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PARKINSN Home

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PARKINSN  December 2003, Week 2

PARKINSN December 2003, Week 2

Subject:

Re: Important article re: the medications we all take.

From:

Peggy Willocks <[log in to unmask]>

Reply-To:

Peggy Willocks <[log in to unmask]>

Date:

Wed, 10 Dec 2003 07:43:50 -0500

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (154 lines)

Thanks, Gail.

This article is not really surprising, nor is it "bad" news.  What Dr. Roses
is saying is that the past strategy of mass marketing drugs is going to
change for his company (GlasoSmithKline - GSK).  They want to focus more on
drugs that work in gene-specific cases.  That's GOOD news for Parkinson's!
We don't have the numbers like cancer, heart disease, etc., so this approach
can only help us.

I believe Dr. Roses is saying that GSK is trying to get away from
polypharmacy, where you take one drug then take two more due to side
effects.  He's a brave man to speak publicly about this fresh new approach.

I'm glad that someone is finally telling the world the truth - there is no
way one drug to be effective for everyone given our genetic make-up.  A
false assumption has been a marketing strategy for years.

Peggy

----- Original Message -----
From: "Gail Vass" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, December 08, 2003 1:34 PM
Subject: Important article re: the medications we all take.


> Folks ,
>
> This is a staggering admission and it has many ramifications
> for each one of us. Please read and give some consideration
> concerning your own situation .
>
> Gail
> ~~~~~~~~~~~~~~~~~~~~~
>
> "Glaxo chief: Our drugs do not work on most patients"
>
>    By Steve Connor, Science Editor, 08 December 2003
>
> http://news.independent.co.uk/world/science_medical/story.jsp?story=471139
>
> A senior executive with Britain's biggest drugs company
> has admitted that most prescription medicines do not work
> on most people who take them.
>
> Allen Roses, worldwide
> vice-president of genetics at GlaxoSmithKline (GSK), said fewer than
> half of the patients prescribed some of the most expensive drugs actually
> derived any benefit from them.
>
> It is an open secret within the drugs industry that most of its products
are
> ineffective in most patients but this is the first time that such a senior
drugs
>  boss has gone public. His comments come days after it emerged that the
> NHS drugs bill has soared by nearly 50 per cent in three years, rising by
> £2.3bn a year to an annual cost to the taxpayer of £7.2bn. GSK announced
> last week that it had 20 or more new drugs under development that could
> each earn the company up to $1bn (£600m) a year.
>
>  Dr Roses, an academic geneticist from Duke University in North Carolina,
> spoke at a recent scientific meeting in London where he cited figures on
> how well different classes of drugs work in real patients.
>
> Drugs for Alzheimer's disease work in fewer than one in three patients,
> whereas those for cancer are only effective in a quarter of patients.
Drugs
> for migraines, for osteoporosis, and arthritis work in about half the
patients,
> Dr Roses said. Most drugs work in fewer than one in two patients mainly
>  because the recipients carry genes that interfere in some way with the
> medicine, he said.
>
>  "The vast majority of drugs - more than 90 per cent - only work in 30 or
> 50 per cent of the people," Dr Roses said. "I wouldn't say that most drugs
> don't work. I would say that most drugs work in 30 to 50 per cent of
people.
> Drugs out there on the market work, but they don't work in everybody."
>
> Some industry analysts said Dr Roses's comments were reminiscent of
> the 1991 gaffe by Gerald Ratner, the jewellery boss, who famously said
> that his high street shops are successful because they sold "total crap".
> But others believe Dr Roses deserves credit for being honest about a
> little-publicised fact known to the drugs industry for many years.
>
> "Roses is a smart guy and what he is saying will surprise the public but
not
> his colleagues," said one industry scientist. "He is a pioneer of a new
culture
> within the drugs business based on using genes to test for who can benefit
>  from a particular drug."
>
> Dr Roses has a formidable reputation in the field of "pharmacogenomics"
> - the application of human genetics to drug development - and his comments
> can be seen as an attempt to make the industry realise that its future
rests on
> being able to target drugs to a smaller number of patients with specific
genes.
>
> The idea is to identify "responders" - people who benefit from the drug -
> with  a simple and cheap genetic test that can be used to eliminate those
> non-responders who might benefit from another drug.
>
> This goes against a marketing culture within the industry that has relied
on
> selling as many drugs as possible to the widest number of patients - a
culture
> that has made GSK one of the most profitable pharmaceuticals companies,
> but which has also meant that most of its drugs are at best useless, and
even
> possibly dangerous, for many patients.
>
> Dr Roses said doctors treating patients routinely applied the
trial-and-error
> approach which says that if one drug does not work there is always another
> one. "I think everybody has it in their experience that multiple drugs
have
> been used for their headache or multiple drugs have been used for their
> backache or whatever.
>
>  "It's in their experience, but they don't quite understand why. The
reason
> why is because they have different susceptibilities to the effect of that
drug
> and that's genetic," he said.
>
> "Neither those who pay for medical care nor patients want drugs to be
> prescribed that do not benefit the recipient. Pharmacogenetics has the
> promise of removing much of the uncertainty."
>
> Response rates :  Therapeutic area: drug efficacy rate in per cent
>
> Alzheimer's: 30 %
> Analgesics (Cox-2): 80 %
> Asthma: 60 %
> Cardiac Arrythmias: 60 %
> Depression (SSRI): 62 %
> Diabetes: 57 %
> Hepatits C (HCV): 47 %
> Incontinence: 40 %
> Migraine (acute): 52 %
> Migraine (prophylaxis) 50 %
> Oncology: 25 %
> Rheumatoid arthritis 50 %
> Schizophrenia: 60 %
>
> ----------------------------------------------------------------------
> To sign-off Parkinsn send a message to:
mailto:[log in to unmask]
> In the body of the message put: signoff parkinsn

