Dear RAYILYN, and PIEN friends,

  Have you tried taking Sinemet 30 minutes before eating?
It won't work as well if too much food , especiallly protein-
rich or fatty foods block it from being absorbed.

If you took Sinemet when you sit down to  eat, it
will work POORL Y and UNPREDICTABLY.
Both SInemet CR and Sinemet contain L-dopa,
or levo dyhydroxy phenylalanine.

   Phenylalanine is a long-chain
amino acid,  and a building block of
larger protein molecules.  Rayilyn,if YOUR DIET
is too high in protein, the semi-permeable blood-brain
barrier will not allow your brain to absorb the L-dopa in
either Sinemet or in Sinemet CR .

 Your diet, if it is a typical American diet, is protein-rich.
Noraml eating will supply the brain with so many amino acids
that the blood-brtain barrier's "gates" will be
closed by the time the L-dopa from the Sinemet
tries to get through.

Both Sinemets are designed to disperse  their L-dopa
 in the blood stream, which then heads for the brain, only
after their L-dopa achieves absorption in the INTESTINES.

I wish that the pharmaceutical companies
would make up a new L-dopa - containing
medicine, that is fast-acting, and absorbed UNIFORMLY
in the mouth, nose, throat or at least, stomach.

The waiiting time for Sinemet  is truly shameful.

Ivan  Suzman
Mailbag Editor,. PDF
53/39/35


way too long.

On Sun, 9 Mar 2003 17:09:44 EST Rayilyn Brown <[log in to unmask]>
writes:
> Hi, Sharon,,
>
> my tremors and dystonia were never helped by  PD meds' n fact after
> a year on
> Sinemet (I was "ON" for a couple of hours), my foot/toes dystonia
> got worse.
> so I don't take PD meds now - my 7th year.  Botox injections in my
> leg didn't
> help either.
>
> I have the awful stiffness now and use an electric wheelchaiir
> part-time -
> exercise in my exercise-therapy pool and am hoping to drag ny body
> back to
> treadmill again. A year ago I could do a mile on it.  I am just
> "OFF" all the
> time, but meds were woefully inadequate.  My first neuro told me PD
> meds were
> "tricky" - now I know what he meant.
>
> It seems  I am in a minority - most people on the List benefit
> greatly from
> the meds and yes, I have a F-DOPA PET scan from UCLA that confirms
> diagnosis
> of idiopathic PD by 5 neuros.
>
> Hope you have better luck than I have, but if you don't, you are not
> alone.
>
> Rayilyn - 60/67
>
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