Hi David--

David Meigs wrote:
>
> Ray,
>
> Do you ever monitor the PD list (PIENO)?  There were a few who had been a
> part of the fetal implant studies.  One that I remember for sure is Dr.
> Charles Meyer (psychiatrist)  Charlie had some bad dyskensias because of it.

I try to pay attention,
but didn't realize Dr. Charles Meyer had a transplant.
There is another person, a woman, wrote articulate reply to New York Times article,
thought I had squirreled it away,but can't find it now  --

> I remember another couple who had the "placebo" surgery.  I believe they
> declined having the implants later when they were given the chance because
> of the unpredictable outcomes.
>
> Another person on the PD list is Jim Finn.  He has done extremely well with
> the "Pig cell" transplant he had done a couple years ago.  His results have
> been phenomenal.

Yep, he's famous.

> Besides the age factor with the fetal cell transplants, I think the biggest
> factor was the amount & area of placement of the fetal cells.

Is this a new batch of implants? doubt it.
or, is this reworking of the statistics from the first time around?


> Take care,
>
> David Meigs
> [log in to unmask]
> Meigs Family Webpage:
> http://home.earthlink.net/~davidmeigs/index.html
> ----- Original Message -----
> From: "Raymond Strand" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Saturday, August 25, 2001 10:43 AM
> Subject: PMID: transplantation -- Freed still at it
>
> Hello list:
>
>  Stem cells have been at the forefront, but,
>  here is another example alternative cell transplant experimentation.
>
>  You will recall that the 3 year follow up study  of fetal implants
>  by Freed indicated differences between age groups in how well
>  the implant survived.  This study addresses that.
>  Freed is one of the authors.
>
>  I am curious about the details of "embryonic dopamine cell implantation".
>  Not stem cells, but, embryonic.
>
> Ray
>
>  .......................................................
> Ann Neurol 2001 Aug;50(2):181-7
>
> Blinded positron emission tomography study of dopamine cell implantation for
> Parkinson's disease.
>
> Nakamura T, Dhawan V, Chaly T, Fukuda M, Ma Y, Breeze R, Greene P, Fahn S,
> Freed
> C, Eidelberg D.
>
> Functional Brain Imaging Laboratory, North Shore-Long Island Jewish Research
> Institute, Manhasset, NY 11030, USA.
>
> We assessed nigrostriatal dopaminergic function in Parkinson's disease (PD)
> patients undergoing a double-blind, placebo-controlled surgical trial of
> embryonic dopamine cell implantation. Forty PD patients underwent positron
> emission tomography (PET) imaging with [18F]fluorodopa (FDOPA) prior to
> randomization to transplantation or placebo surgery. The 39 surviving
> patients
> were rescanned one year following surgery. Images were quantified by
> investigators blinded to treatment status and clinical outcome. Following
> unblinding, we determined the effects of treatment status and age on the
> interval changes in FDOPA/PET signal. Blinded observers detected a
> significant
> increase in FDOPA uptake in the putamen of the group receiving implants
> compared
> to the placebo surgery patients (40.3%). Increases in putamen FDOPA uptake
> were
> similar in both younger (age < or = 60 years) and older (age > 60 years)
> transplant recipients. Significant decrements in putamen uptake were
> evident in
> younger placebo-operated patients (-6.5%) but not in their older
> counterparts.
> Correlations between the PET changes and clinical outcome were significant
> only
> in the younger patient subgroup (r = 0.58). The findings suggest that
> patient
> age does not influence graft viability or development in the first
> postoperative
> year. However, host age may influence the time course of the downstream
> functional changes that are needed for clinical benefit to occur.
>
> PMID: 11506400 [PubMed - in process]
>
>  .......................................................
>


                                 Ray Strand
                             Prairie Sky Design
 -----------------(   on  the Edge of the Prairie Abyss  )---------------
                          when  the  sky  is  clear
                            the ground is visible

                          49/dx PD 47/40? onset

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