David,

In 2000 My first half/dose of a 50/200 (I think) pill worked great, but
never again, even though I continued with 3 pills a day for a year.  Yes, I
tried CR, carbo/levadopa and again in 2003 after my DBS tried Comtan and
Sinemet and the generic to no avail.   Crazy, huh? Since I couldn't see any
benefit and in my trials after DBS started getting abdominal twitching with
no concomitant improvement in movement I couldn't see the point in taking
it.  But that first half dose really made me think it would work.  I still
have some 50/200 pills with a discard date of 11-06 so who knows I might
break a pill in half and try it again, but I don't  like those twitches,
they stopped when I stopped the medication after trying it again in 2005 for
my new neuro in AZ.
Ray---- Original Message -----
From: "DAVID LEWIN" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, March 27, 2006 7:20 AM
Subject: Re: Parkinson's Disease May Be Treated By Electric Current


> Dear Ray,
> How high was the dossage of Sinemet that you took?  How long did you take
> Sinemet?   Have you ever gone back and taken it again?  In the early
> stages
> of my PD, Sinemet had NO Effect on my functionality.  I stopped taking it.
> It was only later when I returned to taking it at a high dossage (25/100
> ten
> pills a day) that I noticed that effected my body.  Regards, David
>
>
>>From: rayilynlee <[log in to unmask]>
>>Reply-To: Parkinson's Information Exchange Network
>><[log in to unmask]>
>>To: [log in to unmask]
>>Subject: Re: Parkinson's Disease May Be Treated By Electric Current
>>Date: Sun, 26 Mar 2006 13:19:57 -0700
>>
>>thanks Maryse, this sounds less intrusive than DBS.  I always wondered why
>>electricity could help my tremors (which are returning I'm sorry to
>>report)
>>when I lack dopamine. Ray
>>----- Original Message -----
>>From: "M.Schild" <[log in to unmask]>
>>To: <[log in to unmask]>
>>Sent: Saturday, March 25, 2006 11:18 PM
>>Subject: Parkinson's Disease May Be Treated By Electric Current
>>
>>
>>>Parkinson's Disease May Be Treated By Electric Current
>>>This Article
>>>Also Appears In
>>>Neurology/Neuroscience
>>>
>>>Article Date: 25 Mar 2006 - 0:00am (UK)
>>>
>>>A simple and efficient method that facilitates Parkinson's disease
>>>treatment
>>>has been developed by researchers of the Institute of Human Brain,
>>>Russian
>>>Academy of Sciences. Influence of feeble electric current on the brain
>>>via
>>>electrodes laid on the head skin - the so-called transcranial electric
>>>polarization (TCEP) - reduces muscle tone and partially restores
>>>patients'
>>>movements. In combination with antiparkinsonian drug intake, TCEP reduces
>>>their side effect.
>>>
>>>Parkinson's disease is a chronic progressive degenerative disease of the
>>>central nervous system. Its main symptoms are - voluntary movements
>>>disorder,
>>>increased muscle tone (rigidity) and trembling (tremor). The disease was
>>>for
>>>the first time described by an English physician James Parkinson in 1817
>>>in
>>>his "Essay on Shaking Palsy". The origin of the disease has not been
>>>fully
>>>investigated yet.
>>>
>>>Today, Parkinson's disease is no longer the destiny of elderly people,
>>>young
>>>people become increasingly its victims. This was declared by Igor
>>>Zavolokov,
>>>head of neurology department, clinics of the Institute of Human Brain,
>>>Russian Academy of Sciences. According to him, such conclusion was made
>>>by
>>>the St. Petersburg neurologists based on their experience of patient
>>>management. "Parkinson's disease is rather widespread, said the
>>>physician,
>>>about 1 percent of people older than 60 and about 5 percent of people
>>>older
>>>than 80 suffer from it, however, recently the disease is more and more
>>>often
>>>registered with the 30-year old patients. Not long ago, a 19-year old
>>>girl
>>>was diagnosed with this disease." According to the researchers' opinion,
>>>this
>>>situation is due to increasing negative impact of the environment and
>>>genetic
>>>anomalies accumulation.
>>>
>>>The drugs that parkinsonism patients have to take lifelong often have
>>>strong
>>>side effects and therefore do not relieve the patient's state too much.
>>>Besides, the drugs lose their effectiveness with time. That is why
>>>researchers and physicians are in constant search for new remedies.
>>>
>>>Transcranial electric polarization may become one of such remedies,
>>>according
>>>to the opinion of researchers from the Institute of Human Brain, Russian
>>>Academy of Sciences, St. Petersburg. The experimental group involved 110
>>>patients with stages of Parkinson's disease from 1 to 4, 80 patients were
>>>included in the main group where TCEP was applied, and the remaining 30
>>>made
>>>the reference group and received only drugs. The patients from the main
>>>group
>>>did not give up the drugs either but in addition they received three to
>>>four
>>>sessions of electric therapy every other day. Continuous current of 2
>>>milliampere acted for 15 minutes via cathode and anode on the head skin.
>>>The
>>>patients' state was assessed judging by intensity of main symptoms -
>>>movement
>>>rate, muscle tone and tremor - prior to the sessions and after them.
>>>
>>>According to physicians' observations, TCEP application resulted in
>>>reduction
>>>of reduntant muscle tone, increase in movement rate and also decrease of
>>>drug's side effects. The only thing TCEP had no influence on was tremor.
>>>Nevertheless, these are considerable results. Effectiveness of procedure
>>>influence on movements and muscle tone varied from 100 to 63.3 percent
>>>depending on the stage of disease. The TCEP session effect remained for
>>>half
>>>a year to a year.
>>>
>>>INFORMNAUKA (INFORMSCIENCE) AGENCY
>>>http://www.informnauka.ru
>>>
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