Anne:  Here follows a MEDLINE search of the literature on treatment of
intractable hiccups.  The last articles (both the same) deal
specifically with the treatment of hiccups in Parkinson's Disease, and
the drug of choice appears to be Metoclopramide (Reglan).  Hope this is
helpful.
 
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08999191   94314191
  Neuroleptic  drug use in nonpsychiatric departments of a Dutch
university
hospital.
  Zitman FG; Pennings TM; Raes DC; Hekster YA
  Department of Psychiatry, University Hospital Nijmegen, The
Netherlands.
  Gen  Hosp  Psychiatry (UNITED  STATES)   Jan  1994,  16  (1)
p32-7,  ISSN
0163-8343   Journal Code: FNK
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9410
  Subfile:   INDEX MEDICUS
  During  a  1-year  period,  neuroleptic  drug utilization was
assessed in
nonpsychiatric  departments of a Dutch university hospital in
defined daily
doses  (DDD),  DDD  per  100  patients  and  per  100 bed days.
Substantial
divergence  was  found among the nonpsychiatric departments with
respect to
the  quantity  as  well  as the types of neuroleptic used, but
there was no
relationship  between  psychiatric  consultations  and
neuroleptic use. In
semistructured  interviews, the senior consultant at each
department stated
that  neuroleptics  were  used  not  only  for  the  treatment
of behavior
disorders  but  also  for nonpsychiatric indications, such as
pain, nausea,
and  hiccups.  In  addition,  specific  neuroleptics  were
considered to be
appropriate  for  the  treatment  of  specific  indications,  but
the doses
anticipated  to  be effective were in many cases well below the
DDDs. It is
concluded  that  substantial  quantities of neuroleptics are
prescribed for
nonpsychiatric  use. This is remarkable, because very little is
known about
nonpsychiatric  indications  and the effects of neuroleptics,
including the
unwanted side effects, in patients who are somatically ill.
  Tags: Comparative Study; Human
  Descriptors:  *Cross-Cultural Comparison; *Patient Care
Team--Statistical
and  Numerical  Data--SN;  *Prescriptions,  Drug--Statistical and
Numerical
Data--SN;   *Tranquilizing   Agents,   Major--Therapeutic
Use--TU;   Drug
Utilization--Trends--TD;  Hospitals,  University;
Netherlands--Epidemiology
--EP;    Specialties,    Medical--Statistical   and   Numerical
Data--SN;
Tranquilizing Agents, Major--Adverse Effects--AE
  CAS Registry No.: 0   (Tranquilizing Agents, Major)
 
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08910097   94225097
  [Chronic hiccups]
  Le hoquet chronique.
  Cabane  J; Desmet V; Derenne JP; Similowski T; Launois S; Bizec
JL; Orcel
B
  Service  de  Medecine  Interne  (Pr J. C. IMBERT), Hopital
Saint-Antoine,
Paris.
  Rev Med Interne (FRANCE)   Nov 1992,  13 (6) p454-9,  ISSN
0248-8663
Journal Code: SGJ
  Languages: FRENCH   Summary Languages: ENGLISH
  Document type: JOURNAL ARTICLE   English Abstract
  JOURNAL ANNOUNCEMENT: 9408
  Subfile:   INDEX MEDICUS
  We report 18 cases of chronic hiccup (defined as lasting for
more than 48
hours)  in  adults.  Among the numerous possible causes, reflux
esophagitis
proved  to  be by far the most frequent (50% of the cases).
However, hiccup
often  initiated  a  self-perpetuating  vicious  circle.  This
is possibly
because  hiccup  per se can give esophageal dyskinesia, which in
turn leads
to  gastro-esophageal  reflux.  The  treatment  was  difficult
and whenever
possible  has  been  directed  chiefly  towards  the  cause.
However hiccup
remained  intractable  in  many  cases even after a possible
cause had been
adequately  cured  (e.g.,  successful  Nissen  procedure  in
reflux cases).
Central  nervous  system  depressants  and  myorelaxing drugs
were not very
helpful, except for baclofen (initial response rate = 60%).
  Tags: Case Report; Female; Human; Male
  Descriptors:  *Hiccup--Epidemiology--EP;
*Hiccup--Etiology--ET;  Adult;
Aged;  Aged,  80  and over; Baclofen--Therapeutic Use--TU;
Chronic Disease;
Esophagitis,  Peptic--Complications--CO;  Esophagitis,
Peptic--Epidemiology
--EP;   Esophagitis,  Peptic--Surgery--SU;
Hiccup--Diagnosis--DI;   Hiccup
--Physiopathology--PP;    Hiccup--Therapy--TH;   Middle   Age;
Prospective
Studies; Remission, Spontaneous; Risk Factors; Treatment Outcome
  CAS Registry No.: 1134-47-0   (Baclofen)
 
