Here's a few more that I've downloaded from the WWW:  (see enclosures)  Wendy
T.
 
<<<<<< Attached TEXT file named "Chinese pd patients" follows >>>>>>
Debrisoquine metabolism in Chinese patients with Alzheimer's and
Parkinson's diseases.
 
Liu TY; Chi CW; Yang JC; Cheung SC; Liu HC
 
Department of Medical Research, Veterans General Hospital-Taipei, Taiwan,
ROC.
 
Mol Chem Neuropathol 17: 31-7 (1992)
 
Abstract
We determined the oxidative phenotype and metabolic ratio of debrisoquine
in 96 Chinese patients with Alzheimer's disease (n = 12), Parkinson's
disease (n = 55), and using patients with stroke and cervical spondylosis
as controls (n = 29). We did not find any difference in debrisoquine
metabolic phenotype among Parkinson's disease, Alzheimer's disease, and
control patients as judged by chi-square analysis. In addition, the
metabolic ratio of all our patients was less than 12.6. The result
suggested that Chinese patients with Parkinson's disease and Alzheimer's
disease metabolize debrisoquine at a velocity not different from that of
their Western counterparts even though the frequency distribution of
debrisoquine metabolism phenotyping in these two populations is quite
different.
 
Mesh Headings
 
     Aged
     Alzheimer's Disease*
     China
     Debrisoquin*
     Female
     Human
     Male
     Oxidation-Reduction
     Parkinson Disease*
     Phenotype
 
Unique Identifier: 93000132
 
Chemical Identifiers (Names)
 
     1131-64-2 (Debrisoquin)
 
 
<<<<<< Attached TEXT file named "debrisoquine oxidation?" follows >>>>>>
Debrisoquine oxidation in Parkinson's disease.
 
Kallio J; Marttila RJ; Rinne UK; Sonninen V; Syvalahti E
 
Department of Pharmacology, University of Turku, Finland.
 
Acta Neurol Scand 83: 194-7 (1991)
 
Abstract
Variations in the activities of xenobiotic metabolizing liver enzymes may
be involved in the pathophysiology of diseases, including Parkinson's
disease. We therefore studied the activity of the debrisoquine metabolizing
enzyme in 97 patients with newly diagnosed Parkinson's disease. The urine
debrisoquine metabolic ratios (MR) of the patients were compared with a
group of 176 healthy subjects. There were 4 poor metabolizers (4.1%) among
the parkinsonians. This proportion did not differ from that found in the
group of healthy subjects (51%). In contrast to earlier finding, the
parkinsonian poor metabolizers (PM) had the onset of the disease later than
the parkinsonian extensive metabolizers (EM). In the parkinsonian patients,
it was observed that the excretion of debrisoquine and 4-OH-debrisoquine
into urine correlated inversely with the actual age and age at disease
onset. Our results indicate that in patients with Parkinson's disease,
debrisoquine hydroxylation is comparable with healthy subjects.
 
Mesh Headings
 
     Adult
     Aged
     Aged, 80 and over
     Cytochrome P-450*
     Debrisoquin*
     Female
     Human
     Hydroxylases*
     Male
     Middle Age
     Parkinson Disease*
     Phenotype
     Support, Non-U.S. Gov't
 
Unique Identifier: 91233817
 
Chemical Identifiers (Names)
 
     EC 1.14. (Hydroxylases)
     EC 1.14.99.- (debrisoquine 4-hydroxylase)
     1131-64-2 (Debrisoquin)
     9035-51-2 (Cytochrome P-450)
 
 
<<<<<< Attached TEXT file named "etiology of pd" follows >>>>>>
Etiology of Parkinson's disease: current concepts.
 
Duvoisin RC
 
Clin Neuropharmacol 9 Suppl 1: S3-21 (1986)
 
Abstract
The etiology of Parkinson's disease remains an enigma. Yet substantial
progress toward its elucidation has been made in recent years. This disease
has emerged as a particular morbid entity with a characteristic pathology
and clinical expression. Viral encephalitis and heredity, which have long
dominated discussions of the possible causes of the disease, appear to have
been excluded. However, the possibility of a viral or subviral pathogen as
the causative factor has not been excluded. The discovery of a selective
dopaminergic neurotoxin, MPTP, which is active via any portal of entry, has
raised the question of a toxic etiology. Current attention has focused on
the search for an environmental agent. Recent studies of the Lewy body, the
pathologic hallmark of Parkinson's disease, point to possible defects in
neurofilament synthesis or transport. The finding that cultured cells from
patients with Parkinson's disease have an abnormal radiosensitivity
suggests that an acquired defect in DNA repair mechanisms may play a role.
 
Mesh Headings
 
     Atrophy
     Brain
     Cerebral Palsy
     DNA Repair
     Eosin
     Human
     Intermediate Filaments
     Parkinson Disease*
     Pyridines
     Review
     Stains and Staining
     Virus Diseases
 
Unique Identifier: 86217829
 
Chemical Identifiers (Names)
 
     28289-54-5 (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
     548-26-5 (Eosin)
 
 
<<<<<< Attached TEXT file named "International Congress on Hazar" follows
>>>>>>
[Image]
 
Agency for Toxic Substances and Disease Registry
Public Health Service
U.S. Department of Health and Human Services
    ------------------------------------------------------------------------
 
Announces:
 
The International Congress on Hazardous Waste:
Impact on Human and Ecological Health
 
Atlanta Marriott Marquis Hotel
Atlanta, Georgia
 
June 5-8, 1995
    ------------------------------------------------------------------------
 
 
A Visitor's Guide to Atlanta - Courtesy of T.R.A.V.E.L.I.N.K inc. and
Georgia Tech
 
    ------------------------------------------------------------------------
 
 
                           Congress Announcement
 
The Agency for Toxic Substances and Disease Registry announces the
"International Congress on Hazardous Waste: Impact on Human and
Ecological Health" to be held at the Atlanta Marriott Marquis
Hotel, June 5-8, 1995, in Atlanta, Georgia.  The purpose of this
Congress is to promote the exchange of findings, ideas, and
recommendations related to the human and ecological health effects
of hazardous waste.  The intended audience includes environmental
epidemiologists, toxicologists, ecologists, health scientists, and
environmental engineers from both government and academic settings;
clinical and public health physicians working in environmental and
occupational health; health educators; public health administrators
and policy makers; health, safety, and management representatives
from industry; professional environmentalists; and the interested
general public.
                                 Sponsors
 
Agency for Toxic Substances and Disease Registry, Association of
Occupational and Environmental Clinics, Association of Schools of
Public Health, Chemical Manufacturers Association, Clean Sites,
Emory University School of Public Health, Environmental Defense
Fund, International Association for Clean Technology, International
Chemical Workers, International Life Sciences Institute,
International Programme on Chemical Safety (through the World
Health Organization, the United Nations Environmental programs, and
the International Labor Organization), International Society for
Exposure Analysis, Laborers' Health & Safety Fund of North America,
National Center for Environmental Health of the Centers for Disease
Control and Prevention, National Institute of Environmental Health
Sciences of the National Institutes of Health, National Institute
for Occupational Safety and Health of the Centers for Disease
Control and Prevention, National Resources Defense Council, Pan
American Health Organization, Sierra Club, United Nations
Environmental Programme, United Nations Industrial Development
Organization, U.S. Environmental Protection Agency, and the World
Wildlife Fund.
 
