I'm with you all the way John!

I think after a few years most of us read articles like this with a lot of
skepticism...

Nic 57/15

On Wed, Nov 4, 2009 at 7:07 PM, john thomas <[log in to unmask]> wrote:

> I don't wish to be super negative but one must stop and question all
> sources
> of  information and claims that supposedly occur related to  PD cures.
> This article falls down in the first paragraph in that its model is assume
> to be "simulated but asymptomatic Parkinson's disease ". I would argue what
> the hell that is supposed to mean before I went on and read the article. I
> don't wish to can what in effect appears to be great research but it
> appears
> to me that every research fund searching group tacks on an added "oh it
> will
> also cure Pd "clause.
> There are many either erroneous  or at least presumptuous remarks , that
> would require further techniques knowledge , before I can comment further
> but it just bugs me that every time  a researcher has a flash of
> inspiration
> it triggers such media related response.
> -----Original Message-----
>
> John thomas BAps MR
>
>
> From: Parkinson's Information Exchange Network
> [mailto:[log in to unmask]] On Behalf Of Nic Marais
> Sent: Tuesday, November 03, 2009 8:24 AM
> To: [log in to unmask]
> Subject: Researchers find brain cell transplants help repair neural damage
>
> A Swiss research team has found that using an animal's own brain cells
> (autologous transplant) to replace degenerated neurons in select brain
> areas
> of donor primates with simulated but asymptomatic Parkinson's disease and
> previously in a motor cortex lesion model, provides a degree of brain
> protection and may be useful in repairing brain lesions and restoring
> function.
> "We aimed at determining whether autografted cells derived from cortical
> grey matter, cultured for one month and re-implanted in the caudate nucleus
> of dopamine depleted primates, effectively survived and migrated," said Dr
> Jean-Francoise Brunet of the Cell Transplantation Centre of Excellence for
> Aging and Brain Repair who, along with colleagues, published their study in
> Cell Transplantation. "The autologous, re-implanted cells survived at an
> impressively high rate of 50 per cent for four months post-implantation."
>
> While the use of neural grafts to restore function after lesions or
> degeneration of the central nervous system has been widely reported, the
> objective of this study was to replace depleted neurons to a restricted
> brain area and to avoid both the ethical controversies accompanying foetal
> cell transplants as well as immune rejection.
>
> Researchers found that the cultured cells migrated, re-implanted into the
> right caudate nucleus, and migrated through the corpus callosum to the
> contralateral striatum. Most of the cells were found in the most dopamine
> depleted region of the caudate nucleus. This study replicated in primates
> the success the research team had previously reported using laboratory
> mice.
>
> According to the researchers, the cultured cells exhibited neural
> progenitor
> characteristics that could make them useful for brain repair.
>
> "Our results confirm that adult brain cells can be obtained, cryopreserved
> and kept in culture before being re-implanted in the donor where they
> survive in vivo for at least four months," concluded Dr Brunet and
> colleagues. The study has drawn considerable interest in the
> transplantation
> community. "This is an extremely important finding because although we have
> known for many years that foetal cells can be used to replace damaged
> neurons their limited availability has prevented widespread use in clinical
> settings," commented Section Editor Dr John Sladek, professor of
> paediatrics
> and neuroscience at the University of Colorado School of Medicine.
>
>  http://www.popularmechanics.co.za/content/news/singlepage.asp?key=877
>
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