Part Two of MEDLINE on PD and childhood diseases, influenza, and
environmental exposures.
 
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07524547 91043547
  Hemiparkinsonism-hemiatrophy syndrome: clinical and
neuroradiologic
features.
  Giladi N; Burke RE; Kostic V; Przedborski S; Gordon M; Hunt A; Fahn S
  Neurological Institute, College of Physicians and Surgeons of
Columbia
University, New York, NY.
  Neurology (UNITED STATES) Nov 1990, 40 (11) p1731-4, ISSN
0028-3878
Journal Code: NZ0
  Contract/Grant No.: R-29 NS26836, NS, NINDS
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9102
  Subfile: AIM; INDEX MEDICUS
  We evaluated 11 patients with hemiparkinson-hemiatrophy syndrome, 6
with
body and contralateral cerebral hemispheric hemiatrophy, 4 with only
body
hemiatrophy, and 1 with just brain hemiatrophy. The mean age of
symptom
onset was 38.1 years (range, 18 to 54) with 5.2 +/- 3.1 (mean +/- SD)
years
of illness until the last follow-up visit. The presenting symptom
was
unilateral tremor in 6 patients, hand dystonia in 2, bradykinesia in 2,
and
abnormal gait in 1 patient. Three patients had a good response to
levodopa,
4 had moderate response, and 2 patients had a poor response. During a
mean
follow-up period of 1.7 years (range, 4 months to 5 years), the Hoehn
and
Yahr score changed in only 3 patients: 2 gained 1.5 points and 1
gained 3
points over 2.5 years. We discuss the association
between
hemiparkinsonism-body hemiatrophy and contralateral
hemispheric
hemiatrophy, and raise the possibility of early childhood brain insult
with
delayed-onset parkinsonism.
  Tags: Female; Human; Male; Support, Non-U.S. Gov't; Support, U.S.
Gov't,
Non-P.H.S.; Support, U.S. Gov't, P.H.S.
  Descriptors: *Brain--Pathology--PA;
*Extremities--Pathology--PA;
*Parkinson Disease, Symptomatic--Diagnosis--DI; Adolescence; Adult;
Atrophy
; Brain--Radiography--RA; Follow-Up Studies; Levodopa--Therapeutic
Use--TU;
Magnetic Resonance Imaging; Middle Age; Parkinson Disease,
Symptomatic
--Drug Therapy--DT; Parkinson Disease,
Symptomatic--Radiography--RA;
Retrospective Studies; Syndrome; Tomography, X-Ray Computed
  CAS Registry No.: 0 (Levodopa)
 
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06407280 88052280
  Environmental factors in the etiology of Parkinson's disease.
  Tanner CM; Chen B; Wang WZ; Peng ML; Liu ZL; Liang XL; Kao LC; Gilley
DW;
Schoenberg BS
  Department of Neurological Sciences, Rush-Presbyterian-St. Luke's
Medical
Center, Chicago, IL.
  Can J Neurol Sci (CANADA) Aug 1987, 14 (3 Suppl) p419-23,
ISSN
0317-1671 Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
  JOURNAL ANNOUNCEMENT: 8803
  Subfile: INDEX MEDICUS
  Parkinson's disease (PD) has been proposed to result from the
interaction
of aging and environment in susceptible individuals. Defective
metabolism
of debrisoquine, inherited as an autosomal recessive, has been
associated
with this susceptibility. In 35 PD patients and 19 age-matched controls,
no
significant differences in debrisoquine metabolism were found,
although a
trend to impaired metabolism was noted in patients with disease onset
less
than or equal to 40. Foci of PD patients were associated with rural
living
and well water drinking, or rural living coupled with market gardening
or
wood pulp mills. In a questionnaire survey, patients with PD onset
less
than or equal to age 47 were significantly more likely to have lived
in
rural areas and to have drunk well water than those with onset greater
than
or equal to age 54 (p less than or equal to 0.01). Because of
population
mobility in North America, a case-control study designed to
test
environmental, occupational, dietary and other proposed risk factors for
PD
was conducted in China, where the population is more stationary and
the
environment more stable. No significant differences in incidences of
head
trauma, smoking or childhood measles were found between patients
and
controls. (47 Refs.)
  Tags: Female; Human; Male; Support, Non-U.S. Gov't
  Descriptors: *Environment; *Parkinson Disease,
Symptomatic--Etiology--ET
; Adult; Environmental Pollution--Adverse Effects--AE; Middle
Age;
Parkinson Disease, Symptomatic--Chemically Induced--CI; Parkinson
Disease,
Symptomatic--Genetics--GE; Rural Population; Smoking--Adverse
Effects--AE;
Stress--Complications--CO
 
