Hi! Vello:
    Thank you for your email on the biophysical hypothesis on the origin of
PD, ET and epilepsy.  Since I am not a biophysicist, most of the info in
this email are above me.  However, I have a couple of questions for you.

    1. You invoke a prion hypothesis in the beginning.  Aren't they
infective? Do you mean to say PD is infective?

    2.  The biophysical changes in the parameers that you have
elaborated -Are they the cause or the results of the disease?

    3. If so, what can one do to cure the disease, at least hypothetically?

    4. I remember reading about electromagnetic treatment for PD some time
ago.  Whatever happened to those studies and  why it is not popular any
more?

    Thanks.
    Raj
    [log in to unmask]
***************
----- Original Message -----
From: "Vello Reeben" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Thursday, June 20, 2002 6:32 AM
Subject: on a causal theory of PD


>       Hello Jorge, Kathrynne, Janet, Mary, Murray, Jan, Nilo, Carol, Bob,
> Raj, Ivan, Katie, Deborah, Emily/Julian, hello list,
>
>         I have been a silent subscriber of your list for a half of a year.
I
> am not a PWP, I have been a researcher of the Biophysics lab of Tartu
> University, Estonia, now retired. We have had here, in Estonia, regular
> spring schools on theoretical biology already for 28 years now. I have
been
> active in all of them, including the 1999 school on memory theory,
abstract
> of which (Vello & Mati Reeben, pp.42-49, in Estonian) consists a scetch of
a
> new BIOPHYSICAL theory of the genesis of parkinsonism, essential tremor
and
> absence epilepsy ( Mati - my son, molecular neurobiologist in Kuopio
> University, co-ordinator of an Eurogrant, EC FP5  QLG3-CT-2000-01405
> "Cystatin B in epilepsy", http://www.uku.fi/cystatin/)
>
>       We are convinced that today it is the time to take BIOPHYSICAL
> theories  more seriously as
>     1) the majority of neurodegenerative diseases, including PD, do
> demonstrate prion-like mechanisms resulting in accumulation of
> biophysically WRONGLY-FOLDED proteins which aggregate in dense-packed
> lesions (Lewy bodies,..) not obeying for normal decomposition processes,
>     2) the 2001 year Nobel prize work in physics (on coherent atomic
lasers)
> has given us direct experimental evidence that matter and waves/fields are
> very tightly interconnected indeed,
>     3) there are reports about mysterious clusters of young-onset PD
> (the case described by M.J.Fox in Canadian television staff, the case
> among Pittsburg University physicist's),
>     4) the chaperonin protein which helps to repair conformations,
probably
> through biophysical fields, works even in such far models like the
> Drosophila model and
>     5) sensitivity of PD patients to a low frequency (ca 0.75 Hz) movement
> stimulation.
>
>          We are convinced that important biomolecules are unique not only
> biochemically but also BIOPHYSICALLY, they fit not only into the metabolic
> pathways but also into the system of organismic and environmental rhythms.
>      According to our theory based on natural rhythms the main specific
> CAUSING mechanism of the mentioned neurodegenerative diseases (PD,
essenial
> tremor, absence epilepsy) lies in the existence of such powerful but
> informationally deviated natural RHYTHMS which happen to fall close to the
> normal informationally optimal physiologic rhythms (EEG waves).
>      Particularly, in the case of PD the alien rhythm threatens the EEG
> theta wave, less the delta (alpha/4) and alpha waves. That is why PD is
> characterized by a sharp-resonance resting tremor at EEG theta-wave
> frequency.
>      In theory the quantum jump from normal EEG theta wave to alien rhythm
> is extremely small in frequency scale (transition from 5.778 Hz to 5.761
Hz)
> but significant in quantum numbers (7*23*37 -> 2*2*3*3*3*5*11) which
> determine the (Sheldrake's morphic) resonance phenomena of bioatoms and
> small biomolecules.