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08755297   94070297
  Persistent postoperative hiccups: a review.
  Hansen BJ; Rosenberg J
  Department  of  Surgical  Gastroenterology, Hvidovre University
Hospital,
Denmark.
  Acta   Anaesthesiol  Scand (DENMARK)   Oct  1993,  37  (7)
p643-6,  ISSN
0001-5172   Journal Code: 08O
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
  JOURNAL ANNOUNCEMENT: 9403
  Subfile:   INDEX MEDICUS
  The  pathogenesis  of  persistent  postoperative  hiccups  is
not known.
Hiccups  can  present  as  a  symptom  of  a  subphrenic abscess
of gastric
distention,  and  metabolic alterations may also cause hiccups.
The hiccups
may develop because of increased activity in neural reflex
pathways not yet
fully  defined.  Numerous  treatment  modalities  have  been
tried but with
questionable   success.  Valproate  has  proven  effective  in
two  trials
investigating  persistent non-surgical hiccups. The simple
application of a
nasogastric tube may successfully treat the hiccups, possibly
because of an
alteration  of  the  activity  in  the reflex neural pathways
involved. The
available  literature  on  the treatment of persistent hiccups is
reviewed,
and a treatment protocol for persistent postoperative hiccups is
provided.
(24 Refs.)
  Tags: Human
  Descriptors: *Hiccup--Etiology--ET;  *Hiccup--Therapy--TH;
*Postoperative
Complications; Time Factors
 
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08514980   93224980
  Intractable  hiccups:  treatment  by  microvascular
decompression of the
vagus nerve. Case Report.
  Johnson DL
  Division  of  Neurosurgery,  Children's  Hospital,  Penn State
University
School   of   Medicine,   Milton   S.   Hershey  Medical  Center,
 Hershey,
Pennsylvania.
  J Neurosurg (UNITED STATES)   May 1993,  78 (5) p813-6,  ISSN
0022-3085
Journal Code: JD3
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9307
  Subfile:   AIM; INDEX MEDICUS
  Idiopathic  hiccups  are usually managed with pharyngeal
stimulation or a
plethora   of  pharmacological  agents.  Hiccups  that  persist
and  prove
intractable  to  these medical measures are treated by crush or
ablation of
the  phrenic  nerve, which denervates the major respiratory
muscle. This is
the  first  reported  case of nondestructive microvascular
decompression of
the  vagus  nerve  for the treatment of intractable idiopathic
hiccups. The
success  of  microvascular  decompression  has  been  documented
with other
conditions,  such  as  trigeminal  neuralgia and hemifacial
spasm, that are
characterized by hyperactive dysfunctional neurovascular contact.
The vagus
nerve  was  separated  from  the  posterior  inferior  cerebellar
artery by
inserting  a  Teflon  pledget between the nerve and vessel which
eliminated
the  neurovascular contact. One year after the initial surgery,
the hiccups
recurred. The Teflon pledget had fallen out of place and the
nerve was once
again  in  contact  with  the  artery.  Once  the contact was
eliminated by
wrapping the artery with a tuft of Teflon, the hiccups stopped.
The patient
has  remained  free  of  hiccups for 3 years. It is concluded
that patients
with  intractable  idiopathic  hiccups  who  fail medical therapy
should be
considered for microvascular decompression of the vagus nerve.
  Tags: Case Report; Female; Human
  Descriptors: *Hiccup--Surgery--SU; *Vagus Nerve--Surgery--SU;
Adolescence
;   Arteries--Abnormalities--AB;   Cerebellum--Blood
Supply--BS;   Hiccup
--Etiology--ET; Microsurgery
 
