Rob

I got the 250 milk thistle.  It seems to me that taking small doses several 
times a day is the way to go.  Why didn't I think of that??   The tyrosine 
should arrive soon.  I'll order some Bs and try your  regime.  Thank you so 
much.

Ray

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]

--------------------------------------------------
From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
Sent: Tuesday, May 12, 2009 12:27 PM
To: <[log in to unmask]>
Subject: Re: Question re milk thistleand tyrosine

> I also do not take any PD meds. I take painkillers periodically from 
> trying
> to stay to active with PD  and a lot of other antioxidants, minerals, and
> vits.
>
> Personally I take 200mg of similar milk thistle three times a day and 
> 500mg
> of L-tyrosine three times a day.  I take low doses multiple times a day to
> aid in maintaining blood levels .  I use small bottles and sort my 
> vitamins
> and minerals out once a month to am, noon's, and pms. This keeps me on 
> track
> for taking them better than any other system I've tried.
> The doses you ordered may just work fine to jump start you "off the couch"
> so to speak. Milk thistle is good for the liver so I cant see the large 
> dose
> being of any concern. Most of my  "drinking" friends finally have started
> taking milk thistle before they go out to avoid the " hangover" so they 
> can
> drink more and party more, I guess. I dont understand that scene but it
> really does help with the aftereffects.
> It has been known for years to cure cerosis of the liver and lately it has
> been found very helpful in stopping mastastisis of breast cancer. So with
> your past history it may long be overdue.  I hope it helps you and dont
> forget to take a few B vitamins along the way too.
> Your friend ,  Rob
>
> ----- Original Message -----
> From: "rayilynlee" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Sunday, May 10, 2009 1:26 AM
> Subject: Re: Question re milk thistleand tyrosine
>
>
>> Schaff:
>>
>> I ordered 1000 msg milk thistle and 500 msg L-tyrosine - is that the
> correct
>> amount or not?
>> thanks so much and for clarifying the bp issue.  I  couldn't find 
>> anything
>> on line that said tyrosine caused high bp - and yes it did claim these 2
>> supplements as treatment for PD.  thanks so very much
>>
>> here's hoping....I don't take PD meds you know, but am getting worse
>>
>> Ray
>>
>> Rayilyn Brown
>> Director AZNPF
>> Arizona Chapter National Parkinson Foundation
>> [log in to unmask]
>>
>> --------------------------------------------------
>> From: "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
>> Sent: Sunday, May 10, 2009 8:09 PM
>> To: <[log in to unmask]>
>> Subject: Re: Question re milk thistleand tyrosine
>>
>> > To the best of my knowledge tyrosine has no impact on blood pressure. 
>> > It
>> > is
>> > a precursor necessary for the production of dopamine by the liver. It 
>> > is
>> > quite beneficial. Salt and sugar as well as poor diets have more impact
> on
>> > BP .
>> > Hope this helps.
>> > If it werent for tyrosine in my program I couldnt do the 5 to 6 hours 
>> > of
>> > walking I've been doing the last few days fixing storm damage on the
> ranch
>> > fences. Needless to say by sundown I'm really wornout for the day.
>> > Have a good Sunday Ray.
>> >
>> > ----- Original Message -----
>> > From: "rayilynlee" <[log in to unmask]>
>> > To: <[log in to unmask]>
>> > Sent: Friday, May 08, 2009 10:48 AM
>> > Subject: Re: Question re milk thistle
>> >
>> >
>> >> thanks Roberta  - I take bp medication
>> >> Ray
>> >>
>> >> Rayilyn Brown
>> >> Director AZNPF
>> >> Arizona Chapter National Parkinson Foundation
>> >> [log in to unmask]
>> >>
>> >> --------------------------------------------------
>> >> From: <[log in to unmask]>
>> >> Sent: Thursday, May 07, 2009 4:03 AM
>> >> To: <[log in to unmask]>
>> >> Subject: Re: Question re milk thistle
>> >>
>> >> >
>> >> >
>> >> > Doesn't Tyrosine increase blood pressure?
