thanks Roberta  - I take bp medication
Ray

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]

--------------------------------------------------
From: <[log in to unmask]>
Sent: Thursday, May 07, 2009 4:03 AM
To: <[log in to unmask]>
Subject: Re: Question re milk thistle

>
>
> Doesn't Tyrosine increase blood pressure?
>
> Roberta Innarella
>
>
> In a message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
> [log in to unmask] writes:
>
> Yep!
>
> ----- Original Message -----
> From:  "rayilynlee" <[log in to unmask]>
> To:  <[log in to unmask]>
> Sent: Tuesday, May 05, 2009  9:45 AM
> Subject: Re: Question re milk thistle
>
>
>> gee, I  didn't know milk thistle would help my liver produce dopamine. 
>> I
>> started taking it for constipation.  Do I need to take  tyrosine with it?
>>
>> Ray
>>
>> Rayilyn  Brown
>> Director AZNPF
>> Arizona Chapter National Parkinson  Foundation
>> [log in to unmask]
>>
>>  --------------------------------------------------
>> From: "Schaaf  Angus / Meadow Creek Ranch" <[log in to unmask]>
>> Sent:  Tuesday, May 05, 2009 8:40 AM
>> To:  <[log in to unmask]>
>> Subject: Question re  Amantadine/  GSH importance
>>
>> > Couple of  thoughts.
>> > Have you tried to let your liver produce your  dopamine needs by taking
>> > tyrosine and milk thistle?
>>  > The natural production of GSH  by the body is a little more
> complicated
>> > but
>> > following is article from my  archives that helps explain.
>> >      WHY  GSH
>> > Oxidative stress appears to play an important role in  degeneration of
>> > dopaminergic neurons of the substantia  nigra (SN) associated with
>> > Parkinson's disease (PD). The SN  of early PD patients have 
>> > dramatically
>> > decreased levels of  the thiol tripeptide glutathione (GSH). GSH plays
>> > multiple  roles in the nervous system both as an antioxidant and a 
>> > redox
>>  > modulator. We have generated dopaminergic PC12 cell lines in  which
> levels
>> > of
>> > GSH can be inducibly  down-regulated via doxycycline induction of
> antisense
>> >  messages against both the heavy and light subunits of
>> >  gamma-glutamyl-cysteine synthetase, the rate-limiting enzyme in
>>  > glutathione
>> > synthesis. Down-regulation of  glutamyl-cysteine synthetase results in
>> > reduction in  mitochondrial GSH levels, increased oxidative stress, and
>> >  decreased mitochondrial function. Interestingly, decreases in
>>  > mitochondrial
>> > activities in GSH-depleted PC12 cells  appears to be because of a
> selective
>> > inhibition of  complex I activity as a result of thiol oxidation. These
>> >  results suggest that the early observed GSH losses in the SN may  be
>> > directly
>> > responsible for the noted  decreases in complex I activity and the
>> > subsequent
>>  > mitochondrial dysfunction, which ultimately leads to dopaminergic 
>> cell
>> > death
>> > associated with PD.
>>  >
>> >   WHY GLUTAMINE
>> > Glutamine is an  important mitochondrial substrate implicated in the
>> >  protection of cells from oxidant injury. Human pulmonary
> epithelial-like
>> > (A549) cells were exposed to 95% O(2) for 4  days in the absence and
>> > presence
>> > of glutamine.  Cell proliferation in normoxia was dependent on
> glutamine,
>> >  and
>> > glutamine deprivation markedly accelerated cell death  in hyperoxia.
>> > Glutamine significantly increased cellular  ATP levels in normoxia and
>> > prevented the loss of ATP in  hyperoxia seen in glutamine-deprived
> cells.
>> > Mitochondrial  membrane potential as assessed by flow cytometry with
>> >  chloromethyltetramethylrosamine was increased by glutamine in
>>  > hyperoxia-exposed A549 cells, and a glutamine dose-dependent  increase
> in
>> > mitochondrial membrane potential was detected.  Glutamine-supplemented,
>> > hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate and GSH
>> > content.
>>  > Electron and fluorescence microscopy revealed that, in  hyperoxia,
>> > glutamine
>> > protected cellular  structures, especially mitochondria, from damage. 
>> > In
>> >  hyperoxia, activity of the tricarboxylic acid cycle enzyme