----------------------------------------------------------------------
To sign-off Parkinsn send a message to: mailto:[log in to unmask]
In the body of the message put: signoff parkinsn

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January 2004, Week 4
January 2004, Week 3
January 2004, Week 2
January 2004, Week 1
December 2003, Week 5
December 2003, Week 4
December 2003, Week 3
December 2003, Week 2
December 2003, Week 1
November 2003, Week 5
November 2003, Week 4
November 2003, Week 3
November 2003, Week 2
November 2003, Week 1
October 2003, Week 5
October 2003, Week 4
October 2003, Week 3
October 2003, Week 2
October 2003, Week 1
September 2003, Week 5
September 2003, Week 4
September 2003, Week 3
September 2003, Week 2
September 2003, Week 1
August 2003, Week 5
August 2003, Week 4
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August 2003, Week 1
July 2003, Week 5
July 2003, Week 4
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July 2003, Week 1
June 2003, Week 5
June 2003, Week 4
June 2003, Week 3
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June 2003, Week 1
May 2003, Week 5
May 2003, Week 4
May 2003, Week 3
May 2003, Week 2
May 2003, Week 1
April 2003, Week 5
April 2003, Week 4
April 2003, Week 3
April 2003, Week 2
April 2003, Week 1
March 2003, Week 5
March 2003, Week 4
March 2003, Week 3
March 2003, Week 2
March 2003, Week 1
February 2003, Week 4
February 2003, Week 3
February 2003, Week 2
February 2003, Week 1
January 2003, Week 5
January 2003, Week 4
January 2003, Week 3
January 2003, Week 2
January 2003, Week 1
December 2002, Week 5
December 2002, Week 4
December 2002, Week 3
December 2002, Week 2
December 2002, Week 1
November 2002, Week 5
November 2002, Week 4
November 2002, Week 3
November 2002, Week 2
November 2002, Week 1
October 2002, Week 5
October 2002, Week 4
October 2002, Week 3
October 2002, Week 2
October 2002, Week 1
September 2002, Week 5
September 2002, Week 4
September 2002, Week 3
September 2002, Week 2
September 2002, Week 1
August 2002, Week 5
August 2002, Week 4
August 2002, Week 3
August 2002, Week 2
August 2002, Week 1
July 2002, Week 5
July 2002, Week 4
July 2002, Week 3
July 2002, Week 2
July 2002, Week 1
June 2002, Week 5
June 2002, Week 4
June 2002, Week 3
June 2002, Week 2
June 2002, Week 1
May 2002, Week 5
May 2002, Week 4
May 2002, Week 3
May 2002, Week 2
May 2002, Week 1
April 2002, Week 5
April 2002, Week 4
April 2002, Week 3
April 2002, Week 2
April 2002, Week 1
March 2002, Week 5
March 2002, Week 4
March 2002, Week 3
March 2002, Week 2
March 2002, Week 1
February 2002, Week 4
February 2002, Week 3
February 2002, Week 2
February 2002, Week 1
January 2002, Week 5
January 2002, Week 4
January 2002, Week 3
January 2002, Week 2
January 2002, Week 1
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December 2001, Week 4
December 2001, Week 3
December 2001, Week 2
December 2001, Week 1
November 2001, Week 5
November 2001, Week 4
November 2001, Week 3
November 2001, Week 2
November 2001, Week 1
October 2001, Week 5
October 2001, Week 4
October 2001, Week 3
October 2001, Week 2
October 2001, Week 1
September 2001, Week 5
September 2001, Week 4
September 2001, Week 3
September 2001, Week 2
September 2001, Week 1
August 2001, Week 5
August 2001, Week 4
August 2001, Week 3
August 2001, Week 2
August 2001, Week 1
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July 2001, Week 3
July 2001, Week 2
July 2001, Week 1
June 2001, Week 5
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June 2001, Week 3
June 2001, Week 2
June 2001, Week 1
May 2001, Week 5
May 2001, Week 4
May 2001, Week 3
May 2001, Week 2
May 2001, Week 1
April 2001, Week 5
April 2001, Week 4
April 2001, Week 3