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06407279 88052279
  Geography, drinking water chemistry, pesticides and herbicides and
the
etiology of Parkinson's disease.
  Rajput AH; Uitti RJ; Stern W; Laverty W; O'Donnell K; O'Donnell D;
Yuen
WK; Dua A
  Department of Clinical Neurological Sciences, University
Hospital,
Saskatoon, Saskatchewan, Canada.
  Can J Neurol Sci (CANADA) Aug 1987, 14 (3 Suppl) p414-8,
ISSN
0317-1671 Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8803
  Subfile: INDEX MEDICUS
  In 1984 we made the first observation of a correlation between early
age
exposure to rural environment (and drinking well water) and development
of
idiopathic Parkinson's disease (IPD). These findings were
subsequently
confirmed elsewhere (Barbeau, 1985;25 Tanner, 1985). Analysis of all
early
age onset IPD (EPD) cases born and raised in Saskatchewan revealed that
20
of 22 had exclusively rural exposure during the first 15 years of
life.
This distribution was significantly different from the general
population
(p = 0.0141). Further study of the EPD group included sampling and
metal
analysis of childhood sources of drinking water in 18 cases and 36 age
and
sex-matched controls. Water collected from the two groups was analyzed
for
23 metals (including 7 elements implicated in the etiology of IPD).
There
was no difference in the metal composition of the water between the
two
groups. Finally, a review of herbicide and pesticide use in
Saskatchewan
agriculture was undertaken to determine if there was an increased
incidence
of EPD following utilization of any particular chemical. No increase
was
found in the incidence of EPD with the introduction of any pesticide
or
herbicide, including Paraquat, for agricultural use. We conclude that
there
is a strong correlation between early age rural environmental exposure
and
development of IPD. We believe well water is a likely vehicle for
the
causal agent, but neither water metal concentration nor any of
the
herbicides and pesticides used in Saskatchewan agriculture are related
to
the cause.
  Tags: Human
  Descriptors: *Environmental Pollution--Adverse Effects--AE;
*Herbicides
--Adverse Effects--AE; *Parkinson Disease, Symptomatic--Chemically
Induced
--CI; *Pesticides--Adverse Effects--AE; *Water Pollution,
Chemical--Adverse
Effects--AE; Adult; Canada; Middle Age; Parkinson Disease,
Symptomatic
--Epidemiology--EP; Parkinson Disease, Symptomatic--Etiology--ET
  CAS Registry No.: 0 (Herbicides); 0 (Pesticides)
 
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06178651 87152651
  Early onset Parkinson's disease and childhood environment.
  Rajput AH; Uitti RJ; Stern W; Laverty W
  Adv Neurol (UNITED STATES) 1987, 45 p295-7, ISSN 0091-3952
Journal Code: 2NX
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8706
  Subfile: INDEX MEDICUS
  Tags: Human; Support, Non-U.S. Gov't
  Descriptors: *Parkinson Disease--Etiology--ET; *Social Environment;
Adult
; Aged; Follow-Up Studies; Middle Age; Risk; Rural Population;
Saskatchewan
; Urban Population
 
