Has anyone had any luck with CoQenzyme 10 ?  I heard large doses 1200 + mg daily might slow progression of PD

 

Suzanne










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> Date: Sun, 10 May 2009 11:23:31 -0400
> From: [log in to unmask]
> Subject: Re: Question re milk thistleand tyrosine
> To: [log in to unmask]
> 
> 
> 
> 
> The following taken from "Prescription for Nutritional Healing" Third 
> Edition:
> 
> "Tyrosine is important to overall metabolism. It is a precursor of 
> adrenaline and the neurotransmiters norepinephrine and dopamine, which regulate 
> mood and stimulate metabolism and the nervous system. Tyrosine acts as a 
> mood elevator; a lack of adequate amounts of tyrosine leads to a deficiency 
> of norepinephrine in the brain, which in turn can result in depression. It 
> also acts as a mild antioxidant, suppresses the appetite, and helps to 
> reduce body fat. It aids in the production of melanin (the pigment responsible 
> for skin and hair color) and in the functions of the adrenal, thyroid, and 
> pituitary glands. It is also involved in the metabolism of the amino acid 
> phenylalanine.
> 
> Tyrosine attaches to iodine atoms to form active thyroid hormones. Not 
> surprisingly, therefore, low plasma levels of tyrosine have been associated 
> with hypothyroidism. Symptoms of tyrosine deficiency can also include low 
> blood pressure, low body temperature (such as cold hands and feet), and 
> restless leg syndrome.
> 
> Supplemental L-tyrosine has been used for stress reduction, and research 
> suggests it may be helpful against chronic fatigue and narcolepsy. It has 
> been used to help individuals suffering from anxiety, depression, low sex 
> drive, allergies, and headaches, as well as persons undergoing withdrawal 
> from drugs. It may also help people with Parkinson's disease.
> 
> Natural resources of tyrosine include almonds, avocados, bananas, dairy 
> products, lima beans, pumpkin seeds, and sesame seeds. Tyrosine can also be 
> produced from phenylalanine in the body. Supplements of L-tyrosine should 
> be taken at bedtime or with a high-carbohydrate meal so that it does not 
> have to complete for absorption with other amino acids.
> 
> Persons taking monoamine oxidase (MAO)) inhibitors, commonly prescribed 
> for depression, must strictly limit their intake of foods containing tyrosine 
> and should not take any supplements containing L-tyrosine, as it may lead 
> to a sudden and dangerous rise in blood pressure. Anyone who takes 
> prescription medication for depression should discuss necessary dietary 
> restrictions with his or her physician."
> 
> I take Azilect which is an MOA (B) not (A) inhibitor so I don't know if 
> the last paragraph would apply as I obviously don't take it for depression 
> but for PD. I guess I'll need to research further unless anyone on this 
> forum knows the answer.
> 
> Roberta Innarella
> 
> 
> In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time, 
> [log in to unmask] writes:
> 
> Schaff:
> 
> I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the 
> correct 
> amount or not?
> thanks so much and for clarifying the bp issue. I couldn't find anything 
> 
> on line that said tyrosine caused high bp - and yes it did claim these 2 
> supplements as treatment for PD. thanks so very much
> 
> here's hoping....I don't take PD meds you know, but am getting worse
> 
> Ray
> 
> Rayilyn Brown
> Director AZNPF
> Arizona Chapter National Parkinson Foundation
> [log in to unmask]
> 
> --------------------------------------------------
> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent: Sunday, May 10, 2009 8:09 PM
> To: <[log in to unmask]>
> Subject: Re: Question re milk thistleand tyrosine
> 
> > To the best of my knowledge tyrosine has no impact on blood pressure. It 
> > is
> > a precursor necessary for the production of dopamine by the liver. It is
> > quite beneficial. Salt and sugar as well as poor diets have more impact 
> on
> > BP .
> > Hope this helps.
> > If it werent for tyrosine in my program I couldnt do the 5 to 6 hours of
> > walking I've been doing the last few days fixing storm damage on the 
> ranch
> > fences. Needless to say by sundown I'm really wornout for the day.
> > Have a good Sunday Ray.
> >
> > ----- Original Message -----
> > From: "rayilynlee" <[log in to unmask]>
> > To: <[log in to unmask]>
> > Sent: Friday, May 08, 2009 10:48 AM
> > Subject: Re: Question re milk thistle
> >
> >
> >> thanks Roberta - I take bp medication
> >> Ray
> >>
> >> Rayilyn Brown
> >> Director AZNPF
> >> Arizona Chapter National Parkinson Foundation
> >> [log in to unmask]
> >>
> >> --------------------------------------------------
> >> From: <[log in to unmask]>
> >> Sent: Thursday, May 07, 2009 4:03 AM
> >> To: <[log in to unmask]>
> >> Subject: Re: Question re milk thistle
> >>
> >> >
> >> >
> >> > Doesn't Tyrosine increase blood pressure?
> >> >
> >> > Roberta Innarella
> >> >
> >> >
> >> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
> >> > [log in to unmask] writes:
> >> >
> >> > Yep!
