Roberta

I don't take any MAO inhibitors or much else so the tyrosine is most likely
OK for me. thanks for clarifying the issue. It would be great if I could
lose some fat.
Ray
Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]

--------------------------------------------------
From: <[log in to unmask]>
Sent: Sunday, May 10, 2009 8:23 AM
To: <[log in to unmask]>
Subject: Re: Question re milk thistleand tyrosine

>
>
> The following taken from "Prescription for Nutritional Healing" Third
> Edition:
>
> "Tyrosine is important to overall metabolism. It is a precursor of
> adrenaline and the neurotransmiters norepinephrine and dopamine, which
> regulate
> mood and stimulate metabolism and the nervous system. Tyrosine acts as a
> mood elevator; a lack of adequate amounts of tyrosine leads to a
> deficiency
> of norepinephrine in the brain, which in turn can result in depression.
> It
> also acts as a mild antioxidant, suppresses the appetite, and helps to
> reduce body fat. It aids in the production of melanin (the pigment
> responsible
> for skin and hair color) and in the functions of the adrenal, thyroid,
> and
> pituitary glands. It is also involved in the metabolism of the amino
> acid
> phenylalanine.
>
> Tyrosine attaches to iodine atoms to form active thyroid hormones. Not
> surprisingly, therefore, low plasma levels of tyrosine have been
> associated
> with hypothyroidism. Symptoms of tyrosine deficiency can also include
> low
> blood pressure, low body temperature (such as cold hands and feet), and
> restless leg syndrome.
>
> Supplemental L-tyrosine has been used for stress reduction, and research
> suggests it may be helpful against chronic fatigue and narcolepsy. It
> has
> been used to help individuals suffering from anxiety, depression, low sex
> drive, allergies, and headaches, as well as persons undergoing withdrawal
> from drugs. It may also help people with Parkinson's disease.
>
> Natural resources of tyrosine include almonds, avocados, bananas, dairy
> products, lima beans, pumpkin seeds, and sesame seeds. Tyrosine can also
> be
> produced from phenylalanine in the body. Supplements of L-tyrosine
> should
> be taken at bedtime or with a high-carbohydrate meal so that it does not
> have to complete for absorption with other amino acids.
>
> Persons taking monoamine oxidase (MAO)) inhibitors, commonly prescribed
> for depression, must strictly limit their intake of foods containing
> tyrosine
> and should not take any supplements containing L-tyrosine, as it may lead
> to a sudden and dangerous rise in blood pressure. Anyone who takes
> prescription medication for depression should discuss necessary dietary
> restrictions with his or her physician."
>
> I take Azilect which is an MOA (B) not (A) inhibitor so I don't know if
> the last paragraph would apply as I obviously don't take it for
> depression
> but for PD. I guess I'll need to research further unless anyone on this
> forum knows the answer.
>
> Roberta Innarella
>
>
> In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time,
> [log in to unmask] writes:
>
> Schaff:
>
> I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the
> correct
> amount or not?
> thanks so much and for clarifying the bp issue. I couldn't find
> anything
>
> on line that said tyrosine caused high bp - and yes it did claim these 2
> supplements as treatment for PD. thanks so very much
>
> here's hoping....I don't take PD meds you know, but am getting worse
>
> Ray
>
> Rayilyn Brown
> Director AZNPF
> Arizona Chapter National Parkinson Foundation
> [log in to unmask]
>
> --------------------------------------------------
> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent: Sunday, May 10, 2009 8:09 PM
> To: <[log in to unmask]>
> Subject: Re: Question re milk thistleand tyrosine
>
>> To the best of my knowledge tyrosine has no impact on blood pressure. It
>> is
>> a precursor necessary for the production of dopamine by the liver. It is
>> quite beneficial. Salt and sugar as well as poor diets have more impact
> on
>> BP .
>> Hope this helps.
>> If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of
>> walking I've been doing the last few days fixing storm damage on the
> ranch
>> fences. Needless to say by sundown I'm really wornout for the day.
>> Have a good Sunday Ray.
>>
>> ----- Original Message -----
>> From: "rayilynlee" <[log in to unmask]>
>> To: <[log in to unmask]>
>> Sent: Friday, May 08, 2009 10:48 AM
>> Subject: Re: Question re milk thistle
>>
>>
>>> thanks Roberta - I take bp medication
>>> Ray
>>>
>>> Rayilyn Brown
>>> Director AZNPF
>>> Arizona Chapter National Parkinson Foundation
>>> [log in to unmask]
>>>
>>> --------------------------------------------------
>>> From: <[log in to unmask]>
>>> Sent: Thursday, May 07, 2009 4:03 AM
>>> To: <[log in to unmask]>
>>> Subject: Re: Question re milk thistle
>>>
>>> >
>>> >
>>> > Doesn't Tyrosine increase blood pressure?