>      For the EEG delta and alpha waves the quantum jump occurs through the
> prime divisors  23*37 -> 2*2*2*2*5*11.
>      As there are data that PD causes also involuntary changes in
breathing
> rhythm (PWP-s being afraid to crawl when swimming) and the PD main domain
> rhythm 6.25 s is not so far from the human main breathing rhythm 4.27 s
the
> corresponding quantum jump 7*23 -> 2*5*11 may also obtain an importance .
>
>     There exist a variety of evidence that the morphic resonance is caused
> by natural (atomic) rhythms and becomes evident for us through CHARGE (in
> DNA structures and amino acid residues of proteins) and MASS (in monomers
of
> non-protein polymers, in mediators, in metabolites, including risk
molecules
> of PD) NUMBERS.
>      The first quantum numbers (7*23*37, especially 23 in them) can be
> considered as DEFENCE FACTORS, the second quantum numbers
> (2*2*3*3*3*5*11, especially 11 in them) as RISK FACTORS favouring a
> quantum transition to  the PD-rhythm.
>      Under the attack are enzymes (alpha-synucleine,..) with Mn atoms
> (M=55=5*11) and dopaminergic, noradrenergic and serotonergic systems as
> dopamine has a mass M = 153; 154=2*7*11 noradrenaline has M = 169 = 13*13
> and serotonin has M = 176 = 2*2*2*2*11.
>      It appears that all the epidemiologically discovered risk factor
> molecules have MASS NUMBERS near to a 11-containing or 13-containing
> combination of the risk quantum numbers 2*2*3*3*3*5*11,  2*2*2*2*5*11,
> 2*5*11 and 2*2*2*3*3*13:
>
>   - MPTP:  M = 173;  176 = 2*2*2*2*11 - evoking agent,
>   - phenothiazine:  M = 198 = 2*3*3*11 - evoking agent,
>   - 6-hydroxydopamine: M = 169 = 13*13 -(noradrenergic) evoking agent,
>   - alpha-methylparatyrosine: M = 195 = 3*5*13 - (noradrenergic)
>     evoking agent,
>   - cysteinylglycine:  M = 176 = 2*2*2*2*11 - accumulating molecule,
>      recommended as a PD biomarker,
>   - methanol CH(3)OH:  M = 32; 33 = 3*11 - risk factor,
>   - CCl(4):  M = 153.8; 154 = 2*7*11 - risk factor,
>   - H(2)SO(4): M = 98; 99 = 3*3*11 - risk factor,
>   - (55)Mn: M = 55 = 5*11, causing factor, accumulating in substantia
>      nigra up to 18 times,
>   - (56)Fe-92%+(54)Fe-6%: thus 6% of Fe(2) has M = 110 = 2*5*11 -
>      element with significant accumulation,
>   - (197)Au:  M = 197.2; 198 = 2*3*3*11, strong accumulation (in
>      s.nigra),
>   - (198)Hg-10%:  M = 198; 198 = 2*3*3*11, accumulation,
>   - vitamin D rich nutrition: D(2): M = 396.6; 396 = 2*2*3*3*11,
>                               D(3): M = 384.6; 385 = 5*7*11.
>       Some of the drug-induced PD forms find also an explanation in this
> rhythm/resonance theory:
>   - reserpine: M = 608; 605 = 5*11*11,
>   - trifluoperazine: M = 479/483; 484 = 2*2*11*11,
>
>     This theory also makes it more easy to understand why the PWP-s
> start dislike potatoes (starch M = 162*n, 161=7*23), crave sugar
> (monosaccharide hydrate M = 198 = 2*3*3*11, disaccharides M = 342;
> 341=11*31) and avoid alchohol, beer (ethanol M = 46 = 2*23).
>
>         The present theory allows us to make predictions which can be
> tested:
>     1) as the epidemiologic studies from Germany, Japan, USSR and USA have
> ascertained that pesticides of fruit gardening is a risk factor for PD but
> have not yet cleared up which one of them is to be blamed, so our
> rhythm/resonance-based theory can point here to a probable candidate:
> malathion (carbophos): M = 330 = 2*3*5*11 as being rather near to
> 2*2*3*3*3*5*11,
>      2) the most probable (1:4:9:16:36:49:64:144:196)-frequencies where PD
> patients may reveal sensitivity to some kind stimulations are:
> 6.25 s, 1.56 s, 1.44 Hz, 2.56 Hz, 5.76 Hz, 7.84 Hz, 10.2 Hz, 23.0 Hz, 31.4
> Hz
>      3) the most probable frequencies of the noradrenergic form of PD are
> 7.44 s, 1.21 Hz, 4.84 Hz, 6.59 Hz, 10.9 Hz, 30.3 Hz.
>         The present theory has, of course, deeper roots, indicating that
> elements of a new biophysical paradigm are already knocking at the door of
