19 AM
> > > Subject: Re: ?Too much Sinemet
> > >
> > > > Mary,
> > > > The 10/100 has the same amt of levodopa. The carbidopa is less. The
> > > carbidopa is
> > > > being used to help the levodopa from being destroyed by enzymes and
> also
> > > to help
> > > > prevent nausea. It is felt that about 75mg per day is recommended.
> Excess
> > > > levodopa would probably result in dyskinesia (abnormal body movements
> such
> > > as
> > > > twisting etc.) You might want to discuss with the doctor that you want
> to
> > > > experiment with the  dosage a little. Perhaps splitting your levodopa
> in
> > > half and
> > > > taking it a little closer together might be a wise suggestion. Please
> let
> > > me know
> > > > your thoughts.
> > > >
> > > > Dave Purdy, retired R.Ph. & Parkinsonian
> > > >
> > > > Mary Legan wrote:
> > > >
> > > > > Please would you answer fast?  What are the signs & symptoms of too
> much
> > > > > Sinemet?  I've got to get my neuro to put me back to 10/100.  She
> has
> > > now put
> > > > > me on 25/100.  With new psychiatric meds, too, I need someone to
> help me
> > > > > Identify the signs & symptoms of too much sinemet so I can at least
> get
> > > her
> > > > > to go back to what I know was better for me.  She has many
> gatekeepers,
> > > & I
> > > > > will just be told to stay on what she said.  The thing is, because I
> had
> > > so
> > > > > many left,  I stayed on it way past when she knew about it.  I just
> > > started
> > > > > the 25/100 about 3 weeks ago, and am so uncomfortable.  Please tell
> me
> > > the
> > > > > signs & symptoms so I can articulate quickly what is happening.
> Would
> > > you
> > > > > send this quickly, if possible?
> > > > >
> > > > > MDawn30475805