> >> >
> >> > ----- Original Message -----
> >> > From: "rayilynlee" <[log in to unmask]>
> >> > To: <[log in to unmask]>
> >> > Sent: Tuesday, May 05, 2009 9:45 AM
> >> > Subject: Re: Question re milk thistle
> >> >
> >> >
> >> >> gee, I didn't know milk thistle would help my liver produce 
> dopamine.
> >> >> I
> >> >> started taking it for constipation. Do I need to take tyrosine with
> > it?
> >> >>
> >> >> Ray
> >> >>
> >> >> Rayilyn Brown
> >> >> Director AZNPF
> >> >> Arizona Chapter National Parkinson Foundation
> >> >> [log in to unmask]
> >> >>
> >> >> --------------------------------------------------
> >> >> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> >> >> Sent: Tuesday, May 05, 2009 8:40 AM
> >> >> To: <[log in to unmask]>
> >> >> Subject: Question re Amantadine/ GSH importance
> >> >>
> >> >> > Couple of thoughts.
> >> >> > Have you tried to let your liver produce your dopamine needs by
> > taking
> >> >> > tyrosine and milk thistle?
> >> >> > The natural production of GSH by the body is a little more
> >> > complicated
> >> >> > but
> >> >> > following is article from my archives that helps explain.
> >> >> > WHY GSH
> >> >> > Oxidative stress appears to play an important role in degeneration
> > of
> >> >> > dopaminergic neurons of the substantia nigra (SN) associated with
> >> >> > Parkinson's disease (PD). The SN of early PD patients have
> >> >> > dramatically
> >> >> > decreased levels of the thiol tripeptide glutathione (GSH). GSH
> > plays
> >> >> > multiple roles in the nervous system both as an antioxidant and a
> >> >> > redox
> >> >> > modulator. We have generated dopaminergic PC12 cell lines in 
> which
> >> > levels
> >> >> > of
> >> >> > GSH can be inducibly down-regulated via doxycycline induction of
> >> > antisense
> >> >> > messages against both the heavy and light subunits of
> >> >> > gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
> >> >> > glutathione
> >> >> > synthesis. Down-regulation of glutamyl-cysteine synthetase results
> > in
> >> >> > reduction in mitochondrial GSH levels, increased oxidative 
> stress,
> > and
> >> >> > decreased mitochondrial function. Interestingly, decreases in
> >> >> > mitochondrial
> >> >> > activities in GSH-depleted PC12 cells appears to be because of a
> >> > selective
> >> >> > inhibition of complex I activity as a result of thiol oxidation.
> > These
> >> >> > results suggest that the early observed GSH losses in the SN may 
> >> >> > be
> >> >> > directly
> >> >> > responsible for the noted decreases in complex I activity and the
> >> >> > subsequent
> >> >> > mitochondrial dysfunction, which ultimately leads to dopaminergic
> >> >> cell
> >> >> > death
> >> >> > associated with PD.
> >> >> >
> >> >> > WHY GLUTAMINE
> >> >> > Glutamine is an important mitochondrial substrate implicated in 
> the
> >> >> > protection of cells from oxidant injury. Human pulmonary
> >> > epithelial-like
> >> >> > (A549) cells were exposed to 95% O(2) for 4 days in the absence 
> and
> >> >> > presence
> >> >> > of glutamine. Cell proliferation in normoxia was dependent on
> >> > glutamine,
> >> >> > and
> >> >> > glutamine deprivation markedly accelerated cell death in 
> hyperoxia.
> >> >> > Glutamine significantly increased cellular ATP levels in normoxia
> > and
> >> >> > prevented the loss of ATP in hyperoxia seen in glutamine-deprived
> >> > cells.
> >> >> > Mitochondrial membrane potential as assessed by flow cytometry 
> with
> >> >> > chloromethyltetramethylrosamine was increased by glutamine in
> >> >> > hyperoxia-exposed A549 cells, and a glutamine dose-dependent
> > increase
> >> > in
> >> >> > mitochondrial membrane potential was detected.
> > Glutamine-supplemented,
> >> >> > hyperoxia-exposed cells had a HIGHER O(2) consumption rate and 
> GSH
> >> >> > content.
> >> >> > Electron and fluorescence microscopy revealed that, in 
> hyperoxia,
> >> >> > glutamine
> >> >> > protected cellular structures, especially mitochondria, from 
> >> >> > damage.
> >> >> > In
> >> >> > hyperoxia, activity of the tricarboxylic acid cycle enzyme
> >> >> > alpha-ketoglutarate dehydrogenase was partially protected by its
> >> > indirect
> >> >> > substrate, glutamine, indicating a mechanism of mitochondrial
> >> > protection.
> >> >> > THEREFORE: I take L-Glutamine and DHEA to increase the level of 
> >> >> > GSH
> >> >> > in
> >> >> > the
> >> >> > body naturally to further thwart the symptoms and destruction of
> > P.D.
> >> >> > along
> >> >> > with my other vitamin/mineral protocol which exclude PD drugs. As 
> a
> >> > note.