April 2001, Week 2
April 2001, Week 1
March 2001, Week 5
March 2001, Week 4
March 2001, Week 3
March 2001, Week 2
March 2001, Week 1
February 2001, Week 4
February 2001, Week 3
February 2001, Week 2
February 2001, Week 1
January 2001, Week 5
January 2001, Week 4
January 2001, Week 3
January 2001, Week 2
January 2001, Week 1
December 2000, Week 5
December 2000, Week 4
December 2000, Week 3
December 2000, Week 2
December 2000, Week 1
November 2000, Week 5
November 2000, Week 4
November 2000, Week 3
November 2000, Week 2
November 2000, Week 1
October 2000, Week 5
October 2000, Week 4
October 2000, Week 3
October 2000, Week 2
October 2000, Week 1
September 2000, Week 5
September 2000, Week 4
September 2000, Week 3
September 2000, Week 2
September 2000, Week 1
August 2000, Week 5
August 2000, Week 4
August 2000, Week 3
August 2000, Week 2
August 2000, Week 1
July 2000, Week 5
July 2000, Week 4
July 2000, Week 3
July 2000, Week 2
July 2000, Week 1
June 2000, Week 5
June 2000, Week 4
June 2000, Week 3
June 2000, Week 2
June 2000, Week 1
May 2000, Week 5
May 2000, Week 4
May 2000, Week 3
May 2000, Week 2
May 2000, Week 1
April 2000, Week 5
April 2000, Week 4
April 2000, Week 3
April 2000, Week 2
April 2000, Week 1
March 2000, Week 5
March 2000, Week 4
March 2000, Week 3
March 2000, Week 2
March 2000, Week 1
February 2000, Week 5
February 2000, Week 4
February 2000, Week 3
February 2000, Week 2
February 2000, Week 1
January 2000, Week 5
January 2000, Week 4
January 2000, Week 3
January 2000, Week 2
January 2000, Week 1
December 1999, Week 5
December 1999, Week 4
December 1999, Week 3
December 1999, Week 2
December 1999, Week 1
November 1999, Week 5
November 1999, Week 4
November 1999, Week 3
November 1999, Week 2
November 1999, Week 1
October 1999, Week 5
October 1999, Week 4
October 1999, Week 3
October 1999, Week 2
October 1999, Week 1
September 1999, Week 5
September 1999, Week 4
September 1999, Week 3
September 1999, Week 2
September 1999, Week 1
August 1999, Week 5
August 1999, Week 4
August 1999, Week 3
August 1999, Week 2
August 1999, Week 1
July 1999, Week 5
July 1999, Week 4
July 1999, Week 3
July 1999, Week 2
July 1999, Week 1
June 1999, Week 5
June 1999, Week 4
June 1999, Week 3
June 1999, Week 2
June 1999, Week 1
May 1999, Week 5
May 1999, Week 4
May 1999, Week 3
May 1999, Week 2
May 1999, Week 1
April 1999, Week 5
April 1999, Week 4
April 1999, Week 3
April 1999, Week 2
April 1999, Week 1
March 1999, Week 5
March 1999, Week 4
March 1999, Week 3
March 1999, Week 2
March 1999, Week 1
February 1999, Week 4
February 1999, Week 3
February 1999, Week 2
February 1999, Week 1
January 1999, Week 5
January 1999, Week 4
January 1999, Week 3
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January 1999, Week 1
December 1998, Week 5
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November 1998, Week 3
November 1998, Week 2
November 1998, Week 1
October 1998, Week 5
October 1998, Week 4
October 1998, Week 3
October 1998, Week 2
October 1998, Week 1
September 1998, Week 5
September 1998, Week 4
September 1998, Week 3
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August 1998, Week 5
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August 1998, Week 1
July 1998, Week 5
July 1998, Week 4
July 1998, Week 3
July 1998, Week 2
July 1998, Week 1
June 1998, Week 5
June 1998, Week 4
June 1998, Week 3
June 1998, Week 2
June 1998, Week 1
May 1998, Week 5
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May 1998, Week 3
May 1998, Week 2
May 1998, Week 1
April 1998, Week 5
April 1998, Week 4
April 1998, Week 3
April 1998, Week 2
April 1998, Week 1
March 1998, Week 5
March 1998, Week 4
March 1998, Week 3
March 1998, Week 2
March 1998, Week 1
February 1998, Week 5