                         Registration Information
 
Congress Registration may be completed by sending name,
position/title, organization, name to be listed on the name badge,
mailing address, telephone, FAX number, and a check for $200 made
out to Emory University School of Public Health ($150 if Registered
by May 15), to Emory University School of Public Health, Division
of Environmental and Occupational Health, International Congress on
Hazardous Waste, 1599 Clifton Road, N.E., Atlanta, Georgia 30329.
Attention: Dr. Howard Frumkin.  Please indicate if you are disable
or you have a condition that requires either special assistance or
accommodations.  You may print this message with the attached
Registration Form.  Full-Time Matriculating Students may register
for $100 ($50 if Registered by May 15).  Call 404-639-0708 if you
need any other information.
 
                             Hotel Information
 
A block of rooms has been reserved at the Marriott Marquis Hotel,
265 Peachtree Center Avenue, Atlanta, Georgia, 30303.  The Marriott
Marquis Hotel features a 50-story interior atrium designed by
world-renowned architect, John Portman.  It is located in the heart
of downtown Atlanta's prestigious Peachtree Center.  The hotel has
ten restaurants and lounges, an indoor/outdoor pool, a fully-
equipped health club, and a collection of boutiques.  The hotel
warrants that it is in compliance with the Americans with
Disabilities Act (Public Law 101-336) and that it will comply in
all respects with the provisions of the Act and regulations issued
thereunder.  Lodging rates for attendees is $81.00 (tax included)
per day.
                          Smoke-Free Environment
 
In keeping with applicable local ordinances, and public health
practice, Congress meeting spaces will be smoke free.
 
                              Fragrance Alert
 
Congress attendees are requested to be mindful of attendees with
fragrance allergies.
 
                       Continuing Education Credits
 
Category I Continuing Medical Education credits for physicians,
Continuing Education Units for Ph.Ds and nurses, and American
Industrial Hygiene Association points for hygienists are pending.
 
                          Pre Conference Programs
 
Saturday, June 3, 1995
 
     8:30 am - 4:30 pm.  Workshop on Risk Communication and Public
     Involvement.  First day of a two-day workshop given by US
     Environmental Protection Agency staff.  Program was well
     received when given in San Francisco.  Attendance is limited
     to 25.  Cost $200.00.  Contact 404-639-0708 for additional
     information.
 
Sunday, June 4, 1995
 
     8:30 am - 4:30 pm  Workshop on Risk Communication and Public
     Involvement (see above).
 
     2:00 pm - 4:00 pm  Workshop: "Focusing on the Unique
     Challenges and Opportunities in Operating Environmental Health
     Information Services" sponsored by the National Institute of
     Environmental health Sciences.  Contact Beth Anderson, Program
     Analyst, Superfund Basic Research and Training Program, NIEHS
     for more information: 919-541-4481.
 
     2:00 pm - 4:00 pm  Discussion: "Cumulative Risk and Human
     Susceptibility"  Contact Dr. Gershon Bergeisen, Health Science
     Advisor to the Director of the Superfund Program, US
     Environmental Protection Agency, for more information: 703-
     603-8816.
 
                                 Databases
 
A room with computers connected to the Internet and with CD-Rom
readers will be available at the Congress from 1 - 6 pm on Monday,
June 5.  This room will be open on Tuesday and Wednesday, June 6
and 7 from 8 am - 6 pm.  Congress participants can access the
Internet and WWW for a hands-on experience in searching,
retrieving, and downloading information.  A variety of data bases
will be demonstrated such as CLU-IN, VISITT, BFSS, ATTIC, ETRS,
OLS, EFIN, DWIE, DRIPSS, HazDat, EMTIC, HMIX, and OAQPS TTN.
Knowledgeable staff will be available to answer questions and to
provide assistance to Congress participants.
 
                               Refreshments
 
In keeping with Federal policy, all refreshments, snacks, and meals
(except the Monday evening social with cash bar sponsored by the
Division of Environmental and Occupational Health of Emory
University School of Public Health) will be on a cash basis.
 
                                  Social
 
Monday evening, June 5, 1995 - Poster Session and Reception 6:00 -
8:00 pm
 
Tuesday evening, June 6, 1995 - Country Line Dance Social, 8:00-
10:00 pm. (bring your boots!)
 
Wednesday evening, June 7, 1995 - on your own
 
                            Points of Interest
 
Martin Luther King Jr. Center           The Capitol
Stone Mountain Park and Laser Show      Atlanta History Center
Jimmy Carter Library and Museum         High Museum
Atlanta Botanical Gardens               Atlanta Cyclorama
Fernbank Science Center                 World of Coca-Cola
Underground Atlanta                     SciTrek
Atlanta Heritage Row Museum             Atlanta Zoo
African-American Panoramic Museum       CNN Center
Wren's Nest                             Herndon House
 
* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *
*                   International Congress on Hazardous Waste:              *
*                     Impact on Human and Ecological Health                 *
*                                                                           *
*                          CONFERENCE REGISTRATION FORM                     *
*                         (Please type or print clearly)                    *
*                                                                           *
*  Name:  (Dr./Ms./Mrs./Mr.)_____________________________________________   *
*                                  (to appear on name badge)                *
*                                                                           *
*  Position/Tile:  ______________________________________________________   *
*                                                                           *
*  Organization:  _______________________________________________________   *
*                                     (to appear on name badge)             *
*                                                                           *
*  Mailing Address: ____________________________________________________    *
*                                                                           *
*  _____________________________________________________________________    *
*                                                                           *
*  Street Address:  _____________________________________________________   *
*                                                                           *
*  City:  _______________________________  State: _______ Zip:___________   *
*                                                                           *
*  Country:  ____________________________________________________________   *
*                                                                           *
*  Telephone: (_______)___________________________________________________  *
*                                                                           *
*  E-Mail Address:  ______________________________________________________  *
*                                                                           *
*  Registration Fees:                                                       *
*                                                                           *
*  Early Registration - $150                 On-Site Registration - $200    *
*                                                                           *
*  Full-Time Matriculating Students:                                        *
*                                                                           *
*  Early Registration - $50                  On-Site Registration - $100    *
*                                                                           *
*  For early registration, please mail this form with your check for $150   *
*  ($50 for students) to arrive by May 15, 1995, and payable to:            *
*                                                                           *
*         Emory University School of Public Health                          *
*         Division of Environmental and Occupational Health                 *
*         International Congress on Hazardous Waste                         *
*         1599 Clifton Road, N.E.                                           *
*         Atlanta, Georgia  30329                                           *
*         Attention:  Dr. Howard Frumkin                                    *
*         Telephone:  (404) 727-3697                                        *
*         Fax:  (404) 727-8744                                              *
*                                                                           *
*  Cancellation Policy                                                      *
*                *
            *
*  All cancellations must be made in writing and mailed or faxed to         *
*  Emory University School of Public Health.  A full refund will be given   *
*  if written notice is received by May 30, 1995.  A $50 administrative     *
*  fee will be deducted from any refund request received after the cancel-  *
*  lation date.                                                      *
*                                                                           *
*  (   )  REQUEST FOR SPECIAL ASSISTANCE:  If you are disabled or have a    *
*         condition that requires either special assistance or              *
*         accommodations, please check at left.  We will call you to        *
*         discuss your specific needs.                                      *
* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *
         International Congress on Hazardous Waste:
                      Impact on Human and Ecological Health
 