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08472961   93182961
  [Stopping persistent hiccups in the adult by endoscopic
maneuver]
  Arret du hoquet persistant de l'adulte par manoeuvres
endoscopiques.
  Beda BY; Niamkey EK; Ouattara D; Diallo AD; Adom AH; Djakoure
S; Yoboue L
; Yangni-Angate Y; Kadjo K; Toutou T; et al
  Service de medecine interne, CHU de Treichville, Abidjan
Cote-d'Ivoire.
  Ann Gastroenterol Hepatol (Paris) (FRANCE)   Jan-Feb 1993,  29
(1) p11-3,
ISSN 0066-2070   Journal Code: 55A
  Languages: FRENCH   Summary Languages: ENGLISH
  Document type: JOURNAL ARTICLE   English Abstract
  JOURNAL ANNOUNCEMENT: 9306
  Subfile:   INDEX MEDICUS
  Thirty-four  patients  with  persistent hiccups (median
duration 10 days)
were  treated  by  gentle  endoscopic  massage of the region of
the cardia.
Hiccups  stopped  in  all  cases.  Its early recurrence in one
patient only
required  a second massage, which was also effective. This simple
technique
is recommended for the treatment of persistent hiccups.
  Tags: Female; Human; Male
  Descriptors:  *Endoscopy, Gastrointestinal--Methods--MT;
*Hiccup--Therapy
--TH;  *Massage--Methods--MT;  Adolescence;  Adult;  Aged;
Chronic Disease;
Cote d'Ivoire--Epidemiology--EP; Endoscopy,
Gastrointestinal--Standards--ST
;    Hiccup--Epidemiology--EP;     Hiccup--Etiology--ET;
Hospitalization
--Statistical   and  Numerical  Data--SN;  Hospitals,
University;  Massage
--Standards--ST; Middle Age; Recurrence; Time Factors
 
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08290949   93000949
  Hiccups. A case presentation and etiologic review.
  Loft LM; Ward RF
  Department of Otolaryngology, Head, and Neck Surgery, Manhattan
Eye, Ear,
and Throat Hospital, New York, NY 10021.
  Arch  Otolaryngol  Head  Neck  Surg (UNITED STATES)   Oct 1992,
 118 (10)
p1115-9,  ISSN 0886-4470   Journal Code: ALQ
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
  JOURNAL ANNOUNCEMENT: 9301
  Subfile:   AIM; INDEX MEDICUS
  Hiccups  (singultus)  usually  present  as a common annoyance
lasting for
short  periods.  Rarely, they may be the harbinger of a serious
disease. We
present  the case of a 19-year-old man in which intractable
hiccups was the
first  and  most  prominent  symptom  of  a  serious  underlying
neurologic
disorder.  The  patient  had been examined by his pediatrician,
and despite
multiple  medical regiments and physical maneuvers, his symptoms
persisted.
A  thorough  head  and  neck  examination revealed a right-sided
vocal cord
paralysis.  This  finding  prompted  obtaining a magnetic
resonance imaging
scan,  which  demonstrated  a  type I Arnold-Chiari malformation
associated
with a large cervicothoracic syringomyelia. The patient was
referred to the
neurosurgical  service  and  subsequently  underwent a
ventriculoperitoneal
shunt   placement.  There  was  considerable  initial
improvement  in  his
neurologic  status  and  cessation  of  the  hiccups. However,
the symptoms
recurred  within  1 month. The case report as well as a brief
review of the
relevant   pathophysiologic   and   etiologic  considerations
and  several
treatment modalities for hiccups is presented.  (36 Refs.)
  Tags: Case Report; Human; Male
  Descriptors:     *Hiccup;     Adult;     Hiccup--Etiology--ET;
   Hiccup
--Physiopathology--PP;  Hiccup--Therapy--TH
 
