www.ncbi.nlm.gov

----- Original Message -----
From: "lucol" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Saturday, October 13, 2001 5:35 PM
Subject: Re: Has anyone tried SAM-e?


> Nilo,
>    There are several articles relating SAM-e to parkinson's at
> www.ncbi.nlm.nih    Thanks for raising the question.  I bought some today
at
> Walgreen's and plan to check it out on my own body.  Everything I read
about
> it is favorable.  Peace
> Carl
>
>
> ----- Original Message -----
> From: "NILO SARMIENTO" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Thursday, October 04, 2001 7:56 PM
> Subject: Has anyone tried SAM-e?
>
>
> > last week, i saw my neuro, and asked him about SAM-e; he said he had
heard
> > a lot of good things about it. I asked him if it would be OK for me to
> take
> > it.  He said, "OK, and let me know what you think of it."
> >
> > I am currently on sinemet 25/100, 3 times before a meal.  Just lately, a
> > fellow staff member who is very much into the Vitamin B family asked me
if
> > I was taking Vitamin B...I said, No.  I got curious, and did some
reading,
> > and found that B6 and B12 was good for the nervous system [excerpt
> > below]...and I proceeded to click on the link SAM-e.
> >
> > To make a long story short, when I receive my shipment of SAM-e 400mg
> > tomorrow or early next week, I going to include that as part of my
> regimen,
> > along with the Vitamin B6 and B12.
> >
> > if any of you has tried this, i'd like to know from your own personal
> > experience what the results have been.
> >
> > What Will B Complex Do For Me?
> > You probably didn't know that the most common nutritional deficiency in
> the
> > world is folic acid deficiency, which is characterized by low mood, and
> can
> > lead to neural tube defects in the developing, unborn child. Deficiency
in
> > either vitamins B-12 or B-6 can also bring about low mood, and often
mask
> > folic acid deficiency (which is why it is so important to take a
> supplement
> > that is a complete B-complex). In fact, folate supplementation, which in
> > large doses requires a doctor's prescription, is a long standing
treatment
> > in some cases of depression. B vitamins are not stored well in the body
> and
> > are depleted rapidly in dieters, and caffeine and alcohol users. The
> > B-complex is used throughout the body in methylation reactions and is
> > particularly effective against low mood, moodiness, muscular weakness
and
> > fatigue when combined with s-adenosyl methionine (see our SAM-e page for
> > more on methylation reactions and SAM-e).
> >
> >
> >
> > What Is S-Adenosyl Methionine / SAM-e?
> > S-Adenosyl Methionine (SAM or SAM-e; pronounced "sammy") is an amino
acid.
> > SAM-e was discovered in 1952 in Italy, where it is manufactured. Until
> > recently, it was exceedingly expensive to produce, and therefore
> > unavailable to the public, although it is fairly well studied. It is
> > manufactured in the brain from another amino acid, methionine. SAM-e is
> the
> > most active methyl-donor in your body, meaning it donates methyl groups
to
> > other chemical compounds in your body including neurotransmitters,
> changing
> > them into other compounds. SAM-e is then "recycled" through an ongoing
> > re-methylation process - more on this below.
> > SAM-e Improves Mood Fast!
> > The brain of a healthy person manufactures all the S-Adenosyl Methionine
> it
> > needs from methionine, but S-Adenosyl Methionine production is impaired
in
> > people who are depressed.1 Supplementation with SAM-e increases levels
of
> > serotonin, dopamine and phosphatides, and improves serotonin and
dopamine
> > receptor site binding.2 Interestingly, treatment with antidepressant
drugs
> > that results in improved mood (as determined by a 50% improvement in the
> > Hamilton Depression Inventory) usually also results in increased levels
of
> > SAM-e, regardless of the drug used.3
> >
> > Perhaps the most striking aspect of supplementation with SAM-e, is its
> > rapid onset of action. SAM-e has fewer side effects and has a more rapid
> > onset of action than tricyclics.1
> >
> >
> > 1 Murray, MT, Natural Alternatives to Prozac. Quill. New York.
> p174-5,1996.
> > 2 Baldessarini, RJ, Neuropharmacology of S-Adenosyl Methionine. Am J
Med.
> > 83:95-103, 1983.
> >
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