                             Tentative Program
 
Sunday, June 4, 1995
 
      6:00 pm - 9:00 pm  Registration
 
Monday, June 5, 1995
 
      7:00 am - 5:00 pm  Registration
 
      8:00 am - 8:30 am  Opening Session
 
                    Welcome. D. Satcher, Centers for Disease
                    Control and Prevention and Agency for Toxic
                    Substances and Disease Registry
 
                    Charge to the Congress. K. Olden, National
                    Institute of Environmental Health Sciences
 
      8:30 am - 10:00 am Plenary Session
 
               Hazardous Waste: State of the Environment. E. Laws,
               U.S. Environmental Protection Agency
 
               Hazardous Waste: Biomarkers and Ecological Health
               Effects. S. Anderson, Lawrence Berkeley Laboratory
 
     10:00 am - 10:30 am Break
 
     10:30 am - noon     Plenary Session
 
               Hazardous Waste:  Human Health Effects.  B Johnson,
               Agency for Toxic Substances and Disease Registry
 
               Environmental Contamination and Health Effects:
               What is the Evidence?  L. Sever, Battelle Pacific
               Northwest Laboratories
 
      noon - 1:30 pm          Lunch (on your own)
 
      1:30 pm - 3:00 pm  Concurrent Breakout Sessions
 
Session 1 - (Health Effects Track) Health Effects of Incinerators
and Other Airborne Exposures
 
     Residential Health Impact of Large-Scale On-Site Incineration
     of Dioxin-Like Compounds. M. F. Cranmer, Cranmer and
     Associates, Inc.
 
     Cardiac and Respiratory Symptoms Associated with Exposure to
     the Incineration of Hazardous Waste. C. A. Hornung, University
     of South Carolina
 
     The Fort Hall Air Emissions Study. S. W. Metcalf, Agency for
     Toxic Substances and Disease Registry
 
     Neurological Alterations in Children Exposed to Arsenic Lead
     and Cadmium in San Luis Potosi, Mexico. M. E. Cebrian,
     Instituto Politecnico Nacionale
 
Session 2 - (Health Effects Track) Health Studies Near Hazardous
Waste Sites
 
     Health Outcomes Among Residents Living Adjacent to a Hazardous
     Waste Site. M. S. Miller, Agency for Toxic Substances and
     Disease Registry
 
     Health Risks Among Residents Living Near a Superfund Site -
     Tucson, Arizona. R. A. Rao, Agency for Toxic Substances and
     Disease Registry
 
     A Health Assessment of Three Communities Near Oxidation
     Lagoon, in the State of Mexico. M. A. Karam, Public Health
     Research Center
 
     End Stage Renal Disease and Exposure to Hazardous Waste. H. I.
     Hall, Agency for Toxic Substances and Disease Registry
 
Session 3 - (Ecology Track) Use of Wildlife to Evaluate Transport
and Exposure
 
     Lead Levels in Exposed Herring Gulls: Differences in the Field
     and Laboratory. J. Burger, Rutgers University
 
     Non-lethal Methods of Assessing Wildlife Exposure to
     Contaminants. G. P. Cobb, Clemson University
 
     Integrated Laboratory and Field Studies of Contaminant
     Exposure in Badgers (Taxidea taxus) Inhabiting the Rocky
     Mountain Arsenal. D. J. Hoff, U.S. Fish and Wildlife Service
 
     Trans-boundary Movement of Metals from Benthic Sediments into
     Terrestrial Small Mammals at Hazardous Waste Sites. T. W. La
     Pointe, Agency for Toxic Substances and Disease Registry
 
Session 4 - (Exposure Assessment Track) Demographic Analysis of
Susceptible Populations
 
     Using Geographic Information Systems to Estimate Populations.
     J. Heitgerd
 
     GIS Studies of Cancer Around NPL Sites. T. E. Aldrich,
     University of North Carolina
 
     Race, Ethnicity, and Poverty Status of Populations Living Near
     Cement Plants and Commercial Incinerators.  L. M. Harris, U.S.
     Environmental Protection Agency
 
     The Role of Demographics in Public Health Assessments at
     Superfund Sites:  A Case Study of Rocky Mountain Arsenal. E.
     W. Gregory, Jr., Agency for Toxic Substances and Disease
     Registry
 
Session 5 - (Community Involvement Track) Community Case Studies I
 
     When Federal Agencies Come to Town:  Communication and
     Community Involvement -- Learning by Doing in Stratford. A. L.
     Boissevain, Health Risk Consultants, Inc.
 
     A Framework for Involving Communities Living Near Hazardous
     Waste Sites in Federal Public Health Actions. L. C. Campbell,
     Agency for Toxic Substances and Disease Registry
 
     Getting the Public's Ideas on Public Involvement:  A Case
     Study. K. J. Black, Neptune and Company, Inc.
 
     A Wisconsin Comprehensive Approach to Community Involvement.
     M. R. Young, Wisconsin Division of Health
 
Session 6 - (Biological Markers Track) Biomarkers
 
     Use of Endocrine Biomarkers in Risk Assessment. R. L.
     Dickerson, Clemson University
 
     Chromosomal Aberrations in Blood Lymphocytes are the
     Biomarkers of Human Exposure to Radiation or/and Chemicals. I.
     I. Suskov, Russian Academy of Sciences
 
     Monitoring Methyl Parathion Exposure in Loraine County, Ohio
     with urinary p-Nitrophenol Measurements. R. H. Hill, Jr.,
     Centers for Disease Control and Prevention
 
     Methyl Parathion Contamination of Private Residences: Risk
     Assessment and Risk Management Approaches. J. Milton Clark
 
Session 7 - (Engineering Track) Remediation Techniques
 
     In situ Remediation of Woodtreating Waste Contaminated with
     Pentachlorophenol (PCP). J. M. Croom, Quantitative
     Applications, Inc.
 