>> >> >
>> >> > Roberta Innarella
>> >> >
>> >> >
>> >> > In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
>> >> > [log in to unmask] writes:
>> >> >
>> >> > Yep!
>> >> >
>> >> > ----- Original Message -----
>> >> > From:  "rayilynlee" <[log in to unmask]>
>> >> > To:  <[log in to unmask]>
>> >> > Sent: Tuesday, May 05, 2009  9:45 AM
>> >> > Subject: Re: Question re milk thistle
>> >> >
>> >> >
>> >> >> gee, I  didn't know milk thistle would help my liver produce
> dopamine.
>> >> >> I
>> >> >> started taking it for constipation.  Do I need to take  tyrosine
> with
>> > it?
>> >> >>
>> >> >> Ray
>> >> >>
>> >> >> Rayilyn  Brown
>> >> >> Director AZNPF
>> >> >> Arizona Chapter National Parkinson  Foundation
>> >> >> [log in to unmask]
>> >> >>
>> >> >>  --------------------------------------------------
>> >> >> From: "Schaaf  Angus / Meadow Creek Ranch" <[log in to unmask]>
>> >> >> Sent:  Tuesday, May 05, 2009 8:40 AM
>> >> >> To:  <[log in to unmask]>
>> >> >> Subject: Question re  Amantadine/  GSH importance
>> >> >>
>> >> >> > Couple of  thoughts.
>> >> >> > Have you tried to let your liver produce your  dopamine needs by
>> > taking
>> >> >> > tyrosine and milk thistle?
>> >> >>  > The natural production of GSH  by the body is a little more
>> >> > complicated
>> >> >> > but
>> >> >> > following is article from my  archives that helps explain.
>> >> >> >      WHY  GSH
>> >> >> > Oxidative stress appears to play an important role in
> degeneration
>> > of
>> >> >> > dopaminergic neurons of the substantia  nigra (SN) associated 
>> >> >> > with
>> >> >> > Parkinson's disease (PD). The SN  of early PD patients have
>> >> >> > dramatically
>> >> >> > decreased levels of  the thiol tripeptide glutathione (GSH). GSH
>> > plays
>> >> >> > multiple  roles in the nervous system both as an antioxidant and 
>> >> >> > a
>> >> >> > redox
>> >> >>  > modulator. We have generated dopaminergic PC12 cell lines in
> which
>> >> > levels
>> >> >> > of
>> >> >> > GSH can be inducibly  down-regulated via doxycycline induction of
>> >> > antisense
>> >> >> >  messages against both the heavy and light subunits of
>> >> >> >  gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
>> >> >>  > glutathione
>> >> >> > synthesis. Down-regulation of  glutamyl-cysteine synthetase
> results
>> > in
>> >> >> > reduction in  mitochondrial GSH levels, increased oxidative
> stress,
>> > and
>> >> >> >  decreased mitochondrial function. Interestingly, decreases in
>> >> >>  > mitochondrial
>> >> >> > activities in GSH-depleted PC12 cells  appears to be because of a
>> >> > selective
>> >> >> > inhibition of  complex I activity as a result of thiol oxidation.
>> > These
>> >> >> >  results suggest that the early observed GSH losses in the SN may
>> >> >> > be
>> >> >> > directly
>> >> >> > responsible for the noted  decreases in complex I activity and 
>> >> >> > the
>> >> >> > subsequent
>> >> >>  > mitochondrial dysfunction, which ultimately leads to 
>> >> >> dopaminergic
>> >> >> cell
>> >> >> > death
>> >> >> > associated with PD.
>> >> >>  >
>> >> >> >   WHY GLUTAMINE
>> >> >> > Glutamine is an  important mitochondrial substrate implicated in
> the
>> >> >> >  protection of cells from oxidant injury. Human pulmonary
>> >> > epithelial-like
>> >> >> > (A549) cells were exposed to 95% O(2) for 4  days in the absence
> and
>> >> >> > presence
>> >> >> > of glutamine.  Cell proliferation in normoxia was dependent on
>> >> > glutamine,
>> >> >> >  and
>> >> >> > glutamine deprivation markedly accelerated cell death  in
> hyperoxia.
