I found this interesting! Damn, ONLY $4 Billion!

"In 2015, the company's hepatitis C treatment sales peaked at $12.5 billion. 

treatments will bring in less than $4 billion this year."

John, caregiver for Sue 5/13/2016, RIP




-----Original Message-----
>From: Trauti Boyd <[log in to unmask]>
>Sent: Apr 20, 2018 4:10 AM
>To: [log in to unmask]
>Subject: Re: Nuplazid
>
>hi, ray! you must have missed goldman sachs' recent analysis of a 
>'one-shot cure' :
>
>/Analyst Salveen Richter and colleagues laid it out: "The potential to 
>deliver 'one shot cures' is one of the most attractive aspects of gene 
>therapy, genetically engineered cell therapy, and gene editing. However, 
>such treatments offer a very different outlook with regard to recurring 
>revenue versus chronic therapies... While this proposition carries 
>tremendous value for patients and society, it could represent a 
>challenge for genome medicine developers looking for sustained cash flow."
>
>For a real-world example, they pointed to Gilead Sciences, which markets 
>treatments for hepatitis C that have cure rates exceeding 90 percent. In 
>2015, the company's hepatitis C treatment sales peaked at $12.5 billion. 
>But as more people were cured and there were fewer infected individuals 
>to spread the disease, sales began to languish. Goldman Sachs analysts 
>estimate that the treatments will bring in less than $4 billion this 
>year. [Gilead]'s rapid rise and fall of its hepatitis C franchise 
>highlights one of the dynamics of an effective drug that permanently 
>cures a disease, resulting in a gradual exhaustion of the prevalent pool 
>of patients," the analysts wrote. The report noted that diseases such as 
>common cancers -- where the "incident pool remains stable" -- are less 
>risky for business./
>
>
>On 4/19/2018 11:02 PM, Rayilyn Brown wrote:
>> Hi Trauti,
>>
>> I guess I have a negative feeling re all these PD meds. I've taken  
>> Rytary and  Rimantadine for over a year  now without trouble but no 
>> real help either.   Wonder how  the Tasigna trials are going.  The 
>> powers that be have a big  nerve preventing its approval for PD when 
>> so many approved PD meds have such dreadful side  effects.  Amantadine 
>> helped for about a  month before all hell broke lose.  I'm betting on 
>> the Rytary rather than PD progression because these are such powerful 
>> drugs.
>>
>> I not only hate  getting worse but I can't fight so much anymore.
>>
>> -----Original Message----- From: Trauti Boyd
>> Sent: Wednesday, April 18, 2018 4:12 AM
>> To: [log in to unmask]
>> Subject: Re: Nuplazid
>>
>> hi, ray! i'm not sure if amantedine is responsible for nic's
>> hallucinations or a progression of pd. my husband is getting them more
>> and more these days and the only pd medicine he takes are 2 rytary
>> 61/245 per day. naturally, i have no way of knowing if the
>> levodopa/carbidopa might be the cause of this.
>>
>> and yes - it's a hateful disease with no improvements in sight! :(
>>
>>
>> On 4/18/2018 12:26 AM, Rayilyn Brown wrote:
>>> how I hate this disease!  do you get ANY good from these meds?
>>>
>>> -----Original Message----- From: Nic Marais
>>> Sent: Monday, April 16, 2018 4:21 PM
>>> To: [log in to unmask]
>>> Subject: Re: Nuplazid
>>>
>>> Ray
>>>
>>> Any spot on the wall grows legs and start moving...  :-)
>>>
>>> Visual hals are worse when I take my glasses off.
>>>
>>> I think what causes the hals is the brain trying to make sense out of 
>>> the
>>> noise (Of running bathwater, flushing toilet, unfocused spots, dark room
>>> with lots of shadows). Somehow Amantedine triggers this reaction.
>>>
>>> Something completely different;
>>>
>>> When I sit or stand in one position, I progressesively lean over to the
>>> left. It's very suttle and drives my wife bonckers. Reading a book, I 
>>> catch
>>> myself hanging on the table with my left hand, my head at an angle of
>>> about 45 degrees to the book. The other night I actually fell out of the
>>> chair... I suspect it is my lefthand back muscles. My left is more shaky
>>> than my right.
>>>
