This is exasperating..!

It underlines what we've been saying all along; That a cure is not in the
interest of the big pharmos...

Nic

On Sat, Apr 21, 2018, 08:00 Trauti Boyd <[log in to unmask]> wrote:

> hi, ray! you must have missed goldman sachs' recent analysis of a
> 'one-shot cure' :
>
> /Analyst Salveen Richter and colleagues laid it out: "The potential to
> deliver 'one shot cures' is one of the most attractive aspects of gene
> therapy, genetically engineered cell therapy, and gene editing. However,
> such treatments offer a very different outlook with regard to recurring
> revenue versus chronic therapies... While this proposition carries
> tremendous value for patients and society, it could represent a
> challenge for genome medicine developers looking for sustained cash flow."
>
> For a real-world example, they pointed to Gilead Sciences, which markets
> treatments for hepatitis C that have cure rates exceeding 90 percent. In
> 2015, the company's hepatitis C treatment sales peaked at $12.5 billion.
> But as more people were cured and there were fewer infected individuals
> to spread the disease, sales began to languish. Goldman Sachs analysts
> estimate that the treatments will bring in less than $4 billion this
> year. [Gilead]'s rapid rise and fall of its hepatitis C franchise
> highlights one of the dynamics of an effective drug that permanently
> cures a disease, resulting in a gradual exhaustion of the prevalent pool
> of patients," the analysts wrote. The report noted that diseases such as
> common cancers -- where the "incident pool remains stable" -- are less
> risky for business./
>
>
> On 4/19/2018 11:02 PM, Rayilyn Brown wrote:
> > Hi Trauti,
> >
> > I guess I have a negative feeling re all these PD meds. I've taken
> > Rytary and  Rimantadine for over a year  now without trouble but no
> > real help either.   Wonder how  the Tasigna trials are going.  The
> > powers that be have a big  nerve preventing its approval for PD when
> > so many approved PD meds have such dreadful side  effects.  Amantadine
> > helped for about a  month before all hell broke lose.  I'm betting on
> > the Rytary rather than PD progression because these are such powerful
> > drugs.
> >
> > I not only hate  getting worse but I can't fight so much anymore.
> >
> > -----Original Message----- From: Trauti Boyd
> > Sent: Wednesday, April 18, 2018 4:12 AM
> > To: [log in to unmask]
> > Subject: Re: Nuplazid
> >
> > hi, ray! i'm not sure if amantedine is responsible for nic's
> > hallucinations or a progression of pd. my husband is getting them more
> > and more these days and the only pd medicine he takes are 2 rytary
> > 61/245 per day. naturally, i have no way of knowing if the
> > levodopa/carbidopa might be the cause of this.
> >
> > and yes - it's a hateful disease with no improvements in sight! :(
> >
> >
> > On 4/18/2018 12:26 AM, Rayilyn Brown wrote:
> >> how I hate this disease!  do you get ANY good from these meds?
> >>
> >> -----Original Message----- From: Nic Marais
> >> Sent: Monday, April 16, 2018 4:21 PM
> >> To: [log in to unmask]
> >> Subject: Re: Nuplazid
> >>
> >> Ray
> >>
> >> Any spot on the wall grows legs and start moving...  :-)
> >>
> >> Visual hals are worse when I take my glasses off.
> >>
> >> I think what causes the hals is the brain trying to make sense out of
> >> the
> >> noise (Of running bathwater, flushing toilet, unfocused spots, dark room
> >> with lots of shadows). Somehow Amantedine triggers this reaction.
> >>
> >> Something completely different;
> >>
> >> When I sit or stand in one position, I progressesively lean over to the
> >> left. It's very suttle and drives my wife bonckers. Reading a book, I
> >> catch
> >> myself hanging on the table with my left hand, my head at an angle of
> >> about 45 degrees to the book. The other night I actually fell out of the
> >> chair... I suspect it is my lefthand back muscles. My left is more shaky
> >> than my right.
> >>
> >> Regards
> >>
> >> Nic
> >>
> >> On Sat, Apr 14, 2018, 08:00 Rayilyn Brown <[log in to unmask]> wrote:
> >>
> >>> Nic
> >>>
> >>> Now I know what those conversations I hear in  living room are. And I'm
> >>> getting hard of hearing.
> >>>
> >>> After a month Amantadine really did I number on me, not so nice.
> >>> Besides
> >>> animals, monsters and dead people a thin saran-like substance was
> >>> all over
> >>> everything!  my neuro said this substance was the most common
> >>> Amantadine
> >>> hallucination.  and it helped me but I had to quit it, couldn't
> >>> stand the
> >>> hals.  Have taken Rimantadine for over a year and except for one day
> >>> when
> >>> I
> >>> thought I was seeing s mall black insects ive ben OK except it doesn't
> >>> help
> >>> much.  nothing does
> >>>
> >>> -----Original Message-----
> >>> From: Nic Marais
> >>> Sent: Tuesday, April 10, 2018 5:20 PM
> >>> To: [log in to unmask]
> >>> Subject: Re: Nuplazid
> >>>
> >>> I guess I have to get used to all the animals and people in the
> >>> house. They
> >>> hide behind the bedroom curtains occasionally slipping a hand out   and
> >>> wave at me.
> >>>
> >>> They also sit on my bed and turn into big rats   running on my bed
> >>> cover.
> >>> This is only the visual hals. The sound ones are the most difficult to
> >>> judge if it's reality or a hal... I don't mind the music when I
> >>> flush the
> >>> toilet or run the bathWater. It's rather pleasant ;-) It's the
> >>> whispers and
> >>> conversations and loud bangs that is very disturbing at times'
> >>>
> >>> Anybody like to share their hals on the list? Should be interesting ;-)
> >>>
> >>> Nic 66/24
> >>>
> >>>
> >>> On Apr 10, 2018 8:08 AM, "Rayilyn Brown" <[log in to unmask]> wrote:
> >>>
> >>> yes, I saw this too
> >>>
> >>>
> >>> -----Original Message-----
> >>> From: Maryse Schild
> >>> Sent: Monday, April 09, 2018 10:35 AM
> >>> To: [log in to unmask]
> >>> Subject: Nuplazid
> >>>
> >>> beware:
> >>>
> >>>
> >>>
> https://edition.cnn.com/2018/04/09/health/parkinsons-drug-nuplazid-invs/index.html
> >>>
> >>>
> >>> maryse
> >>>
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