>>> >
>>> > Roberta Innarella
>>> >
>>> >
>>> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
>>> > [log in to unmask] writes:
>>> >
>>> > Yep!
>>> >
>>> > ----- Original Message -----
>>> > From: "rayilynlee" <[log in to unmask]>
>>> > To: <[log in to unmask]>
>>> > Sent: Tuesday, May 05, 2009 9:45 AM
>>> > Subject: Re: Question re milk thistle
>>> >
>>> >
>>> >> gee, I didn't know milk thistle would help my liver produce
> dopamine.
>>> >> I
>>> >> started taking it for constipation. Do I need to take tyrosine
>>> >> with
>> it?
>>> >>
>>> >> Ray
>>> >>
>>> >> Rayilyn Brown
>>> >> Director AZNPF
>>> >> Arizona Chapter National Parkinson Foundation
>>> >> [log in to unmask]
>>> >>
>>> >> --------------------------------------------------
>>> >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
>>> >> Sent: Tuesday, May 05, 2009 8:40 AM
>>> >> To: <[log in to unmask]>
>>> >> Subject: Question re Amantadine/ GSH importance
>>> >>
>>> >> > Couple of thoughts.
>>> >> > Have you tried to let your liver produce your dopamine needs by
>> taking
>>> >> > tyrosine and milk thistle?
>>> >> > The natural production of GSH by the body is a little more
>>> > complicated
>>> >> > but
>>> >> > following is article from my archives that helps explain.
>>> >> > WHY GSH
>>> >> > Oxidative stress appears to play an important role in
>>> >> > degeneration
>> of
>>> >> > dopaminergic neurons of the substantia nigra (SN) associated
>>> >> with
>>> >> > Parkinson's disease (PD). The SN of early PD patients have
>>> >> > dramatically
>>> >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH
>> plays
>>> >> > multiple roles in the nervous system both as an antioxidant and
>>> a
>>> >> > redox
>>> >> > modulator. We have generated dopaminergic PC12 cell lines in
> which
>>> > levels
>>> >> > of
>>> >> > GSH can be inducibly down-regulated via doxycycline induction of
>>> > antisense
>>> >> > messages against both the heavy and light subunits of
>>> >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
>>> >> > glutathione
>>> >> > synthesis. Down-regulation of glutamyl-cysteine synthetase
>>> >> > results
>> in
>>> >> > reduction in mitochondrial GSH levels, increased oxidative
> stress,
>> and
>>> >> > decreased mitochondrial function. Interestingly, decreases in
>>> >> > mitochondrial
>>> >> > activities in GSH-depleted PC12 cells appears to be because of a
>>> > selective
>>> >> > inhibition of complex I activity as a result of thiol oxidation.
>> These
>>> >> > results suggest that the early observed GSH losses in the SN may
>>> >> > be
>>> >> > directly
>>> >> > responsible for the noted decreases in complex I activity and the
>>> >> > subsequent
>>> >> > mitochondrial dysfunction, which ultimately leads to dopaminergic
>>> >> cell
>>> >> > death
>>> >> > associated with PD.
>>> >> >
>>> >> > WHY GLUTAMINE
>>> >> > Glutamine is an important mitochondrial substrate implicated in
> the
>>> >> > protection of cells from oxidant injury. Human pulmonary
>>> > epithelial-like
>>> >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence
> and
>>> >> > presence
>>> >> > of glutamine. Cell proliferation in normoxia was dependent on
>>> > glutamine,
>>> >> > and
>>> >> > glutamine deprivation markedly accelerated cell death in
> hyperoxia.
>>> >> > Glutamine significantly increased cellular ATP levels in normoxia
>> and
>>> >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived
>>> > cells.
>>> >> > Mitochondrial membrane potential as assessed by flow cytometry
> with
>>> >> > chloromethyltetramethylrosamine was increased by glutamine in
>>> >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent
>> increase
>>> > in
>>> >> > mitochondrial membrane potential was detected.
>> Glutamine-supplemented,
>>> >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and
> GSH
>>> >> > content.
>>> >> > Electron and fluorescence microscopy revealed that, in
> hyperoxia,
>>> >> > glutamine
>>> >> > protected cellular structures, especially mitochondria, from
>>> >> > damage.
>>> >> > In
>>> >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme
>>> >> > alpha-ketoglutarate dehydrogenase was partially protected by
>>> >> > its
>>> > indirect
>>> >> > substrate, glutamine, indicating a mechanism of mitochondrial
>>> > protection.
>>> >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of
>>> >> > GSH
>>> >> > in
>>> >> > the
>>> >> > body naturally to further thwart the symptoms and destruction of
>> P.D.
>>> >> > along
>>> >> > with my other vitamin/mineral protocol which exclude PD drugs. As
> a
>>> > note.
>>> >> > I
>>> >> > never tried the Amantadine. My doctors forced me early to look
>>> > elsewhere
>>> >> > for
>>> >> > help since they couldnt due to lack of knowledge or incentive.