> >> >> > I
> >> >> > never tried the Amantadine. My doctors forced me early to look
> >> > elsewhere
> >> >> > for
> >> >> > help since they couldnt due to lack of knowledge or incentive. 
> Not
> >> >> > sure
> >> >> > which but I'm alot healthier for switching to a no drug 
> protocol.
> >> >> >
> >> >> > ----- Original Message -----
> >> >> > From: "Ernesto Divo" <[log in to unmask]>
> >> >> > To: <[log in to unmask]>
> >> >> > Sent: Sunday, May 03, 2009 12:24 PM
> >> >> > Subject: Re: Question re Amantadine use
> >> >> >
> >> >> >
> >> >> >> Hi John,
> >> >> >>
> >> >> >> I'm 56 and was diagnosed with PD in 2000, I've been taking 
> Azilect
> >> >> >> and
> >> >> >> Requip (Ropinirole) the nausea form the Requip is unbearable. I
> > have
> >> >> >> introduced to my regimen for the past 5 months or so, 'MaxGXL', 
> a
> >> >> > supplement
> >> >> >> developed here in the US, by a US scientist and sold by a US
> >> >> >> company. It raises thet levels of GSH in your cells naturally. It
> >> >> >> took
> >> >> >> the
> >> >> >> GXL about a week to work on my sleeping pattern, I was waking up
> > 2-3
> >> >> >> times
> >> >> >> during the night, now I sleep straight thru the night, and it 
> took
> >> > about
> >> >> >> three weeks to work on my cognitive process but it was so 
> subtle 
> >> >> >> I
> >> > barely
> >> >> >> thought it was the GXL. I wasn't having problems looking for 
> words
> > to
> >> >> > finish
> >> >> >> a sentence, my memory is back, I don't lose things around the
> > house,
> >> > I
> >> >> > have
> >> >> >> more energy and I feel good and my wife is happier. It is 
> >> >> >> strange,
> >> > when
> >> >> >> I
> >> >> >> asked my doctor about it he said Gluta what? it seems the 
> >> >> medical
> >> >> > community
> >> >> >> is keeping the use of Glutathione (GSH) under wraps, they don't
> > want
> >> >> >> competition... I order mine from www.maxgxl.com/133282 I 
> >> >> >> suggest
> >> >> >> getting
> >> >> >> as much info as possible of GSH, I went to www.youtube.com and
> >> > searched
> >> >> > for
> >> >> >> 'The mother of all antioxidants', there is this doctor Mark Hyman
> > who
> >> >> >> explains in details about GSH; excellent video.
> >> >> >>
> >> >> >> Good luck to you.
> >> >> >>
> >> >> >> Ernesto,
> >> >> >> Miami, FL
> >> >> >>
> >> >> >> On Sat, May 2, 2009 at 11:46 AM, john emrys
> > <[log in to unmask]>
> >> >> > wrote:
> >> >> >>
> >> >> >> > Hey John
> >> >> >> >
> >> >> >> > I've been on Amantadine since being diagnosed in October of 
> >> >> last
> >> > year;
> >> >> >> > dosage has remained constant and titrated from 100mg to 300mg 
> >> >> >> > per
> >> > day,
> >> >> > over
> >> >> >> > an initial period of 3 weeks.
> >> >> >> >
> >> >> >> > I space the dosing about 5-ish hours apart; I've found if the
> > final
> >> >> >> > dose
> >> >> > of
> >> >> >> > 100mg is taken later than 8PM, I have trouble sleeping through
> > the
> >> >> > night.
> >> >> >> >
> >> >> >> > It does give me an energy boost and some minor relief from
> > muscle
> >> >> >> > tightness, but does nothing to improve gait or reduce tremor.
> > It's
> >> > sort
> >> >> > of
> >> >> >> > just a little bit of "gas" for your "engine."
> >> >> >> >
> >> >> >> > On the other hand, I find it causes auditory hallucinations,
> >> >> >> > drowsiness,
> >> >> >> > occasional vertigo, foggy thought processing and swelling 
> around
> >> > the
> >> >> > knees.
> >> >> >> >
> >> >> >> > I find much better results on GSH and mucuna bean, which I
> > started
> >> >> >> > about
> >> >> > 6
> >> >> >> > months ago (the mucuna has been a very recent thing, so it's 
> >> >> >> > been
> >> > too
> >> >> > early
> >> >> >> > to tell – but so far, I'm definitely impressed). My neuro
> >> > practically
> >> >> > lit
> >> >> >> > his own hair on fire when I told him, but he couldn't deny 
> the
> >> > results
> >> >> > of
> >> >> >> > the GSH.
> >> >> >> >
> >> >> >> > The goal is to be able to cut the amantadine by 35 - 50% 
> within 
> >> >> >> > 6
> >> >> > months.
> >> >> >> > My view is the longer I stay away from starting the agonists,
> > the
> >> >> > better.
> >> >> >> >
> >> >> >> > Hope that helps.
> >> >> >> >
> >> >> >> >
> >> >> >> >
> >> >> >> > Joh
> >> >> >> >
> >> >> >> >
> >> >> >>
> >> 
> >> >> > 
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