Yep!

----- Original Message -----
From: "rayilynlee" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Tuesday, May 05, 2009 9:45 AM
Subject: Re: Question re milk thistle


> gee, I didn't know milk thistle would help my liver produce dopamine.  I
> started taking it for constipation.  Do I need to take tyrosine with it?
>
> Ray
>
> Rayilyn Brown
> Director AZNPF
> Arizona Chapter National Parkinson Foundation
> [log in to unmask]
>
> --------------------------------------------------
> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent: Tuesday, May 05, 2009 8:40 AM
> To: <[log in to unmask]>
> Subject: Question re Amantadine/  GSH importance
>
> > Couple of thoughts.
> > Have you tried to let your liver produce your dopamine needs by taking
> > tyrosine and milk thistle?
> > The natural production of GSH  by the body is a little more complicated
> > but
> > following is article from my archives that helps explain.
> >      WHY GSH
> > Oxidative stress appears to play an important role in degeneration of
> > dopaminergic neurons of the substantia nigra (SN) associated with
> > Parkinson's disease (PD). The SN of early PD patients have dramatically
> > decreased levels of the thiol tripeptide glutathione (GSH). GSH plays
> > multiple roles in the nervous system both as an antioxidant and a redox
> > modulator. We have generated dopaminergic PC12 cell lines in which
levels
> > of
> > GSH can be inducibly down-regulated via doxycycline induction of
antisense
> > messages against both the heavy and light subunits of
> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
> > glutathione
> > synthesis. Down-regulation of glutamyl-cysteine synthetase results in
> > reduction in mitochondrial GSH levels, increased oxidative stress, and
> > decreased mitochondrial function. Interestingly, decreases in
> > mitochondrial
> > activities in GSH-depleted PC12 cells appears to be because of a
selective
> > inhibition of complex I activity as a result of thiol oxidation. These
> > results suggest that the early observed GSH losses in the SN may be
> > directly
> > responsible for the noted decreases in complex I activity and the
> > subsequent
> > mitochondrial dysfunction, which ultimately leads to dopaminergic cell
> > death
> > associated with PD.
> >
> >   WHY GLUTAMINE
> > Glutamine is an important mitochondrial substrate implicated in the
> > protection of cells from oxidant injury. Human pulmonary epithelial-like
> > (A549) cells were exposed to 95% O(2) for 4 days in the absence and
> > presence
> > of glutamine. Cell proliferation in normoxia was dependent on glutamine,
> > and
> > glutamine deprivation markedly accelerated cell death in hyperoxia.
> > Glutamine significantly increased cellular ATP levels in normoxia and
> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived cells.
> > Mitochondrial membrane potential as assessed by flow cytometry with
> > chloromethyltetramethylrosamine was increased by glutamine in
> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent increase in
> > mitochondrial membrane potential was detected. Glutamine-supplemented,
> > hyperoxia-exposed cells had a HIGHER  O(2) consumption rate and GSH
> > content.
> > Electron and fluorescence microscopy revealed that, in hyperoxia,
> > glutamine
> > protected cellular structures, especially mitochondria, from damage. In
> > hyperoxia, activity of the tricarboxylic acid cycle enzyme
> > alpha-ketoglutarate dehydrogenase was partially protected by its
indirect
> > substrate, glutamine, indicating a mechanism of mitochondrial
protection.
> > THEREFORE:  I take L-Glutamine and DHEA to increase the level of GSH in
> > the
> > body naturally to further thwart the symptoms and destruction of P.D.
> > along
> > with my other vitamin/mineral protocol which exclude PD drugs. As a
note.
> > I
> > never tried the Amantadine. My doctors forced me early to look elsewhere
> > for
> > help since they couldnt due to lack of knowledge or incentive. Not sure
> > which but I'm alot healthier for switching to a no drug protocol.
> >
> > ----- Original Message -----
> > From: "Ernesto Divo" <[log in to unmask]>
> > To: <[log in to unmask]>
> > Sent: Sunday, May 03, 2009 12:24 PM
> > Subject: Re: Question re Amantadine use
> >
> >
> >> Hi John,
> >>
> >> I'm 56 and was diagnosed with PD in 2000, I've been taking Azilect and
> >> Requip (Ropinirole) the nausea form the Requip is unbearable.  I have
> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', a
> > supplement
> >> developed here in the US, by a US scientist and sold by a US
> >> company. It raises thet levels of GSH in your cells naturally. It took
> >> the
> >> GXL about a week to work on my sleeping pattern, I was waking up 2-3
> >> times
> >> during the night, now I sleep straight thru the night, and it took
about
> >> three weeks to work on my cognitive process but it was so subtle I
barely
> >> thought it was the GXL. I wasn't having problems looking for words to
> > finish
> >> a sentence, my memory is back, I don't lose things around the house, I
> > have
> >> more energy and I feel good and my wife is happier.  It is strange,
when
> >> I
> >> asked my doctor about it he said Gluta what?  it seems the medical
> > community
> >> is keeping the use of Glutathione (GSH) under wraps, they don't want
> >> competition...  I order mine from www.maxgxl.com/133282  I suggest
> >> getting
> >> as much info as possible of GSH, I went to www.youtube.com and searched
> > for
> >> 'The mother of all antioxidants', there is this doctor Mark Hyman who
> >> explains in details about GSH; excellent video.
> >>
> >> Good luck to you.
> >>
> >> Ernesto,
> >> Miami, FL
> >>
> >> On Sat, May 2, 2009 at 11:46 AM, john emrys <[log in to unmask]>
> > wrote:
> >>
> >> > Hey John
> >> >
> >> > I've been on Amantadine since being diagnosed in October of last
year;
> >> > dosage has remained constant and titrated from 100mg to 300mg per
day,
> > over
> >> > an initial period of 3 weeks.
> >> >
> >> > I space the dosing about 5-ish hours apart; I've found if the final
> >> > dose
> > of
> >> > 100mg is taken later than 8PM, I have trouble sleeping through the
> > night.
> >> >
> >> > It does give me an energy boost and some minor relief from muscle
> >> > tightness, but does nothing to improve gait or reduce tremor. It's
sort
> > of
> >> > just a little bit of "gas" for your "engine."
> >> >
> >> > On the other hand, I find it causes auditory hallucinations,
> >> > drowsiness,
> >> > occasional vertigo, foggy thought processing and swelling around the
> > knees.
> >> >
> >> > I find much better results on GSH and mucuna bean, which I started
> >> > about
> > 6
> >> > months ago (the mucuna has been a very recent thing, so it's been too
> > early
> >> > to tell – but so far, I'm definitely impressed). My neuro practically
> > lit
> >> > his own hair on fire when I told him, but he couldn't deny the
results
> > of
> >> > the GSH.
> >> >
> >> > The goal is to be able to cut the amantadine by 35 - 50% within 6
> > months.
> >> > My view is the longer I stay away from starting the agonists, the
> > better.
> >> >
> >> > Hope that helps.
> >> >
> >> >
> >> >
> >> > Joh
> >> >
> >> >
> >>
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