>>> Regards
>>>
>>> Nic
>>>
>>> On Sat, Apr 14, 2018, 08:00 Rayilyn Brown <[log in to unmask]> wrote:
>>>
>>>> Nic
>>>>
>>>> Now I know what those conversations I hear in  living room are. And I'm
>>>> getting hard of hearing.
>>>>
>>>> After a month Amantadine really did I number on me, not so nice.  
>>>> Besides
>>>> animals, monsters and dead people a thin saran-like substance was 
>>>> all over
>>>> everything!  my neuro said this substance was the most common 
>>>> Amantadine
>>>> hallucination.  and it helped me but I had to quit it, couldn't 
>>>> stand the
>>>> hals.  Have taken Rimantadine for over a year and except for one day 
>>>> when
>>>> I
>>>> thought I was seeing s mall black insects ive ben OK except it doesn't
>>>> help
>>>> much.  nothing does
>>>>
>>>> -----Original Message-----
>>>> From: Nic Marais
>>>> Sent: Tuesday, April 10, 2018 5:20 PM
>>>> To: [log in to unmask]
>>>> Subject: Re: Nuplazid
>>>>
>>>> I guess I have to get used to all the animals and people in the 
>>>> house. They
>>>> hide behind the bedroom curtains occasionally slipping a hand out   and
>>>> wave at me.
>>>>
>>>> They also sit on my bed and turn into big rats   running on my bed 
>>>> cover.
>>>> This is only the visual hals. The sound ones are the most difficult to
>>>> judge if it's reality or a hal... I don't mind the music when I 
>>>> flush the
>>>> toilet or run the bathWater. It's rather pleasant ;-) It's the 
>>>> whispers and
>>>> conversations and loud bangs that is very disturbing at times'
>>>>
>>>> Anybody like to share their hals on the list? Should be interesting ;-)
>>>>
>>>> Nic 66/24
>>>>
>>>>
>>>> On Apr 10, 2018 8:08 AM, "Rayilyn Brown" <[log in to unmask]> wrote:
>>>>
>>>> yes, I saw this too
>>>>
>>>>
>>>> -----Original Message-----
>>>> From: Maryse Schild
>>>> Sent: Monday, April 09, 2018 10:35 AM
>>>> To: [log in to unmask]
>>>> Subject: Nuplazid
>>>>
>>>> beware:
>>>>
>>>>
>>>> https://edition.cnn.com/2018/04/09/health/parkinsons-drug-nuplazid-invs/index.html 
>>>>
>>>>
>>>> maryse
>>>>
>>>> ----------------------------------------------------------------------
>>>> To sign-off Parkinsn send a message to: mailto:
>>>> [log in to unmask]
>>>> In the body of the message put: signoff parkinsn
>>>>
>>>> ----------------------------------------------------------------------
>>>> To sign-off Parkinsn send a message to: mailto:
>>>> [log in to unmask]
>>>> In the body of the message put: signoff parkinsn
>>>>
>>>> ----------------------------------------------------------------------
>>>> To sign-off Parkinsn send a message to: mailto:
>>>> [log in to unmask]
>>>> In the body of the message put: signoff parkinsn
>>>>
>>>> ----------------------------------------------------------------------
>>>> To sign-off Parkinsn send a message to: mailto:
>>>> [log in to unmask]
>>>> In the body of the message put: signoff parkinsn
>>>>
>>>
>>> ----------------------------------------------------------------------
>>> To sign-off Parkinsn send a message to: 
>>> mailto:[log in to unmask]
>>> In the body of the message put: signoff parkinsn
>>> ----------------------------------------------------------------------
>>> To sign-off Parkinsn send a message to: 
>>> mailto:[log in to unmask]
>>> In the body of the message put: signoff parkinsn
>>>
>>
>> ----------------------------------------------------------------------
>> To sign-off Parkinsn send a message to: 
>> mailto:[log in to unmask]
>> In the body of the message put: signoff parkinsn
>> ----------------------------------------------------------------------
>> To sign-off Parkinsn send a message to: 
>> mailto:[log in to unmask]
>> In the body of the message put: signoff parkinsn
>>
>
>
>----------------------------------------------------------------------
>To sign-off Parkinsn send a message to: mailto:[log in to unmask]
>In the body of the message put: signoff parkinsn

----------------------------------------------------------------------
To sign-off Parkinsn send a message to: mailto:[log in to unmask]
In the body of the message put: signoff parkinsn