> the 2000 millennium science. But, as usually in science, a new theory will
> not appear in ease, pioneers need a growth time and opponents an
> understandig that the existing theories (biochemical medicine) will really
> benefit from the ideas of younger brothers (biophysical paradigm).
>      So happend also in our case, our first 10 pages more general paper to
a
> Paris conference was not accepted in June 2000 (one referee accepting, two
> rejecting).
>
>      We write now this mail with an aim to be helpful in many ways:
>
>   - for PWP and medical science to strengthen the hope that the
>     existing symptomatic approach will soon grow to a more causal
>     theory,
>   - for curious outway-seeking PWP a new helping tool for independent
>     search of various possible remedies,
>   - for us a communication possibility helping to reach to a clear
>     presentation of our new ideas,
>   - for medical epidemiology, pharmacy and pesticide industry to get a
>     simple preliminary test to find out which chemicals might be
>     PD-causing.
>
>         Here are the data about the theoretical parameters N, period T or
> frequency 1/T, N/N(opt) and square root (N) of the physiological rhythms
and
> PD-causing rhythms found as unique parts T = T(0)/N of the galactic year
> where T(0) = 205133000 years:
>    - breathing rhythm:
>      N = 2*2*2*2*3*3*3*3*5*5*7*7*11*13*17*19*23*29*31,
>       period T = 4.27 s, N/N(opt) = 1.00, (this parameter shows a
>       deviation from the informational optimum, at 1.00 we have optimal
>       Ramanujan's highly composite numbers), square root(N) = n.xxxxx;
>      (this last parameter is an indicator of powerfulness of a rhythm).
>   - EEG theta rhythm:
>     N = 2*2*2*2*2*3*3*3*5*5*7*7*11*13*17*19*23*29*31*37,
>      5.78 Hz/1.028/n.9971,
>   - EEG alpha rhythm:
>     N = 2*2*2*2*2*3*3*3*3*5*5*7*11*13*17*19*23*29*31*37,
>      9.90 Hz/1.057/n.9797,
>   - PD domain rhythm (for which there exists a unique composite
>      extremely near-quadratic N = (n*n-1)-type number:
>     N = 2*2*2*2*2*3*3*3*3*5*5*5*7*11*11*13*17*19*23*29*31*37,
>      6.25 s/2.648/n.999999985,
>   - PD subrhythms: N(s2)=N*2*2, 1.56 s/2.39/n.999999970,
>                    N(s4)=N*4*4, 2.56 Hz/2.73/n.999999940,
>                    N(s6)=N*6*6, 5.76 Hz/3.69/n.999999911,
>                    N(s12)=N*12*12, 23.0 Hz/4.92//n.99999982.
>
>      Theoretically most suspicious are molecules with M = n*11 and
> M = n*11*11 having a molecular  weight close to risk factor quantum
numbers
> 2*2*3*3*3*5*11, 2*2*2*2*5*11 and 2*5*11, that is M = 55, 110, 121, 165,
176,
> 198, 220, 242, 330, 363, 484, 605.
>
>        The less pronounced PD form which attacks noradrenergic
> (noradrenaline - M = 169 = 13*13) processes and is usually localized in
> other regions of the brain (hypothalamus) has also highly specific
> theoretical explanation here:
>   - domain rhythm
>   N = 2*2*2*2*2*2*2*2*2*2*3*3*5*5*7*11*13*13*17*19*-*29*31,
>    7.44 s/4.45/n.999999983,
>   - the N*3*3 rhythm 1.21 Hz/3.88/n.999999949
>   - close to EEG theta wave rhythm N = N*6*6, 4.84 Hz/5.17/n.999999898
>   - close to EEG alpha wave rhythm N = N*9*9,
>     10.9 Hz/5.81/n.999999847,introducing a quantum jump
>     23*37 -> 2*2*2*3*3*13.
>
>        It seems that the 11-containing quantum numbers are important in
the
> genesis of sporadic PD and the 13-containing quantum number molecules may
> also play an ignition of the PD processes when introduced in big doses as
in
> animal models.
>
>      BTW, in this theory the subrhythms appear in the same quadratic
manner
> as the spectral series of the hydrogen atom in Balmer/Rydberg/Bohr quantum
> theory.
>
>       Do not hesitate asking questions, they will help you and us.
>
>        A remark:  C(13), O(18) and S(34) slightly raise the molecular
weight
> giving 0.3% - 4% M+1 or M+2 molecules), it seems that 3-valent N when in
> symmetrical position (like in MPTP) can weakly tie two more H.
>
> Vello Reeben
>
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