     Biodegradation of Phenanthrene in Soil in the Presence of
     Nonionic Surfactants. W. J. Maier, University of Minnesota
 
     Soil Gas Entry into Below Grade Basements as an Exposure Route
     to Trichloroethene. C. G. Uchrin, Rutgers University
 
     Novel Systems for Promoting the Reductive Dehalogenation of
     Carbon Tetrachloride. R. G. Arnold, University of Arizona
 
Session 8 - (Risk Assessment Track) Case Studies in Risk Assessment
 
 
     Lead Soil Remediation:  The Quebec Experience of Specific Site
     Assessment. P. Levallois, Centre de Sante Publique de
     Quebec/Universite Laval
 
     Factors Affecting Risks from Facilities Burning Hazardous
     Waste. D. A. Canter, U.S. Environmental Protection Agency
 
     Some Approaches to the Classification of Radioactive Wastes.
     A. N. Varbanets, Ukrainian Scientific Hygienic Centre
 
     A Fish Consumption Survey of the Tulalip and Squaxin Island
     Tribes. K. A. Toy, Tulalip Tribes
 
Session 9 Navigating the Informational Maze: Internet, the World
Wide Web, CD-ROMs, and Bulletin Boards
 
     Internet and the World-Wide Web. L. M. Perry, Agency for Toxic
     Substances and Disease Registry
 
     Accessing the NIEHS Superfund Basic Research Program's
     Information Systems. B. Anderson, National Institute of
     Environmental Health Sciences. B. Anderson
 
     TBA
 
     What Else Is In the World?  G. Alston, Agency for Toxic
     Substances and Disease Registry
 
      3:00 pm - 3:30 pm  Break
 
      3:30 pm - 5:00 pm  Concurrent Breakout Sessions
 
Session 10 - (Health Effects Track) Health Outcomes in Children
 
     Identification of Risk Factors Associated with Human Exposure
     to Fluoride. F. Diaz-Barriga, Universidad Autononoma de San
     Luis Potosi
 
     Performance of Cytogenetic Biomarkers on Children Populations
     Exposed to Environmental Pollutants:  A Three Years
     Longitudinal Study. T. Lakhanisky, Institute of Hygiene and
     Epidemiology
 
     Subclinical Health Effects of Environmental Pesticide
     Contamination in a Third World Setting:  Cholinesterase
     Depression in Children. R. McConnell, Pan American Center for
     Human Ecology and Health
 
     Using Patterns of Child Growth and Development to Assess
     Community-wide Effects of Low-Level Exposure to Toxic
     Materials. L. M. Schell, University of Albany, State
     University of New York
 
Session 11 - (Health Effects Track) Abnormal Immune Findings in
ATSDR Studies
 
     Overview of the Agency for Toxic Substances and Disease
     Registry's Multisite Database. M. A. McGeehin, Agency for
     Toxic Substances and Disease Registry
 
     Adoption of an Immune Function Test Battery for Environmental
     Health Studies. R. W. Amler, Agency for Toxic Substances and
     Disease Registry
 
     Detection of Chronic Lymphocytic Leukemia-Like Monoclonal B-
     cell Proliferation in Peripheral Blood Samples from
     Environmental Health Studies. R. F. Vogt, Jr., Centers for
     Disease Control and Prevention
 
     Public Health Implications of Abnormal Immune Findings in
     ATSDR's Multisite Database. J. A. Lybarger, Agency for Toxic
     Substances and Disease Registry
 
Session 12 - (Ecology Track) Bioaccumulation and Fate in Ecological
Systems
 
     The Bioaccumulation of PAHs, PCBs and PCDFs from Sediments by
     Chironomus Tentans Larvae in the Laboratory and Caged Carp in
     the Field. P. W. O'Keefe, New York State Department of Health
 
     Toxicity and Bioaccumulation of a Mixture of Heavy Metals in
     Chironomus tentans (Diptera: Chironomidae in Sediment. E. A.
     Harrahy, Colorado State University
 
     Biological Control of the Flux of Heavy Metals from
     Contaminated Marine Sediments. T. E. Ford, Harvard School of
     Public Health
 
     Accumulation of Copper, Lead and Cadmium in Snail Intermediate
     Hosts of Schistosomiasis and Fascioliasis in Southwest
     Nigeria. C. O. Adewunmi, University of Hamburg
 
Session 13 - (Exposure Assessment Track) Exposure Assessment
 
     Use of Molecular Similarity in the Assessment of Toxicity of
     Chemicals. S. C. Basak, University of Minnesota
 
     Groundwater and Contaminant Modeling for Exposure Assessment.
     J. A. Mundell, ATEC Associates, Inc.
 
     Using Measured Contaminant Concentrations Versus Modeling
     Results for CERCLA-Related Air Pathway Risk Assessments. S. A.
     Smith, Radian Corporation
 
     A Case Study in Evaluating Radiation and Chemical Exposures:
     Hunters Point Annex. J. Davis, Agency for Toxic Substances and
     Disease Registry
 
Session 14 - (Community Involvement Track) Community Case Studies
II
 
     Community Involvement in Public Health Investigations:
     Improved Response and Data Collection Using Neighborhood
     Volunteers in a South Texas City. B. G. Brown, Texas
     Department of Health
 
     Community as Partners: A Case Study: Partnering Federal and
     Local Health Agencies with Community Members to Plan,
     Implement, and Evaluate a Health Education Program. D.
     Middleton, Agency for Toxic Substances and Disease Registry
 
     The Process of Community Involvement - A Case Study:  The
     Bartlesville, Oklahoma Lead Project. M. J. Elder, Oklahoma
     Department of Environmental Quality
 
     Local Health Department Activity at Hazardous Waste Sites:  A
     Spectrum of Responses. H. M. Klein, National Associate of
     County and City Health Officials
 
Session 15 - (Biological Markers Track)  XRF in the Assessment of
Lead Exposure
 
     Clinical Research Results Using L-Line-X-Ray Fluorescence
     (LXRF) in Lead (Pb) Exposed and Non-Pb-Exposed Children,
     Teenagers and Adults. J. F. Rosen, Montefiore Medical Center
 
     Body Burden of Lead in a Cohort of Women Formerly Employed at
     a Lead Smelter. C. V. Lee, Agency for Toxic Substances and
     Disease Registry
 
     X-Ray Fluorescence Results in Bunker Hill Residents Exposed to
     Lead and a Sample from the General Population. L. D. Stokes,
     Agency for Toxic Substances and Disease Registry
 
     TBA
 
Session 16 - (Engineering Track) Remediation Approaches
 
     A Structured Approach to Remediation. G. F. Vajda, Dames &
     Moore, Inc.
 
     Expedited Site Characterization by a Dynamic Process that
     Employs Field Analytics.  A. Henderson-Kinney, Tufts
     University
 
     Resource Allocation Modeling in Environmental Monitoring
     Design. R. Kuchibhatla, ManTech Environmental Technology, Inc.
 
     Costs and Benefits of the RCRA Corrective Action Program:  A
     National Perspective. B. Johnson, U.S. Environmental
     Protection Agency
 
Session 17 - (Risk Assessment Track) Strategies for Risk Assessment
 
 
     Comparative Risk Analysis:  A Panacea or Risky Business? V.
     Molak, GAIA Unlimited, Inc.
 