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07984861   92122861
  High-frequency   diaphragmatic   flutter:   symptoms   and
treatment  by
carbamazepine.
  Vantrappen G; Decramer M; Harlet R
  Department of Medicine, University Hospital of Leuven, Belgium.
  Lancet (ENGLAND)   Feb 1 1992,  339 (8788) p265-7,  ISSN
0023-7507
Journal Code: L0S
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9204
  Subfile:   AIM; INDEX MEDICUS
  Classic  diaphragmatic flutter, a rare disorder associated with
dyspnoea,
thoracic  or  abdominal  wall pain, and epigastric pulsations, is
caused by
involuntary  contractions  of the diaphragm with a frequency of
0.5-8.0 Hz.
We  have seen three patients with diaphragmatic flutter of higher
frequency
not  associated  with  respiratory  disease.  The  patients
presented with
longstanding oesophageal belching, hiccups, and retching,
respectively. The
diagnosis  was  established  by  the  presence  on
electromyography of the
diaphragm  and  scalene  and  parasternal intercostal muscles of
repetitive
discharges of 9-15 Hz. Spirographic tracings, especially those of
volume or
flow  vs  time,  showed similar high-frequency oscillations
superimposed on
tidal  respiratory movements. Treatment with carbamazepine
200-400 mg three
times  daily  led  to  disappearance  or  great  improvement of
flutter and
clinical  symptoms  in  all  three patients. The phenomenon was
not seen in
other  patients with chronic hiccups or oesophageal belching or
in patients
without  these  symptoms  who had undergone electromyography or
spirography
for other reasons. Thus, high-frequency diaphragmatic flutter
seems to be a
new  disease entity. The response to carbamazepine, which
suggests that the
flutter causes the symptoms, requires further study.
  Tags: Case Report; Female; Human; Male
  Descriptors:  *Carbamazepine--Therapeutic  Use--TU; *Diaphragm;
*Muscular
Diseases--Drug  Therapy--DT; Adult; Aged;
Carbamazepine--Administration and
Dosage--AD;  Drug  Administration  Schedule;
Electromyography--Methods--MT;
Eructation--Drug   Therapy--DT;    Eructation--Etiology--ET;
Hiccup --Drug
Therapy--DT;   Hiccup--Etiology--ET;  Intestinal
Pseudo-Obstruction --Drug
Therapy--DT;    Intestinal  Pseudo-Obstruction--Etiology--ET;
Middle  Age;
Muscle  Contraction--Drug  Effects--DE;  Muscular
Diseases--Physiopathology
--PP
  CAS Registry No.: 298-46-4   (Carbamazepine)
 
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07805895   91324895
  Treatment of persistent hiccups [letter]
  Grant JA; Steiner EM; Johnson RH
  J  Neurol  Neurosurg Psychiatry (ENGLAND)   May 1991,  54 (5)
p468,  ISSN
0022-3050   Journal Code: JBB
  Languages: ENGLISH
  Document type: LETTER
  JOURNAL ANNOUNCEMENT: 9111
  Subfile:   INDEX MEDICUS
  Tags: Case Report; Human
  Descriptors:  *Baclofen--Therapeutic  Use--TU; *Hiccup--Drug
Therapy--DT;
Aged;  Baclofen--Administration and Dosage--AD; Dose-Response
Relationship,
Drug; Drug Administration Schedule; Middle Age
  CAS Registry No.: 1134-47-0   (Baclofen)
 