>> >> >> > Glutamine significantly increased cellular  ATP levels in 
>> >> >> > normoxia
>> > and
>> >> >> > prevented the loss of ATP in  hyperoxia seen in 
>> >> >> > glutamine-deprived
>> >> > cells.
>> >> >> > Mitochondrial  membrane potential as assessed by flow cytometry
> with
>> >> >> >  chloromethyltetramethylrosamine was increased by glutamine in
>> >> >>  > hyperoxia-exposed A549 cells, and a glutamine dose-dependent
>> > increase
>> >> > in
>> >> >> > mitochondrial membrane potential was detected.
>> > Glutamine-supplemented,
>> >> >> > hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate and
> GSH
>> >> >> > content.
>> >> >>  > Electron and fluorescence microscopy revealed that, in
> hyperoxia,
>> >> >> > glutamine
>> >> >> > protected cellular  structures, especially mitochondria, from
>> >> >> > damage.
>> >> >> > In
>> >> >> >  hyperoxia, activity of the tricarboxylic acid cycle enzyme
>> >> >> >  alpha-ketoglutarate dehydrogenase was partially protected by 
>> >> >> > its
>> >> > indirect
>> >> >> > substrate, glutamine, indicating a  mechanism of mitochondrial
>> >> > protection.
>> >> >> > THEREFORE:   I take L-Glutamine and DHEA to increase the level of
>> >> >> > GSH
>> >> >> > in
>> >> >> >  the
>> >> >> > body naturally to further thwart the symptoms and  destruction of
>> > P.D.
>> >> >> > along
>> >> >> > with my other  vitamin/mineral protocol which exclude PD drugs. 
>> >> >> > As
> a
>> >> > note.
>> >> >>  > I
>> >> >> > never tried the Amantadine. My doctors forced me  early to look
>> >> > elsewhere
>> >> >> > for
>> >> >> > help since they  couldnt due to lack of knowledge or incentive.
> Not
>> >> >> > sure
>> >> >> >  which but I'm alot healthier for switching to a no drug
> protocol.
>> >> >> >
>> >> >> > ----- Original Message -----
>> >> >>  > From: "Ernesto Divo" <[log in to unmask]>
>> >> >> > To:  <[log in to unmask]>
>> >> >> > Sent: Sunday, May 03,  2009 12:24 PM
>> >> >> > Subject: Re: Question re Amantadine  use
>> >> >> >
>> >> >> >
>> >> >> >> Hi John,
>> >> >>  >>
>> >> >> >> I'm 56 and was diagnosed with PD in 2000, I've  been taking
> Azilect
>> >> >> >> and
>> >> >> >> Requip (Ropinirole) the nausea  form the Requip is unbearable. 
>> >> >> >> I
>> > have
>> >> >> >> introduced  to my regimen for the past 5 months or so, 'MaxGXL',
> a
>> >> >> >  supplement
>> >> >> >> developed here in the US, by a US scientist  and sold by a US
>> >> >> >> company. It raises thet levels of GSH  in your cells naturally.