February 1998, Week 4
February 1998, Week 3
February 1998, Week 2
February 1998, Week 1
January 1998, Week 5
January 1998, Week 4
January 1998, Week 3
January 1998, Week 2
January 1998, Week 1
December 1997, Week 5
December 1997, Week 4
December 1997, Week 3
December 1997, Week 2
December 1997, Week 1
November 1997, Week 5
November 1997, Week 4
November 1997, Week 3
November 1997, Week 2
November 1997, Week 1
October 1997, Week 5
October 1997, Week 4
October 1997, Week 3
October 1997, Week 2
October 1997, Week 1
September 1997, Week 5
September 1997, Week 4
September 1997, Week 3
September 1997, Week 2
September 1997, Week 1
August 1997, Week 5
August 1997, Week 4
August 1997, Week 3
August 1997, Week 2
August 1997, Week 1
July 1997, Week 5
July 1997, Week 4
July 1997, Week 3
July 1997, Week 2
July 1997, Week 1
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June 1997, Week 4
June 1997, Week 3
June 1997, Week 2
June 1997, Week 1
May 1997, Week 5
May 1997, Week 4
May 1997, Week 3
May 1997, Week 2
May 1997, Week 1
April 1997, Week 5
April 1997, Week 4
April 1997, Week 3
April 1997, Week 2
April 1997, Week 1
March 1997, Week 5
March 1997, Week 4
March 1997, Week 3
March 1997, Week 2
March 1997, Week 1
February 1997, Week 5
February 1997, Week 4
February 1997, Week 3
February 1997, Week 2
February 1997, Week 1
January 1997, Week 5
January 1997, Week 4
January 1997, Week 3
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December 1996, Week 5
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December 1996, Week 3
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October 1996, Week 3
October 1996, Week 2
October 1996, Week 1
September 1996, Week 5
September 1996, Week 4
September 1996, Week 3
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April 1996, Week 3
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April 1996, Week 1
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March 1996, Week 3
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March 1996, Week 1
February 1996, Week 5
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February 1996, Week 3
February 1996, Week 2
February 1996, Week 1
January 1996, Week 5
January 1996, Week 4
January 1996, Week 3
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December 1995, Week 5
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July 1995, Week 2
July 1995, Week 1
June 1995, Week 5
June 1995, Week 4
June 1995, Week 3
June 1995, Week 2
June 1995, Week 1
May 1995, Week 5
May 1995, Week 4
May 1995, Week 3
May 1995, Week 2
May 1995, Week 1
April 1995, Week 5
April 1995, Week 4
April 1995, Week 3
April 1995, Week 2
April 1995, Week 1
March 1995, Week 5
March 1995, Week 4
March 1995, Week 3
March 1995, Week 2
March 1995, Week 1
February 1995, Week 4
February 1995, Week 3
February 1995, Week 2
February 1995, Week 1
January 1995, Week 5
January 1995, Week 4
January 1995, Week 3
January 1995, Week 2
January 1995, Week 1
December 1994, Week 5
December 1994, Week 4
December 1994, Week 3
December 1994, Week 2
December 1994, Week 1
November 1994, Week 5
November 1994, Week 4
November 1994, Week 3
November 1994, Week 2
November 1994, Week 1
October 1994, Week 5
October 1994, Week 4
October 1994, Week 3
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June 1994, Week 1
May 1994, Week 5
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May 1994, Week 3
May 1994, Week 2
May 1994, Week 1
April 1994, Week 5
April 1994, Week 4
April 1994, Week 3
April 1994, Week 2
April 1994, Week 1
March 1994, Week 5
March 1994, Week 4
March 1994, Week 3
March 1994, Week 2
March 1994, Week 1
February 1994, Week 4
February 1994, Week 3
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