     A Survey of Perceptions of Environmental Risks:  A Comparative
     Risk Approach at the Local Level. V. R. Nathan, Wayne State
     University
 
     Health Hazards of Hazardous Waste Sites Identified Through
     Petitions for Public Health Assessments. J. A. Steward, Agency
     for Toxic Substances and Disease Registry
 
     Health-based Contaminant Screening Levels. D. M. Abouelnasr,
     Agency for Toxic Substances and Disease Registry
 
Session 18 - Environmental Justice
 
     Small Area Analysis Techniques for Environmental Justice in
     Minority and Disadvantaged Communities. E. A. Taylor, Centers
     for Disease Control and Prevention
 
     Washtenaw County (MI) Environmental Justice Community Outreach
     Program. R. A. Head, Washtenaw Department of Environment &
     Infrastructure Services
 
     Environmental Justice and an Urban Community:  A Unique
     Approach at a Superfund Site.  P. K. Seppi, U.S. Environmental
     Protection Agency
 
     Hazardous Waste Disposal Decisions:  Democracy, Justice and
     NIMBYism. H. Elliott
 
      6:00 pm - 8:00 pm  Poster Session and Reception.
 
Tuesday, June 6, 1995
 
      7:00 am - 5:00 pm  Registration
 
      8:30 am - 10:00 am Plenary Session
 
                    Environmental Justice: Strategies for
                    Achieving Health and Sustainable Communities.
                    R. Bullard, Clark Atlanta University
 
                    Hazardous Waste and Risk Assessment --
                    Safeguarding Children and Other Sensitive
                    Populations. L. Goldman, Environmental
                    Protection Agency
 
     10:00 am - 10:30 am Break
 
     10:30 am - 12:05    Plenary Session
 
                    2 X 2 Tables:  A Wolf in Sheep's Clothing. D.
                    Ozonoff, Boston University
 
                    Update on Hazardous Waste Worker Protection.
                    R. Lemen, National Institute for Occupational
                    Safety and Health
 
                    Workers and the Hazardous Waste Business. A.
                    A. Coia, Laborer's International Union of
                    North America
 
      noon - 1:30 pm     Lunch (on your own)
 
      1:30 - 3:00 pm     Plenary Session
 
                    Physician Education. T. Walton, National
                    Medical Association
 
                    Hazardous Waste and Community Voice: Moving
                    Toward Solutions. R. Cox, Sierra Club
 
      3:00 pm - 3:30 pm  Break
 
      3:30 pm - 5:00 pm  Concurrent Breakout Session
 
Session 19 - (Health Effects Track) Cancer
 
     Brain Cancer and Multiple Hazardous Exposures, Especially EMF.
     T. E. Aldrich, University of North Carolina
 
     Case-Control Study of Lung Cancer Mortality in Four Arizona
     Smelter Towns. G. M. Marsh, University of Pittsburgh
 
     A Study of Cancer Mortality of Louisiana Parishes in Relation
     to Environmental and Occupational Factors. A. E. Gomaa, Agency
     for Toxic Substances and Disease Registry
 
     Pancreatic Cancer Mortality and Railroad Refueling Facilities
     in Montana. S. R. Prausnitz, Agency for Toxic Substances and
     Disease Registry
 
Session 20 - (Health Effects Track) Adverse Reproductive Outcomes
 
     Birth Defects, Fetal Loss and Developmental Disorders in an
     Eleven Year Study of an Herbicide Manufacturing Facility with
     Dioxin Contamination. M. A. Brewster, Arkansas Children's
     Hospital
 
     A Community-based Study of Adverse Pregnancy Outcomes Near a
     Large Hazardous Waste Landfill in California. M. Kharrazi,
     California Department of Health Services
 
     Maternal Residential Exposure to Hazardous Waste Sites and the
     Risk of Central Nervous System and Musculoskeletal Birth
     Defects. E. G. Marshall, New York State Department of Health
 
     The Relationship between Birth Defects and Oral Exposure to
     Trichloroethylene-Contaminated Water in Woburn, Massachusetts.
     D. Schendel, Centers for Disease Control and Prevention
 
Session 21 - (Ecology Track) Modeling to Assess Ecological and
Human Risk
 
     Assessing Human Exposure to Air and Soil Contaminant through
     Homegrown Foods:  Defining the Significant Factors. T. E.
     McKone, University of California
 
     Uncertainty in the Use of Plant Uptake factors in Exposure
     Assessments for Wildlife. K. M. Morgan, Oak Ridge National
     Laboratory
 
     An Assessment of Exposure from Anthropogenic Mercury Emissions
     in the U.S. G. Rice, US Environmental Protection Agency
 
     Integrated Assessment of Ecological and Human Health Risk of
     Mercury Exposure. R. Schoeny, US Environmental Protection
     Agency
 
Session 22 - (Exposure Assessment Track) General Exposure
 
     Effect of Variability in Estimated Half-Lives of PCBs in
     Humans on Exposure Assessment. J. C. Kissel, University of
     Washington
 
     Redefinition of Abnormal Susceptibility to Environmental
     Chemicals. W. E. Morton, Oregon Health Sciences University
 
     Use of Data Gap Sampling and Analysis Plans to Prepare US Air
     Force Installations for ATSDR Public Health Assessments. J. R.
     Wireman, US Air Force
 
     Human Exposure to Methyl Parathion in Private Residences,
     Ohio. E. Esteban, Centers for Disease Control and Prevention
 
Session 23 - (Community Involvement Track) Community Case Studies
III
 
     Organization Industrial Waste in Samarita, Sao Vicente City,
     SP, Brazil. A. Soares, Sec Higiene E. Saude de Santos
 
     Dumping on a Community:  A Tale of Waste. M. B. Harwitz,
     Munisport Dump Coalition, Inc.
 
     Public Input and Involvement in the Selection of Exposure and
     Health Outcome Studies:  A Case Study of Jacksonville,
     Arkansas. M. F. Cranmer, Cranmer and Associates, Inc.
 
     The Use of Wildlife Toxicology in Ecological Risk Assessment
     of Hazardous Waste Sites:  Assessment, Litigation, and
     Remediation. R. J. Kendall, Clemson University
 
Session 24 - (Toxicology Track) - Toxicology
 
     Guidelines for Assessing Adverse Health Effects. M. D.
     Williams, Agency for Toxic Substances and Disease Registry
 
     The Health Effects of Chronic Oral Exposure to Polychlorinated
     Biphenyls. O. M. Faroon, Agency for Toxic Substances and
     Disease Registry
 
     Rapid Assessment of Chemical Contamination and Determination
     of Toxicity Equivalents at a Hazardous Waste Site. W. E.
     Mashburn, Clemson University
 
     Studies on the Toxic Impact of Hazardous Waste:
     Organophosphate Insecticide Induced Impairment in
     Catecholaminergic system of Developing Brain and Heart in a
     Mammalian Model. Dr. Nayeemunnisa, Bangalore University
 
Session 25  - (Engineering Track) Engineering Approaches Based on
Risk Assessment
 
     Risk Assessment and Remediation at the Seymour Superfund Site:
     A Case Study. S. T. Atwood, Geraghty & Miller, Inc.
 
     The Georgia Hazardous Site Response Program:  Using a Risk
     Based Approach to Determine Clean-up Levels in Soils and
     Groundwater. K. L. Mitchell, Georgia Department of Natural
     Resources
 
     Construction Within a Contaminated Area:  When is it Feasible?
     L. M. Smith, Law Engineering & Environmental Services, Inc.
 
