Thank you, Chris :
No. my "end of dose " phenomenom is the onset of dyskinesia. I seem to
have both "peak dose" and "end of dose" dyskinesia. I have been taking
sinemet for almost 10 years and over that period have added eldepryl,
permax, mirapex and amantadine. I guess the reason I am taking so many
different things is that I am hypersensitive to levadopa. I take 1/4 of
a 25/100 every 90 minutes and if I take more the dyskinesia is just awful..

Anyone else with this kind of problem?

Nancy deG

Chris Lui wrote:

>Hi Nancy:
>
>My end of dose phenomenon refers to premature ending of the effectiveness of
>the medicine, a shortened drug effect experienced after 3 years of
>medication.  Have you got the similar problem?
>
>Chris Lui
>
>----- Original Message -----
>From: "Nancy S. deGrazia" <[log in to unmask]>
>To: <[log in to unmask]>
>Sent: Tuesday, September 16, 2003 6:57 PM
>Subject: Re: COMTAN
>
>
>
>
>>Chris Lui:- iis the "end of dose" phenomenon you referred to (A) a
>>premature ending of the effectiveness of the medecine or (b) dyskinesia
>>which manifests itself at the end of a dose?
>>
>>Your response will clarify my situation for which I would be very
>>
>>
>grateful.
>
>
>>Nancy S deGrazia
>>
>>
>>
>>Chris Lui wrote:
>>
>>
>>
>>>Hi ALL,
>>>
>>>Today my neuro starts putting me on COMTAN to addrerss the end of dose
>>>
>>>
>phenomenon.  Any one has got any advice or comment about the use of this
>drug?  Be it favourable or adverse,  your experience would certainly help!
>Thanks!
>
>
>>>Chris Lui
>>>
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