> Not
>>> >> > sure
>>> >> > which but I'm alot healthier for switching to a no drug
> protocol.
>>> >> >
>>> >> > ----- Original Message -----
>>> >> > From: "Ernesto Divo" <[log in to unmask]>
>>> >> > To: <[log in to unmask]>
>>> >> > Sent: Sunday, May 03, 2009 12:24 PM
>>> >> > Subject: Re: Question re Amantadine use
>>> >> >
>>> >> >
>>> >> >> Hi John,
>>> >> >>
>>> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking
> Azilect
>>> >> >> and
>>> >> >> Requip (Ropinirole) the nausea form the Requip is unbearable.
>>> >> >> I
>> have
>>> >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL',
> a
>>> >> > supplement
>>> >> >> developed here in the US, by a US scientist and sold by a US
>>> >> >> company. It raises thet levels of GSH in your cells naturally.
>>> >> >> It
>>> >> >> took
>>> >> >> the
>>> >> >> GXL about a week to work on my sleeping pattern, I was waking
>>> >> up
>> 2-3
>>> >> >> times
>>> >> >> during the night, now I sleep straight thru the night, and it
> took
>>> > about
>>> >> >> three weeks to work on my cognitive process but it was so
> subtle
>>> >> >> I
>>> > barely
>>> >> >> thought it was the GXL. I wasn't having problems looking for
> words
>> to
>>> >> > finish
>>> >> >> a sentence, my memory is back, I don't lose things around the
>> house,
>>> > I
>>> >> > have
>>> >> >> more energy and I feel good and my wife is happier. It is
>>> >> >> strange,
>>> > when
>>> >> >> I
>>> >> >> asked my doctor about it he said Gluta what? it seems the
>>> >> medical
>>> >> > community
>>> >> >> is keeping the use of Glutathione (GSH) under wraps, they don't
>> want
>>> >> >> competition... I order mine from www.maxgxl.com/133282 I
>>> >> >> suggest
>>> >> >> getting
>>> >> >> as much info as possible of GSH, I went to www.youtube.com and
>>> > searched
>>> >> > for
>>> >> >> 'The mother of all antioxidants', there is this doctor Mark
>>> >> >> Hyman
>> who
>>> >> >> explains in details about GSH; excellent video.
>>> >> >>
>>> >> >> Good luck to you.
>>> >> >>
>>> >> >> Ernesto,
>>> >> >> Miami, FL
>>> >> >>
>>> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys
>> <[log in to unmask]>
>>> >> > wrote:
>>> >> >>
>>> >> >> > Hey John
>>> >> >> >
>>> >> >> > I've been on Amantadine since being diagnosed in October of
>>> >> last
>>> > year;
>>> >> >> > dosage has remained constant and titrated from 100mg to 300mg
>>> >> >> > per
>>> > day,
>>> >> > over
>>> >> >> > an initial period of 3 weeks.
>>> >> >> >
>>> >> >> > I space the dosing about 5-ish hours apart; I've found if the
>> final
>>> >> >> > dose
>>> >> > of
>>> >> >> > 100mg is taken later than 8PM, I have trouble sleeping
>>> >> >> through
>> the
>>> >> > night.
>>> >> >> >
>>> >> >> > It does give me an energy boost and some minor relief from
>> muscle
>>> >> >> > tightness, but does nothing to improve gait or reduce tremor.
>> It's
>>> > sort
>>> >> > of
>>> >> >> > just a little bit of "gas" for your "engine."
>>> >> >> >
>>> >> >> > On the other hand, I find it causes auditory hallucinations,
>>> >> >> > drowsiness,
>>> >> >> > occasional vertigo, foggy thought processing and swelling
> around
>>> > the
>>> >> > knees.
>>> >> >> >
>>> >> >> > I find much better results on GSH and mucuna bean, which I
>> started
>>> >> >> > about
>>> >> > 6
>>> >> >> > months ago (the mucuna has been a very recent thing, so it's
>>> >> >> > been
>>> > too
>>> >> > early
>>> >> >> > to tell – but so far, I'm definitely impressed). My neuro
>>> > practically
>>> >> > lit
>>> >> >> > his own hair on fire when I told him, but he couldn't deny
> the
>>> > results
>>> >> > of
>>> >> >> > the GSH.
>>> >> >> >
>>> >> >> > The goal is to be able to cut the amantadine by 35 - 50%
> within
>>> >> >> > 6
>>> >> > months.
>>> >> >> > My view is the longer I stay away from starting the agonists,
>> the
>>> >> > better.
>>> >> >> >
>>> >> >> > Hope that helps.
>>> >> >> >
>>> >> >> >
>>> >> >> >
>>> >> >> > Joh
>>> >> >> >
>>> >> >> >
>>> >> >>
>>>
>>> >> >
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