     The Use of Natural Mineral Sorbents in Medicine, Agriculture
     and Ecology. K. M. Sinyak, Universitat Hamburg
 
Session 26 - International
 
     Environmental Health Activities on the Texas-Mexico Border. R.
     J. Dutton, Texas Department of Health
 
     Regional Agreements on the Transboundary Movement of Hazardous
     Waste:  Efforts Toward Sustainable Development. C. Warrick,
     Agency for Toxic Substances and Disease Registry
 
     The Silent Trade of Hazardous Wastes into Lebanon:  A Case
     Study. M. Jurdi, American University of Beirut
 
     Contaminations of Environment and Public Health:  Arguments
     for International Collaboration. L. T. Shevchuk, Lviv State
     University
 
Session 27 - (Risk Communication and Education Track) Community I
 
     A Model for Medical Education for Widely Dispersed Physicians.
     A. P. Janssen, Agency for Toxic Substances and Disease
     Registry
 
     Developing Successful Environmental Physician Education:
     Lessons Learned. R. R. Tardif, Oak Ridge Institute for Science
     and Education
 
     Strategies for the Prevention of Mercury Exposition among
     Adolescents from Gold Mining Areas. V. de M. Camara, Federal
     University of Rio de Janeiro
 
     Community-Based Strategies for Communicating Environmental
     health Risks: A Case Study of the Chattanooga Creek Site. T.
     Tinker, Agency for Toxic Substances and Disease Registry
 
Wednesday, June 7, 1995
 
      7:00 am - 5:00 pm  Registration
 
      8:30 am - 10:00 am Plenary Session
 
                    Environmental Contaminants as Endocrine
                    Disrupters. L. Gillette, University of Florida
 
                    Environmental Estrogens: Is There a Human
                    Health Problem? S. Safe, Texas A & M
                    University
 
     10:00 am - 10:30 am Break
 
     10:30 am - 12:05 pm Plenary Session
 
                    Indigenous People. T. Goldtooth, Indigenous
                    People Environmental Network
 
                    Cleaning It Up. P. Seligman, Department of
                    Energy
 
                    Ecogenetics: From Ecology to Health. D.
                    Nebert, University of Cincinnati
 
     12:05 pm - 1:30 pm  Lunch (on your own)
 
      1:30 pm - 3:00 pm  Concurrent Breakout Session
 
Session 28 - (Health Effects Track) Neurobehavioral Outcomes
 
     Subject Factors Affecting Performance on ATSDR's Adult
     Environmental Neurobehavioral Test Battery (AENTB). W. K.
     Anger, Oregon Health Science University
 
     Chronic Neurotoxicity as a Result of Landfill Exposure in Port
     Orchard, Washington. A. R. Hirsch, Smell & Taste Treatment and
     Research Foundation
 
     Toxic Encephalopathy:  Evaluation by Neuroselective Cephalic
     Transcutaneous Electrical Nerve Stimulation and Comparison
     with other Tests. J. J. Katims, Neurotron, Inc.
 
     Psychologic Concerns of Communities Near Hazardous Waste
     Sites. P. G. Tucker, Agency for Toxic Substances and Disease
     Registry
 
Session 29 - (Health Effects Track) Lead Exposure in Children
 
     A Case-Control Study to Determine Risk Factors for Elevated
     Blood Lead Levels in Children:  The Idaho Silver Valley. M. M.
     Nogueras, Agency for Toxic Substances and Disease Registry
 
     Use of Stable Lead Isotope Systematics to Identify and
     Apportion Sources of Environmental Lead in Residential House
     Dust. P. J. Ashley, Maryland Department of the Environment
 
     Measuring Lead on Hands for Assessing and Preventing Childhood
     Exposure. H. W. Mielke, Xavier University of Louisiana
 
     Environmental Lead Exposure and Blood Lead Levels among
     Children of Mexico City. I. Romieu, Instituto Nacional De
     Salud Publica
 
Session 30 - (Ecology Track) Ecological Assessments
 
     Preliminary Ecological Risk Assessment at a National
     Priorities List Site in South Carolina. G. P. Cobb, Clemson
     University
 
     Biomarkers in Endemic, Enhanced and Enclosed Wildlife: Their
     Use in Contaminant Bioavailability Assessments. M. J. Hooper,
     Clemson University
 
     Biochemical Assessment of Cyanide-induced Toxicity in
     Migratory Birds from Gold Mining Hazardous Waste Ponds. C. A.
     Pritsos, University of Nevada
 
     A Model Insect as a Biomarker of Mercury Toxicity in Mammals.
     S. Ahmad, University of Nevada
 
Session 31 - (Exposure Assessment Track) - Air Exposure
 
     The Use of Breath Samples as the Indicator of Internal Dose
     after Tetrachloroethylene Exposure.  C. P. Weisel, Rutgers
     University & UMDNJ-Robert Woods Johnson Medical School
 
     Exposure Assessment for Toxic Air Pollutants from Hazardous
     Waste Incineration: The Vertac/Hercules Superfund Site. L.-J.
     S. Liu, University of South Carolina
 
     Evaluation of Potential Exposure to Nearby Residents from the
     Operation of a Hazardous Waste Incinerator at the
     Vertac/Hercules Superfund Site. M. F. Cranmer, Cranmer and
     Associates, Inc.
 
     The Lower Rio Grande Valley Environmental Monitoring Study:
     Applying Human Exposure Science to Public Health Concerns. M.
     Schwab, ManTech Environmental Technology, Inc.
 
Session 32 - (Workers Track) - Worker Exposure to Heavy Metals
 
     Exposure Assessment for Heavy Metals in Oruro, Bolivia, 1994.
     S. H. Wainwright, Centers for Disease Control and Prevention
 
     Exposure of Workers in Recycling of Hazardous Lead Batteries'
     Wastes in India. J. M. Dave, Jawaharalal Nehru University
 
     Effects of Automobile Wastes on the Health of Roadside
     Mechanics. M. K. C. Sridhar, University of Ibadan
 
     Use of Historical Data in a Contemporary Public Health
     Assessment of a Uranium Mill. K. Silver, Boston University
 
Session 33 - (Toxicology Track) - Toxicology of Chemical Mixtures
 
     Effect of Vitamin & Mineral Intake on Toxicity of Complex
     Mixture (Arsenic, Benzene, Cadmium, Lead and
     Trichloroethylene). B. W. Kemppainen, Auburn University
 
     The Mechanism of Polychlorinated Biphenyl (PCB)-Neurotoxicity.
     B. Jahan-Parwar, State University of New York
 
     Effect of Ozonation on the Epigenetic Toxicity of Polycyclic
     Aromatic Hydrocarbons. S. J. Masten, Michigan State University
 
     Toxicity Assessment of Inorganic Chemical Mixtures Found at
     Hazardous Waste Sites. M. M. Mumtaz, Agency for Toxic
     Substances and Disease Registry
 
Session 34 - (Policy Track) Community Policy
 
     Confronting Superfund Mythology: The Case of Risk Assessment
     and Management. K. D. Walker, Harvard University
 
     Locking in Environmental Risk: A Model Environmental and
     Health Baseline Ordinance. B. S. Ruhl, Legal Environmental
     Assistance Foundation, Inc.
 