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07702346   91221346
  Hiccups (singultus): review and approach to management.
  Kolodzik PW; Eilers MA
  Department  of  Emergency  Medicine,  Wright  State  University
School of
Medicine, Dayton, Ohio 45401-0927.
  Ann   Emerg   Med (UNITED   STATES)   May  1991,  20  (5)
p565-73,  ISSN
0196-0644   Journal Code: 4Z7
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
  JOURNAL ANNOUNCEMENT: 9108
  Subfile:   AIM; INDEX MEDICUS
  Hiccups  are  a common, and fortunately usually transient,
benign malady.
Occasionally,  however, hiccups fail to resolve spontaneously,
resulting in
patient fatigue and incapacitation and the need for the affected
individual
to  seek  medical  care  for resolution of the problem. The
approach to the
management  of  these patients consists of the identification and
treatment
of  serious  underlying  causes  of  the  episode  as  well  as
therapeutic
interventions to achieve hiccup resolution.  (113 Refs.)
  Tags: Female; Human; Male
  Descriptors: *Hiccup; Hiccup--Physiopathology--PP;
Hiccup--Therapy--TH
 
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07248363   90155363
  Persistent periodic hiccups following brain abscess: a case
report.
  Jansen PH; Joosten EM; Vingerhoets HM
  Institute  of  Neurology,  St  Radboud  Hospital,  Catholic
University of
Nijmegen, Nijmegen, The Netherlands.
  J  Neurol Neurosurg Psychiatry (ENGLAND)   Jan 1990,  53 (1)
p83-4,  ISSN
0022-3050   Journal Code: JBB
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9005
  Subfile:   INDEX MEDICUS
  A  case  is  reported  of  a patient with periodic persistent
hiccups and
secondary generalised epilepsy lasting for a period of five years
following
a right temporal brain abscess. The recurring episodes of hiccups
had a ten
day  rhythmicity  and  unlike  epileptic  convulsions  were
unresponsive to
treatment.
  Tags: Case Report; Human; Male
  Descriptors:  *Brain  Abscess--Complications--CO;
*Hiccup--Etiology--ET;
*Meningitis,    Pneumococcal--Complications--CO;   Adult;   Brain
  Abscess
--Diagnosis--DI; Brain Concussion--Complications--CO;
Electroencephalograph
y;  Follow-Up  Studies;  Frontal  Lobe--Pathology--PA;  Magnetic
Resonance
Imaging;   Meningitis,   Pneumococcal--Diagnosis--DI;
Recurrence;   Skull
Fractures--Complications--CO; Temporal Lobe--Pathology--PA
 
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07106676   90013676
  Possible  role  of  autonomic  afferents  in  treatment  of
postoperative
hiccups [letter]
  Rosenberg J; Hansen B
  Lancet (ENGLAND)   Oct 7 1989,  2 (8667) p873,  ISSN 0023-7507
Journal Code: L0S
  Languages: ENGLISH
  Document type: LETTER
  JOURNAL ANNOUNCEMENT: 9001
  Subfile:   AIM; INDEX MEDICUS
  Tags: Case Report; Human; Male
  Descriptors:  *Afferent Pathways--Physiopathology--PP;
*Autonomic Nervous
System--Physiopathology--PP; *Cholecystectomy--Adverse
Effects--AE; *Hiccup
--Therapy--TH;      Adult;     Hiccup--Physiopathology--PP;
Intubation,
Gastrointestinal
 