> It
>> >> >> >> took
>> >> >> >> the
>> >> >> >>  GXL about a week to work on my sleeping pattern, I was waking 
>> >> >> >> up
>> > 2-3
>> >> >> >> times
>> >> >> >> during the night, now I  sleep straight thru the night, and it
> took
>> >> > about
>> >> >> >>  three weeks to work on my cognitive process but it was so 
>> >> >> >> subtle
>> >> >> >> I
>> >> > barely
>> >> >> >> thought it was the GXL. I wasn't having  problems looking for
> words
>> > to
>> >> >> > finish
>> >> >> >> a  sentence, my memory is back, I don't lose things around the
>> > house,
>> >> > I
>> >> >> > have
>> >> >> >> more energy and I feel good and my  wife is happier.  It is
>> >> >> >> strange,
>> >> > when
>> >> >> >> I
>> >> >>  >> asked my doctor about it he said Gluta what?  it seems the
>> >> >> medical
>> >> >> > community
>> >> >> >> is keeping the use of  Glutathione (GSH) under wraps, they don't
>> > want
>> >> >> >>  competition...  I order mine from www.maxgxl.com/133282  I
>> >> >> >> suggest
>> >> >> >> getting
>> >> >> >> as much info as  possible of GSH, I went to www.youtube.com and
>> >> > searched
>> >> >> >  for
>> >> >> >> 'The mother of all antioxidants', there is this  doctor Mark
> Hyman
>> > who
>> >> >> >> explains in details about GSH;  excellent video.
>> >> >> >>
>> >> >> >> Good luck to  you.
>> >> >> >>
>> >> >> >> Ernesto,
>> >> >> >> Miami,  FL
>> >> >> >>
>> >> >> >> On Sat, May 2, 2009 at 11:46 AM,  john emrys
>> > <[log in to unmask]>
>> >> >> > wrote:
>> >> >>  >>
>> >> >> >> > Hey John
>> >> >> >> >
>> >> >>  >> > I've been on Amantadine since being diagnosed in October  of
>> >> >> last
>> >> > year;
>> >> >> >> > dosage has remained constant and  titrated from 100mg to 300mg
>> >> >> >> > per
>> >> > day,
>> >> >> > over
>> >> >>  >> > an initial period of 3 weeks.
>> >> >> >>  >
>> >> >> >> > I space the dosing about 5-ish hours apart;  I've found if the
>> > final
>> >> >> >> > dose
>> >> >> >  of
>> >> >> >> > 100mg is taken later than 8PM, I have trouble  sleeping 
>> >> >> >> > through
>> > the
>> >> >> > night.
>> >> >> >> >
>> >> >>  >> > It does give me an energy boost and some minor relief from
>> > muscle
>> >> >> >> > tightness, but does nothing to improve gait  or reduce tremor.
>> > It's
>> >> > sort
>> >> >> > of
>> >> >> >> >  just a little bit of "gas" for your "engine."
>> >> >> >>  >
>> >> >> >> > On the other hand, I find it causes auditory  hallucinations,
>> >> >> >> > drowsiness,
>> >> >> >> >  occasional vertigo, foggy thought processing and swelling
> around
>> >> > the
>> >> >> > knees.
>> >> >> >> >
>> >> >> >> > I  find much better results on GSH and mucuna bean, which I
>> > started
>> >> >>  >> > about
>> >> >> > 6
>> >> >> >> > months ago (the  mucuna has been a very recent thing, so it's
>> >> >> >> > been
>> >> > too
>> >> >> >  early
>> >> >> >> > to tell – but so far, I'm definitely  impressed). My neuro
>> >> > practically
>> >> >> > lit
>> >> >> >> >  his own hair on fire when I told him, but he couldn't deny
> the
>> >> > results
>> >> >> > of
>> >> >> >> > the GSH.
>> >> >>  >> >
>> >> >> >> > The goal is to be able to cut the  amantadine by 35 - 50%
> within
>> >> >> >> > 6
>> >> >> > months.
>> >> >> >>  > My view is the longer I stay away from starting the agonists,
>> > the
>> >> >> > better.
>> >> >> >> >
>> >> >> >> >  Hope that helps.
>> >> >> >> >
>> >> >> >> >
>> >> >>  >> >
>> >> >> >> > Joh
>> >> >> >> >
>> >> >>  >> >
>> >> >> >>
>> >>
>> >> >>
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>> >> >>  >>
>> >> >>
>> >> >> >>
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>> >> >
>> >> >
>> >> > **************Remember Mom this Mother's Day! Find a florist near 
>> >> > you
>> > now.
>> >> >
>> >
> (http://yellowpages.aol.com/search?query=florist&ncid=emlcntusyelp00000006)
>> >> >
>> >>
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