     Building Neighborhood Based Programs for Site Remediation and
     Redevelopment. J. A. Shaw, New Jersey Department of
     Environmental Protection
 
     Small Communities of Argentina React to the Transfer of
     Hazardous Wastes Technologies. M. N. Epelman, Environmental
     Commission, City Council of Buenos Aires
 
Session 35 - (Risk Assessment Track) - Methods and Guidelines for
Health Risk Assessment - Session I
 
     An Approach to Exposure Analysis that Identifies the Types of
     Data and Data Groups Associated with Remedial Investigations,
     and Then Identifies Ways to Reduce Uncertainties. P. J. Lioy,
     Environmental and Occupational Health Sciences Institute
 
     Risk Assessment of Dioxin Congeners via Plant Uptake. B. H.
     Magee, Ogden Environmental & Energy Services
 
     Risk Assessment and Management for Highly Toxic Air and Water
     Emissions and solid Wastes: A Case Study. S. Dhara, Children's
     Science Congress
 
     The Relationship Between Site Characteristics and Reported
     Health Conditions. D. Abouelnasr, Agency for Toxic Substances
     and Disease Registry
 
Session 36 - (Risk Communication and Education Track) - Community
II
 
     Communication and Negotiation at Hazardous Waste Sites:  Some
     Psychological and Sociological Influences on Scientific
     Debate. H. Tosteson, Agency for Toxic Substances and Disease
     Registry
 
     Why Aren't You Listening?  The Need for an Environmental Needs
     Assessment Survey. H. H. Lenz, Oregon State University
 
     The Spirit of our Times:  Forging the Way to a Better
     Understanding of Public Health Concerns at Federal Facility
     Sites. V. H. Sublet, University of Cincinnati
 
     Citizen Participation and Empowerment in the Context of Local
     Environmental Hazards. R. C. Rich, Virginia Tech
 
      3:00 pm - 3:30 pm  Break
 
      3:30 pm - 5:00 pm  Concurrent Breakout Session
 
Session 37 - (Health Effects Track) - Health Studies Following
Hazardous Waste Exposures
 
     Environmental Contamination by Hexachlorocyclohexane in a
     Large Area in Rio de Janeiro - Brazil.  A. M. C. B. Braga,
     Oswaldo Cruz Foundation
 
     Airborne Cyanide Pollution. T. R. Oesch, Martin Marietta
     Energy Systems
 
     Cancer Risks in an Arsenic Contaminated Area of Chile. M. I.
     Rivara Z, Chile Ministry of Health
 
     Mortality Study of Children Residing Near ASARCO Copper
     Smelter in Ruston, Washington:  Cohort construction and
     Follow-up. F. Westrum, Washington State Department of Health
 
Session 38 - (Health Effects Track) - Epidemiology and Hazardous
Waste
 
     Combining Qualitative and Quantitative Approaches to Assessing
     Hazardous Waste Impacts on Human Health and Well-Being in
     Local Community Studies. D. C. Cole, McMaster University
 
     Risk Factors of Hazardous Substance Releases Resulting in
     Personal Injuries and Evacuations. H. I. Hall, Agency for
     Toxic Substances and Disease Registry
 
     Environment-Related Cancer Surveillance. Y. Mao, Health Canada
 
     The Relationship Of The Level and Length of Mixed Chemical
     Exposures To Reporting Rates of Adverse Health Outcomes:  A
     Multisite Approach. J. R. Burg, Agency for Toxic Substances
     and Disease Registry
 
Session 39 - (Ecology Track) - Ecology and Human Exposure
 
     Risk Characterization of Methylmercury Effects on Human
     Populations and Wildlife Species:  Fish Mercury Content and
     Fish Consumption as Contributors to Uncertainty and
     Variability.  K. R. Mahaffey, US Environmental Protection
     Agency
 
     Human and Ecological Exposure Pathways via Food-Chain at Air
     Force Sites. Maj. B. J. Larcom, US Air Force
 
     Retention of Ingested Benzo(a)pyrene and Related Aromatic
     contaminants in Hens, Pigs, and Cows. S.-C. Tsai, Agency for
     Toxic Substances and Disease Registry
 
     TBA
 
Session 40 - (Exposure Assessment Track) - Exposures at Smelters
and Incinerators
 
     Lead Exposure in Children Living Near a Smelter Complex in the
     USA-Mexican Border. F. Diaz-Barriga, Universidad Autononoma de
     San Luis Potosi
 
     Quantifying Individual-level Lifetime Residential Exposure to
     SO2 in Four Arizona Copper Smelter Communities:  Statistical
     Issues. R. A. Stone, University of Pittsburgh
 
     Quantifying Individual Residential Exposure to Smelter
     Emissions in Four Arizona Copper Smelter Communities:
     Exposure Estimation Procedures and Results. N. A. Esmen, Esmen
     Research and Engineering
 
     Exposure Assessment at a Former Mining Site:  The Kansas
     Experience. R. Dhara, Agency for Toxic Substances and Disease
     Registry
 
Session 41 - (Workers Track) - Worker Exposures
 
     Neurotoxicity as a Result of Acute Nitrogen Tetraoxide
     Exposure. A. R. Hirsch, Smell & Taste Treatment and Research
     Foundation
 
     Assessment of Toxic Exposures in Waste Incineration. S. K.
     Hall, William Paterson College
 
     Exposure Assessment of Workers at Hazardous Waste Sites Based
     on Concurrent Environmental Monitoring and Breath Sampling. C.
     J. Komis, US Department of Labor
 
     The Cleanup of Clandestine Drug Laboratories:  A Planning and
     Program Implementation Guide. R. P. Hill, Centers for Disease
     Control and Prevention
 
Session 42 - Laboratory
 
     New, Fast, Ultra-sensitive Analytical Methods for Assessing
     Human Exposure to Environmental Toxicants. D. G. Patterson,
     Jr., Centers for Disease Control and Prevention
 
     Quantification of Non-persistent Pesticides by Isotope
     Dilution-High Resolution Mass Spectrometry. J. Barr, Centers
     for Disease Control and Prevention
 
     Measurement of Radionuclides in Human Biological Specimens. W.
     Ting, Centers for Disease Control and Prevention
 
     Biological Monitoring of methyl tert-Butyl Ether in Controlled
     Chamber Experiments and Site Investigations. D. L. Ashley,
     Centers for Disease Control and Prevention
 
Session 43 - Policy
 
     Who Sets the Environmental Agenda? D. B. Sachsman, University
     of Tennessee at Chattanooga
 
     Science Put to Service:  Enhancing Environmental Health
     Services in Communities Affected by Hazardous Substances. M.
     Y. Lichtveld, Agency for Toxic Substances and Disease Registry
 
     Incidents of Large Scale Lead Poisoning in East Trinidad:  A
     Dire Need for Sustainable Practices in Hazardous Waste
     Disposal. I. Chang-Yen, University of the West Indies
 
     Uncertainty and Causation in the Law:  Towards a Common
     Practice do Deal with Risks. P. F. Ricci, Ricci and Molton
 
Session 44 - (Risk Assessment Track) - Methods and Guidelines for
Health Risk Assessment - Session II
 
     A New Approach for the Study of Hazardous Waste Sites in
     Mexico. F. Diaz-Barriga, Universidad Autononoma de San Luis
     Potosi
 
     A Multi-Plant, Multi-Pathway Risk Screening of Waste Kiln-Dust
     Management at U.S. Portland Cement Plants. F. A. Smith, US
     Environmental Protection Agency
 
     Exposure Guidelines Based on Total Recipient Dose and Not
     Proposed Air Levels. A. Winnert, Environmental & Toxicology
     International, Inc.
 