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06974592   89276592
  Interactional treatment of intractable hiccups.
  Bobele M
  Department  of  Human  Development  and  Family  Studies,
College of Home
Economics, Texas Tech University, Lubbock 79409.
  Fam Process (UNITED STATES)   Jun 1989,  28 (2) p191-206,  ISSN
0014-7370
Journal Code: ESA
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8909
  Subfile:   INDEX MEDICUS
  This  article provides a comprehensive review of the literature
regarding
nonmedical  approaches  to  the  understanding and treatment of
intractable
hiccups.  The  author  provides  a  rationale for an
interactional view and
presents  a  case in which post-surgical hiccups were
successfully treated,
using  principles developed by the Mental Research Institute. Of
particular
interest  is  the  manner  in  which  the  therapist  managed a
system that
included  the  victim's  wife, a physician, and other medical
personnel who
were  all  trying  to  eliminate  the  hiccups. Interventions
were designed
primarily  to  alter  meanings  attributed  to  the  hiccups
and, thus, to
intervene  in  the system that was maintaining the problem. This
article is
presented  as  a  response  to Weakland's call for research and
practice in
family somatics.
  Tags: Case Report; Human; Male
  Descriptors:   *Conversion   Disorder--Psychology--PX;  *Family
 Therapy;
*Hiccup--Psychology--PX;  Adult;  Conversion
Disorder--Therapy--TH; Family;
Hiccup--Therapy--TH
 
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06071756   87045756
  Chronic hiccups.
  Lipsky MS
  Am   Fam  Physician (UNITED  STATES)   Nov  1986,  34  (5)
p173-7,  ISSN
0002-838X   Journal Code: 3BT
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8702
  Subfile:   AIM; INDEX MEDICUS
  Patients  with  chronic  hiccups  should  be  carefully
examined  for an
underlying   disorder  while  receiving  symptomatic  treatment.
Treatment
includes  physical maneuvers, drugs such as chlorpromazine,
metoclopramide,
anticonvulsants  or  quinidine,  and  other, less tested
modalities such as
hypnosis. Only those patients with disabling hiccups that do not
respond to
conservative treatment should be considered for phrenic nerve
surgery.
  Tags: Case Report; Female; Human; Male
  Descriptors:  *Hiccup--Etiology--ET;  Adult;
Anticonvulsants--Therapeutic
Use--TU;   Central   Nervous  System
Diseases--Complications--CO;  Chronic
Disease;  Diabetes  Mellitus--Complications--CO;  Hiccup--Drug
Therapy--DT;
Peripheral   Nervous   System  Diseases--Complications--CO;
Valproic  Acid
--Therapeutic Use--TU
  CAS Registry No.: 0   (Anticonvulsants); 99-66-1   (Valproic
Acid)
 
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05747279   86048279
  Treatment of intractable hiccups with intramuscular
haloperidol.
  Ives TJ; Fleming MF; Weart CW; Bloch D
  Am  J  Psychiatry (UNITED  STATES)   Nov  1985,  142  (11)
p1368-9,  ISSN
0002-953X   Journal Code: 3VG
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8602
  Subfile:   AIM; INDEX MEDICUS
  Two  patients  with  intractable  hiccups were treated with
intramuscular
haloperidol;  remission  occurred  within 1 hour. With its rapid
action and
low  incidence  of  adverse  effects,  intramuscular  haloperidol
should be
considered  a  therapeutic  alternative  in  the  treatment  of
intractable
hiccups.
  Tags: Case Report; Human; Male
  Descriptors:  *Haloperidol--Administration  and Dosage--AD;
*Hiccup--Drug
Therapy--DT;  Adult;  Aged;  Haloperidol--Adverse  Effects--AE;
Injections,
Intramuscular
  CAS Registry No.: 52-86-8   (Haloperidol)
 
