--- "Nancy S. deGrazia" <[log in to unmask]>
wrote:
> Thank you, Chris :
> No. my "end of dose " phenomenom is the onset of
> dyskinesia. I seem to
> have both "peak dose" and "end of dose" dyskinesia.
> I have been taking
> sinemet for almost 10 years and over that period
> have added eldepryl,
> permax, mirapex and amantadine. I guess the reason I
> am taking so many
> different things is that I am hypersensitive to
> levadopa. I take 1/4 of
> a 25/100 every 90 minutes and if I take more the
> dyskinesia is just awful..
>
> Anyone else with this kind of problem?
> I used to have diskinesias  that on a 1  to  10
scale mine were up to 13 or 14 . Then i had a
pallidototomy.   For the most part I have been free of
dyskinesia  since then (1995}
David Moreland
> Nancy deG
>
> Chris Lui wrote:
>
> >Hi Nancy:
> >
> >My end of dose phenomenon refers to premature
> ending of the effectiveness of
> >the medicine, a shortened drug effect experienced
> after 3 years of
> >medication.  Have you got the similar problem?
> >
> >Chris Lui
> >
> >----- Original Message -----
> >From: "Nancy S. deGrazia" <[log in to unmask]>
> >To: <[log in to unmask]>
> >Sent: Tuesday, September 16, 2003 6:57 PM
> >Subject: Re: COMTAN
> >
> >
> >
> >
> >>Chris Lui:- iis the "end of dose" phenomenon you
> referred to (A) a
> >>premature ending of the effectiveness of the
> medecine or (b) dyskinesia
> >>which manifests itself at the end of a dose?
> >>
> >>Your response will clarify my situation for which
> I would be very
> >>
> >>
> >grateful.
> >
> >
> >>Nancy S deGrazia
> >>
> >>
> >>
> >>Chris Lui wrote:
> >>
> >>
> >>
> >>>Hi ALL,
> >>>
> >>>Today my neuro starts putting me on COMTAN to
> addrerss the end of dose
> >>>
> >>>
> >phenomenon.  Any one has got any advice or comment
> about the use of this
> >drug?  Be it favourable or adverse,  your
> experience would certainly help!
> >Thanks!
> >
> >
> >>>Chris Lui
> >>>
>
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