Another FYI about a meeting of possible interest.


Wendy T.

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Date: 96-11-18 17:02:27 EST

[Federal Register: November 18, 1996 (Volume 61, Number 223)]
[Notices]
[Page 58698-58699]
>From the Federal Register Online via GPO Access [wais.access.gpo.gov]

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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institute of Environmental Health Sciences; National
Toxicology Program (NTP) Board of Scientific Counselors' Meeting;
Review of Draft NTP Technical Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next
meeting of the NTP Board of Scientific Counselors' Technical Reports
Review Subcommittee on December 11 and 12, 1996, in the Conference
Center, Building 101, South Campus, National Institute of Environmental
Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park,
North Carolina. The meeting will begin at 8:30 a.m. both days and is
open to the public. The agenda topic is the peer review of draft
Technical Reports of long-term toxicology and carcinogenesis studies
from the National Toxicology Program.
    Tentatively scheduled to be peer reviewed on December 11-12 are
draft Technical Reports of 10 two-year studies, listed alphabetically,
along with supporting information in the attached table. All studies
were done using Fischer 344 rats and B6C3F<INF>1 mice. The order of
review is given in the far right column of the table. Copies of the
draft Reports may be obtained, as available, from: Central Data
Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709
(919/541-3419).
    Persons wanting to make a formal presentation regarding a
particular Technical Report must notify the Executive Secretary by
telephone, by FAX, or by mail no later than December 6, 1996, and
provide a written copy in advance of the meeting so copies can be made
and distributed to all Subcommittee members and staff and make
available at the meeting for attendees. Written statements should
supplement and may expand on the oral presentation. Oral presentations
should be limited to no more than five minutes.
    The program would welcome receiving toxicology and carcinogenesis
information from completed, ongoing, or planned studies by others, as
well as current production data, human exposure information, and use
patterns for any of the chemicals listed in this announcement. Please
contact Central Data Management at the address given above, and they
will relay the information to the appropriate staff scientist.
    The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233,
Research Triangle Park, North Carolina 27709 (telephone 919/541-3971;
FAX 919/541-0295) will furnish agenda and a roster of Subcommittee
members prior to the meeting. Summary minutes subsequent to the meeting
will be available upon request to Central Data Management.

    Dated: November 11, 1996.
Kenneth Olden,
Director, National Toxicology Program.

  Summary Data for Technical Reports Tentatively Scheduled for Review at
the Meeting of the Board of Scientific
                     Counselor's Technical Reports Review Subcommittee,
December 11-12, 1996
------------------------------------------------------------------------------
----------------------------------
                                      Technical
report                            Route exposure        Review
         Chemical CAS No.                   No.              Primary
uses             levels            order
------------------------------------------------------------------------------
----------------------------------
3'-AZIDO-3'-deoxythymidine (AZT)    TR-469
Pyrimidine            Gavage 5%                       2
 30516-87-1 and.                                          nucleoside
analog     Methylcellulose):
                                                          with
antiviral        Mice only: 0, 30,
                                                          activity used
in      60, OR 120 MG/KG;
                                                          the treatment
of      50/SEX.
                                                          AIDS (Merck
1989).
INTERFERON AD+ AZT (AIDS            ...................  Used in
the           Subcutaneous Inj.+
 INITIATIVE).
experimental          Gavage (.5%
                                                          treatment of
AIDS.    Methylcellulose):



DUAL ROUTES WITH



BOTH COMPOUNDS:



AZT: 0, 30, 60, OR



120 (GAV) MG/KG;



IFN: 500 OR 5000



UNITS 3X/WEEK.
CHLOROPRENE 126-99-8..............  TR-467               Monomer for
neoprene  Inhalation (Air):               4

elastomers;           Rats & Mice: 0,
                                                          industrial
rubber     12.8, 32.0, OR 80.0
                                                          products;
component   PPM; 50/SEX/SPECIES/
                                                          of
laboratory         GROUP.
                                                          adhesives in
food

packaging.

[[Page 58699]]





































COBALT SULFATE HEPTAHYDRATE 10026-  TR-471               Drying agent
for      Inhalation (Air):               3
 24-1.                                                    varnishes and
inks;   Rats & Mice; 0,
                                                          component
of          0.3, 1.0, OR 3.0 MG/

electroplating        M3; 50/SEX/SPECIES/

solutions.            GROUP.
ETHLYBENZENE 100-41-4.............  TR-466               Manufacture
of        Inhalation (Air)                6
                                                          synthetic
rubber.     Rats & Mice: 0, 75,
                                                          Solvent.
Fuel         250, 750 PPM (50/
                                                          additive.
Chemical    SEX/SPECIES/GROUP).

intermediate.
ISOBUTYRALDEHYDE 78-84-2..........  TR-472               Synthesis
of          Inhalation (Air)               10
                                                          pantothenic
acid,     Rats & Mice: 0,
                                                          cellulose
esters,     500, 1000, OR 2000
                                                          perfumes,
flavors,    PPM (50/SEX/SPECIES/
                                                          and
gasoline          GROUP).
                                                          additives.
Chemical

intermediate.
OXAZEPAM 604-75-1.................  TR-468
Tranquilizer........  Dosed-Feed (NIH-07):            1



Rats only: 0, 625,



1250, 2500, 5000,



OR 10000 PPM; 50/



SEX/GROUP.
POLYVINYL ALCOHOL 9002-89-5.......  TR-474               PVA film
for          Intravaginal                    8

intravaginal          (Deionized Water):
                                                          administration
of     Mice only: 25% PVA,

spermicides.          VEHICLE, UNTREATED;
                                                          Textile warp
sizing   100/GROUP.
                                                          and
finishing,

adhesives.
                                                          Pesticides.
Pigment
                                                          in TV picture
tubes.
PRIMIDONE (PRIMACLONE) 125-33-7...  TR-476
Prophylactic          Dosed-Feed (NIH-07              9
                                                          management
of         Mice: 0, 0.03,
                                                          partial grand
mal     0.06, OR 0.13% Rats
                                                          and
psychomotor       & Mice: 0, 0.06,
                                                          seizures that
are     0.13, OR 0.25% (50/
                                                          refractory to
other   SEX/SPECIES).
                                                          antiepileptic
drugs.
TETRAHYDROFURAN 109-99-9..........  TR-475               Reaction medium
for   Inhalation (Air)                7
                                                          grignard and
metal    Rats & Mice: 0,
                                                          hydride
reactions.    200, 600, OR 1800

Packaging             PPM (50/SEX/SPECIES/

fabrication.          GROUP).
                                                          Solvent for
resins
                                                          and
plastics.

Chemical

intermediate.
THEOPHYLLINE 58-55-9..............  TR-473               Diuretic,
cardiac     Gavage (Corn Oil):              5
                                                          stimulant,
smooth     Rats: 0, 7.5, 25,
                                                          muscle
relaxant,      OR 75 MG/KG; 50/

antiasthmatic,        GROUP Female Mice:
                                                          occurs
naturally in   0, 7.5, 25, OR 75
                                                          tea (Merck
1989).     MG/KG; 50/GROUP



Male Mice: 0, 15,



50, OR 150 MG/KG;



50/GROUP.
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[FR Doc. 96-29465 Filed 11-15-96; 8:45 am]
BILLING CODE 4140-01-M