From a subjective point of view mirapex exacerbates dyskenesia dramaticly.
I am midway thru a study on this issue at ohsu in portland.  Dyskinesia
disappeared almost completely w/o the mirapex but of course there are some
very positive benefits to mirapex also.  I can amubulate!  There is also a
much better chance of winning the lottery.  It will be interesting to see
the published report at the end of the study.
\Randy


Games to entertain your brain.
http://www.stargraphics.com

Star Graphics Corp
10943 S Forest Ridge Ln
Oregon City, OR 97045
----- Original Message -----
From: "mackenzie" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Friday, March 10, 2006 9:02 PM
Subject: tardive vs. levodopa induced dyskinesias


> Antipsychotics and levodopa are the only compounds as
> far as i know that are known to cause dyskinesia.
> Antipsychotics, also called neuroleptics, cause what
> are called tardive dyskinesias (TDs), and levodopa
> causes the various types of levodopa-induced
> dyskinesias (LIDs).
>
> The main difference between tardive and l-dopa induced
> dyskinesias is that the former is "potentially"
> irreversible (presumably the more developed they are
> the less likely they are to go away even if treatment
> is stopped) and the latter is not considered permanent
> because they stop if treatment is stopped.
>
> But honestly - short of having DBS, does anyone ever
> go off l-dopa? As long as one has no choice but to
> remain on l-dopa, dyskinesias are, practically
> speaking, permanent. So, from that perspective they
> can be said to be comparable.
>
> i wanted to provide some sense of how disabling each
> type dyskinesia is capable of becoming, and with what
> frequency, but i could not find any studies/abstracts
> comparing the two.
>
> However, there is one way in which the two are
> quantifiably different - LIDs are a *much* bigger risk
> than TDs - with, according to one study, the 7 year
> risk of developing TDs being 35% (on an old
> neuroleptic - there are newer ones that are less
> likely to cause TDs), while according to another study
> the 10 year risk is just 11.4% - vs. the 5-year risk
> of developing LIDs being anywhere from 50-100%,
> depending on one's age and which study one cites.
>
> And yet, in spite of a much bigger risk of LIDs, a
> mere 47 words are devoted to dyskinesias in the
> Sinemet labeling (in one section, one is instructed to
> call one's physician if one starts experiencing
> involuntary movements or nausea), whereas Navane, and
> old neuroleptic, devotes 535 in three different
> sections to TDs, including the first paragraph in the
> "WARNING" section, and Zybrexa, a new neuroleptic,
> devotes 365.
>
> i would like to know why that is.
>
>
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