     A Risk-based Approach for Setting Site Evaluation Priorities
     in Former Gazwork Sites in France:  A National Survey. D.
     Zmirou, Grenoble University Medical School
 
Session 45 - (Risk Communication and Education Track) - Community
III
 
     Above and Beyond Basic Public Participation. L. P. Mathai,
     Neptune and Company, Inc.
 
     A Newsletter "Health and Waste Network."  M. Hours, Universite
     C. Bernard Lyon I.
 
     To Clean the Environment, Catch Them Young:  The 1994
     Children's Science Congress Experience. S. Dhara, Children's
     Science Congress
 
Thursday, June 8, 1995
 
      7:00 am - noon     Registration
 
      8:30 am - 10:00 am Plenary Session
 
                    Limitations of Clinical Laboratory Data for
                    Environmental Health Diagnosis.  H. Kipen,
                    UMDNJ-Robert Wood Johnson Medical School
 
                    Innovative Technologies for Site Clean-up. W.
                    Kovalick, Environmental Protection Agency
 
     10:00 am - 1:30 am  Break
 
     10:30 am - 11:10 am Plenary Session
 
                    Hazardous Waste: Impact on Human Health in
                    Europe. H. W. Wyes, World Health Organization
 
     11:15 am - 12:15 Closing Session
 
                    A. Gilman, Health Canada.
 
     12:15 - 12:45       Wrap-Up
 
                    J.S. Andrews, Agency for Toxic Substances and
                    Disease Registry
 
                    H. Frumkin, Emory University
 
     12:45               Adjourn
 
 
 
    ------------------------------------------------------------------------
 
 
[Image] ATSDR Home Page
 
    ------------------------------------------------------------------------
 
Charlie Xintaras / [log in to unmask]
 
 
<<<<<< Attached TEXT file named "mutant gene" follows >>>>>>
A novel cytochrome P-450IID6 mutant gene associated with Parkinson's
disease.
 
Tsuneoka Y; Matsuo Y; Iwahashi K; Takeuchi H; Ichikawa Y
 
Department of Biochemistry, Kagawa Medical School.
 
J Biochem (Tokyo) 114: 263-6 (1993)
 
Abstract
Genetic polymorphism of the CYP2D6 gene [phenotypically individuals are
either poor metabolizers (PM) or extensive metabolizers (EM)] has been
reported to be associated with susceptibility to Parkinson's disease. We
analyzed CYP2D6 genes from Japanese patients and controls, and found that
EM/PM polymorphism is not a suitable marker for populations with a low PM
frequency. However, a novel mutant highly associated with Parkinson's
disease was discovered. The mutation was located at the HhaI site in exon 6
and changed a conserved amino acid residue, Arg296, to Cys296. The risk
factor for the mutant homozygote was 5.56 (95% CI, 1.30-23.82). These
results suggest that the HhaI polymorphism in the CYP2D6 gene is a part of
the molecular basis of Parkinson's disease.
 
Mesh Headings
 
     Arginine
     Base Sequence
     Cysteine
     Cytochrome P-450*
     Deoxyribonucleases, Type II Site-Specific
     Genotype
     Homozygote
     Human
     Hydroxylases*
     Japan
     Molecular Sequence Data
     Mutation
     Parkinson Disease*
     Polymerase Chain Reaction
     Restriction Fragment Length Polymorphisms
 
Unique Identifier: 94086475
 
Gene Symbols
 
     CYP2D6
 
Chemical Identifiers (Names)
 
     EC 1.14. (Hydroxylases)
     EC 1.14.99.- (debrisoquine 4-hydroxylase)
     EC 3.1.21.- (endodeoxyribonuclease HhaI)
     EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
     4371-52-2 (Cysteine)
     7004-12-8 (Arginine)
     9035-51-2 (Cytochrome P-450)
 
 
<<<<<< Attached TEXT file named "platelet mtDNA" follows >>>>>>
PCR analysis of platelet mtDNA: lack of specific changes in Parkinson's
disease.
 
Sandy MS; Langston JW; Smith MT; Di Monte DA
 
California Parkinson's Foundation, San Jose 95128.
 
Mov Disord 8: 74-82 (1993)
 
Abstract
An alteration within the mitochondrial DNA (mtDNA) has been hypothesized to
underlie the deficiencies in mitochondrial complex I activity observed in
the platelets, striatal muscle, and brain tissue of individuals with
Parkinson's disease. Here we utilized the polymerase chain reaction (PCR)
to analyze mtDNA obtained from the platelets of nonmedicated patients with
early Parkinson's disease (n = 8) and aged-matched controls (n = 6) for the
presence of deletion(s) or addition(s) equal to or greater than 50-100 base
pairs. Initial attention was focused upon detecting a 4.977 kb deletion
previously found in the brains of parkinsonian patients and some aged
controls. Indeed, a large deletion of approximately 5.0 kb was observed in
the platelet mtDNA from all parkinsonian individuals. However, this defect
was also found in all age-matched controls as well as in a group of young
healthy subjects (n = 5). In addition, we searched for the presence of
smaller changes in platelet mtDNA from parkinsonian patients by PCR
analysis of four mtDNA segments that code for seven of the complex I
polypeptides. No large deletions or additions were detected within these
four regions of mtDNA in any of the disease or age-matched control samples.
We conclude that (a) a 4.977 kb deletion is apparently present in a
subpopulation of platelet mtDNA from all individuals, and (b) no
macrosequence alteration in mtDNA is likely to underlie the deficiency in
complex I activity reported in platelet mitochondria from parkinsonian
patients.
 
Mesh Headings
 
     Adult
     Aged
     Base Sequence
     Blood Platelets*
     Chromosome Deletion
     DNA, Mitochondrial*
     Gene Amplification
     Human
     Male
     Middle Age
     NAD(P)H Dehydrogenase (Quinone)
     Parkinson Disease*
     Polymerase Chain Reaction*
     Support, Non-U.S. Gov't
 
Unique Identifier: 93125606
 
Chemical Identifiers (Names)
 
     EC 1.6.99.2 (NAD(P)H Dehydrogenase (Quinone))
     (DNA, Mitochondrial)