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06077110 87051110
  Early onset Parkinson's disease in
Saskatchewan--environmental
considerations for etiology.
  Rajput AH; Uitti RJ; Stern W; Laverty W
  Can J Neurol Sci (CANADA) Nov 1986, 13 (4) p312-6, ISSN 0317-1671
Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8703
  Subfile: INDEX MEDICUS
  The cause of idiopathic Parkinson's Disease (PD) is not known but it
is
believed to be related to some environmental agent(s). Given a
long
preclinical interval and onset of symptomatology around age 60 years,
it
becomes impossible to identify and analyze all prior environmental
factors
satisfactorily. To circumvent these difficulties we evaluated the
childhood
environment in those PD patients whose symptoms began at age 40 years
or
earlier. Twenty-one such cases were born and raised in the province
of
Saskatchewan. Nineteen of these 21 patients spent the first 15 years
of
life exclusively in rural Saskatchewan. Detailed population
analysis
indicates a strong predisposition to early onset idiopathic
Parkinson's
Disease (EPD) in those raised in rural areas (p = 0.0154). All but one
case
utilized exclusively well water for the first 15 years of life--a
trait
significantly different from that expected in the provincial population.
It
is concluded that rural Saskatchewan environments contribute to EPD
and
that well water used in childhood should be considered as a
potential
vehicle for the etiological agent.
  Tags: Human; Support, Non-U.S. Gov't
  Descriptors: *Parkinson Disease--Etiology--ET; *Water Supply; Age
Factors
; Environment; Parkinson Disease--Epidemiology--EP; Retrospective
Studies;
Rural Population; Saskatchewan; Urban Population
 
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05746779 86047779
  Measles infection and Parkinson's disease.
  Sasco AJ; Paffenbarger RS Jr
  Am J Epidemiol (UNITED STATES) Dec 1985, 122 (6) p1017-31,
ISSN
0002-9262 Journal Code: 3H3
  Contract/Grant No.: CA 25264
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8602
  Subfile: INDEX MEDICUS
  A case-control analysis of Parkinson's disease and infections
 in
childhood was conducted in a cohort of 50,002 men who attended
Harvard
College (Cambridge, MA) or the University of Pennsylvania
(Philadelphia,
PA) between 1916 and 1950 and who were followed in adulthood for
morbidity
and mortality data. Cases of Parkinson's disease were identified
from
responses to mailed questionnaires and death certificates through
1978.
Four controls from the same population were selected for each
case. A
reduced risk of Parkinson's disease was associated with most
childhood
viral infections. The negative association was statistically
significant
for a history of measles prior to college entrance (exposure odds
ratio =
0.53; 95% confidence limits: 0.31, 0.93). The reduced risk of
Parkinson's
disease among subjects with a positive history of measles in childhood
may
reflect an adverse effect of measles in adulthood or of subclinical
or
atypical measles. Furthermore, a negative history of measles, especially
if
associated with a lack of other common diseases, could be a marker
for
negative influenza history before 1918 and thus a higher risk of
infection
during the 1918 influenza epidemic, because of the lack of
partial
influenza immunity. These data may also suggest a truly protective
effect
of measles, compatible with some complex interaction between measles
virus
and the virus of the 1918 influenza epidemic.
  Tags: Human; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
  Descriptors: *Measles--Complications--CO; *Parkinson
Disease--Etiology
--ET; Adolescence; Adult; Aged; Child; Child, Preschool; Death
Certificates
; Epidemiologic Methods; Infant; Influenza--Complications--CO;
Longitudinal
Studies; Massachusetts; Measles--Epidemiology--EP; Middle Age;
Parkinson
Disease--Epidemiology--EP; Parkinson Disease--Mortality--MO;
Pennsylvania;
Questionnaires; Regression Analysis; Risk
 
_======================================================================
 
Hopes this is helpful.
 
Best,
 
Bob
 
--
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Robert A. Fink, M. D., F.A.C.S. Phone: 510-849-2555
Neurological Surgery FAX: 510-849-2557
2500 Milvia Street Suite 222
Berkeley, California 94704-2636
USA
 
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