>> >  alpha-ketoglutarate dehydrogenase was partially protected by  its
> indirect
>> > substrate, glutamine, indicating a  mechanism of mitochondrial
> protection.
>> > THEREFORE:   I take L-Glutamine and DHEA to increase the level of GSH 
>> > in
>> >  the
>> > body naturally to further thwart the symptoms and  destruction of P.D.
>> > along
>> > with my other  vitamin/mineral protocol which exclude PD drugs. As a
> note.
>>  > I
>> > never tried the Amantadine. My doctors forced me  early to look
> elsewhere
>> > for
>> > help since they  couldnt due to lack of knowledge or incentive. Not 
>> > sure
>> >  which but I'm alot healthier for switching to a no drug  protocol.
>> >
>> > ----- Original Message -----
>>  > From: "Ernesto Divo" <[log in to unmask]>
>> > To:  <[log in to unmask]>
>> > Sent: Sunday, May 03,  2009 12:24 PM
>> > Subject: Re: Question re Amantadine  use
>> >
>> >
>> >> Hi John,
>>  >>
>> >> I'm 56 and was diagnosed with PD in 2000, I've  been taking Azilect 
>> >> and
>> >> Requip (Ropinirole) the nausea  form the Requip is unbearable.  I have
>> >> introduced  to my regimen for the past 5 months or so, 'MaxGXL', a
>> >  supplement
>> >> developed here in the US, by a US scientist  and sold by a US
>> >> company. It raises thet levels of GSH  in your cells naturally. It 
>> >> took
>> >> the
>> >>  GXL about a week to work on my sleeping pattern, I was waking up  2-3
>> >> times
>> >> during the night, now I  sleep straight thru the night, and it took
> about
>> >>  three weeks to work on my cognitive process but it was so subtle  I
> barely
>> >> thought it was the GXL. I wasn't having  problems looking for words to
>> > finish
>> >> a  sentence, my memory is back, I don't lose things around the house,
> I
>> > have
>> >> more energy and I feel good and my  wife is happier.  It is strange,
> when
>> >> I
>>  >> asked my doctor about it he said Gluta what?  it seems the  medical
>> > community
>> >> is keeping the use of  Glutathione (GSH) under wraps, they don't want
>> >>  competition...  I order mine from www.maxgxl.com/133282  I  suggest
>> >> getting
>> >> as much info as  possible of GSH, I went to www.youtube.com and
> searched
>> >  for
>> >> 'The mother of all antioxidants', there is this  doctor Mark Hyman who
>> >> explains in details about GSH;  excellent video.
>> >>
>> >> Good luck to  you.
>> >>
>> >> Ernesto,
>> >> Miami,  FL
>> >>
>> >> On Sat, May 2, 2009 at 11:46 AM,  john emrys <[log in to unmask]>
>> > wrote:
>>  >>
>> >> > Hey John
>> >> >
>>  >> > I've been on Amantadine since being diagnosed in October  of last
> year;
>> >> > dosage has remained constant and  titrated from 100mg to 300mg per
> day,
>> > over
>>  >> > an initial period of 3 weeks.
>> >>  >
>> >> > I space the dosing about 5-ish hours apart;  I've found if the final
>> >> > dose
>> >  of
>> >> > 100mg is taken later than 8PM, I have trouble  sleeping through the
>> > night.
>> >> >
>>  >> > It does give me an energy boost and some minor relief from  muscle
>> >> > tightness, but does nothing to improve gait  or reduce tremor. It's
> sort
>> > of
>> >> >  just a little bit of "gas" for your "engine."
>> >>  >
>> >> > On the other hand, I find it causes auditory  hallucinations,
>> >> > drowsiness,
>> >> >  occasional vertigo, foggy thought processing and swelling around
> the
>> > knees.
>> >> >
>> >> > I  find much better results on GSH and mucuna bean, which I started
>>  >> > about
>> > 6
>> >> > months ago (the  mucuna has been a very recent thing, so it's been
> too
>> >  early
>> >> > to tell – but so far, I'm definitely  impressed). My neuro
> practically
>> > lit
>> >> >  his own hair on fire when I told him, but he couldn't deny  the
> results
>> > of
>> >> > the GSH.
>>  >> >
>> >> > The goal is to be able to cut the  amantadine by 35 - 50% within 6
>> > months.
>> >>  > My view is the longer I stay away from starting the agonists,  the
>> > better.
>> >> >
>> >> >  Hope that helps.
>> >> >
>> >> >
>>  >> >
>> >> > Joh
>> >> >
>>  >> >
>> >>
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