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DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
05728979   86029979
  Potential uses for metoclopramide.
  Shaughnessy AF
  Drug Intell Clin Pharm (UNITED STATES)   Oct 1985,  19 (10)
p723-8,
ISSN 0012-6578   Journal Code: EBU
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW
  JOURNAL ANNOUNCEMENT: 8602
  Subfile:   INDEX MEDICUS
  Metoclopramide,  a  dopamine  antagonist, is approved in the
U.S. for the
treatment   of   various  gastrointestinal  disorders.  Its  use
has  been
investigated  in  a wide variety of diseases, including those not
involving
the  intestinal  tract.  Although  more  study  is  required
before routine
clinical use of metoclopramide can be advocated, it may be
effective in the
treatment  of tardive dyskinesia, in decreasing the risk factors
associated
with  anesthetic-related  aspiration, and as an adjunct in the
treatment of
gastric  bezoars.  It  also may be used safely in patients with
Parkinson's
disease.  The use of metoclopramide in the treatment of
neurogenic bladder,
orthostatic  hypotension,  tumor-associated gastroparesis,
nonprolactinemic
amenorrhea,  failure  to thrive, Tourette's syndrome, anorexia
nervosa, and
hiccups,  as well as an adjunct to migraine therapy, has been
investigated,
but  sufficient  evidence  has  not been accumulated to advocate
the use of
metoclopramide in these disorders.  (50 Refs.)
  Tags: Human
  Descriptors: *Metoclopramide--Therapeutic Use--TU; Anorexia
Nervosa--Drug
Therapy--DT;  Bezoars--Drug  Therapy--DT;  Dyskinesia,
Drug-Induced --Drug
Therapy--DT; Failure to Thrive--Drug Therapy--DT; Hiccup--Drug
Therapy--DT;
Migraine--Drug Therapy--DT; Parkinson Disease--Drug Therapy--DT;
Pneumonia,
Aspiration--Drug Therapy--DT; Stomach; Vertigo--Drug Therapy--DT
  CAS Registry No.: 364-62-5   (Metoclopramide)
 
 3/L/1
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
05728979   86029979
  Potential uses for metoclopramide.
  Shaughnessy AF
  Drug Intell Clin Pharm (UNITED STATES)   Oct 1985,  19 (10)
p723-8,
ISSN 0012-6578   Journal Code: EBU
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW
  JOURNAL ANNOUNCEMENT: 8602
  Subfile:   INDEX MEDICUS
  Metoclopramide,  a  dopamine  antagonist, is approved in the
U.S. for the
treatment   of   various  gastrointestinal  disorders.  Its  use
has  been
investigated  in  a wide variety of diseases, including those not
involving
the  intestinal  tract.  Although  more  study  is  required
before routine
clinical use of metoclopramide can be advocated, it may be
effective in the
treatment  of tardive dyskinesia, in decreasing the risk factors
associated
with  anesthetic-related  aspiration, and as an adjunct in the
treatment of
gastric  bezoars.  It  also may be used safely in patients with
Parkinson's
disease.  The use of metoclopramide in the treatment of
neurogenic bladder,
orthostatic  hypotension,  tumor-associated gastroparesis,
nonprolactinemic
amenorrhea,  failure  to thrive, Tourette's syndrome, anorexia
nervosa, and
hiccups,  as well as an adjunct to migraine therapy, has been
investigated,
but  sufficient  evidence  has  not been accumulated to advocate
the use of
metoclopramide in these disorders.  (50 Refs.)
  Tags: Human
  Descriptors: *Metoclopramide--Therapeutic Use--TU; Anorexia
Nervosa--Drug
Therapy--DT;  Bezoars--Drug  Therapy--DT;  Dyskinesia,
Drug-Induced --Drug
Therapy--DT; Failure to Thrive--Drug Therapy--DT; Hiccup--Drug
Therapy--DT;
Migraine--Drug Therapy--DT; Parkinson Disease--Drug Therapy--DT;
Pneumonia,
Aspiration--Drug Therapy--DT; Stomach; Vertigo--Drug Therapy--DT
  CAS Registry No.: 364-62-5   (Metoclopramide)
 
============================================================
 
Best wishes,
 
Bob
 
--
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Robert A. Fink, M. D., F.A.C.S.   Phone: 510-849-2555
Neurological Surgery              FAX:  510-849-2557
2500 Milvia Street  Suite 222
Berkeley, California 94704-2636
USA
 
E-Mail:  [log in to unmask]
CompuServe:  72303,3442
America Online:  BobFink          "Ex Tristitia Virtus"
 
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