On Sat 14 Dec, JON A MEYER wrote:
> Greetings to all
>
> After trying all of the suggestions I got, on when & with what to take
> Sinemet with, I still had problems with nausea and a general weakness
> lasting about 2 hrs. after taking my meds.
> I finally called my neuro Thursday and talked to the nurse (the Dr was
> out that day) and she got a hold of the Dr. and he changed me from
> sinemet 25/100 to 50/200CR.  Low and behold no more nausea or tired
> feeling. The nurse told me that the med was hitting my system all at once
> and that the CR should help. It seems to be controlling my tremors too.
> I also found out that my mother, and my neuro's mother, and my family
> Dr's father all went to college together.
>
> At my last visit the neuro also brought up surgery for in the future.
> His suggestions were Loma Linda University Med Center or Indiana Univ.
> hospital. I'll wait to see how things progress.
>
>
> Jon Meyer 39/1 ([log in to unmask])
> another Hoosier
> (I'm still sticking to the theory of Hoosiers coming from "who's yar")
>
Hello Jon. I read your post on changing to Sinemet CR tablets with great
interest, as I was diagnosed as having PD at the age of 39. (That's 17 years
ago).
   You say that the nausea and weakness lasted about 2 hours after taking the
old tablets: 2 hours is about the duration of effectiveness of the 25/100
tablet, in most people. Similarly, the CR tablets have a typical duration of
4 hours, or 50 mg/hr, so on the face of it, nothing much has changed. I am
inclined to agree with the nurse, that somehow you were taking the Sinemet
on board too quickly; this was throwing you into an overdose condition, which
could quite easily last two hours. How frequently were you taking the 25/100
tablets, and how frequently do you take the CR tablets?
   Another rather strange item is the overdose symptoms that resulted. I have
to continually remind myself that we all differ in various ways in our response
to PD and the meds which we take for it.
   I had no idea where my musings would lead when I started writing this email.
In the end, I feel that I have contributed very little, but I'll post it
anyway, and if you have any developments perhaps you will keep us informed.

I must comment on the mention of surgery: To someone as young as you it seems
to me that surgery should be the last thing on your mind. Even though it was
mentioned for 'in the future' I still find it strange. I won't go into it in
detail at this point, but let's say that I consider it as a last resort, and
I'm not there yet.

I wish you the best of luck,
Regards,
--
Brian Collins  <[log in to unmask]>