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         11-Dec-96 Recognizing Nonmotor "Off" Symptoms In Parkinson's
         Patients: Way To Avoid  Unnecessary Treatments


     Recognizing Nonmotor "Off" Symptoms In Parkinson's Patients: Way
     To Avoid Unnecessary Treatments

     WESTPORT, Dec 11 (Reuters) - Recognition of nonmotor "off"
     phenomena in Parkinson's disease patients can prevent unnecessary
     tests and treatments, two researchers at the University of
     Medicine and Dentistry of New Jersey, New Brunswick, report.

     Drs. Jacob I. Sage and Machteld E. Hillen studied 130 patients
     with Parkinson's disease and motor fluctuations.

     Dr. Sage told Reuters Health: "Most physicians who think of
     fluctuations in Parkinson's disease patients think of motor
     fluctuations. An important thing to realize is that there are
     nonmotor fluctuations that may be just as disabling. This is not
     an uncommon problem. Among patients who have motor fluctuations,
     17% have nonmotor fluctuations, as well, [such as]
     cognitive/psychiatric dysfunction, sensory symptoms and autonomic
     dysfunction, which can occur as end-of-dose phenomena."

     More specifically, nonmotor "off" states, according to Drs. Sage
     and Hillen, are manifested as "...sensory dyspnea, nausea, facial
     flushing, cough, hunger, unilateral limb edema, proximal limb
     pain, and trigeminal neuralgia-like pain."

     The authors recommend diminishing the amount of "off" time as
     much as possible. To that end, "...[a]dding a dopamine agonist,
     using controlled-release preparations of [levodopa], or
     increasing the frequency of dopaminergic medication may be
     helpful [in] some of these patients."

     Neurology 1996;47:1180-1183.

     -Westport Newsroom 203 221 7648


     Previous | Next | Back to Medical News



Copyright c 1996 Reuters Limited.

Other stories show are:


05-Dec-96 Amgen, Neurogen Outline Product Developments

27-Nov-96 Genentech, CytoTherapeutics To Collaborate On CNS Diseases

 21-Nov-96 Lundbeck, Centaur In Parkinson's Drug  Collaboration

 20-Nov-96 Olfactory Pathways Create 'Odor  Images'

19-Nov-96 Vertex Compound Accelerates Nerve  Regeneration In Rat Model

15-Nov-96 Parkinson's Gene Region  Located

15-Nov-96 Scientists Map Location Of Gene For  Parkinson's Disease

22-Oct-96 Neural Control Of Initiation Of  Voluntary Movement Described

17-Oct-96 Gene Defect Linked To  Parkinson's

16-Oct-96 Pallidotomy Effective For Intractable  Parkinson's Disease

15-Oct-96 Early Diagnosis Of Lyme  Meningitis: Highlight Of American Neurological
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11-Oct-96 Cellular Defect In Parkinson's Disease Linked To  Mitochondrial Mutation

03-Oct-96 Styrene Danger To Plastics Workers

03-Oct-96 FDA Approves Schizophrenia Drug

02-Oct-96  FDA Clears New Schizophrenia Drug

 01-Oct-96 Senate Approves  Reauthorization Of NIH For One Year

 01-Oct-96  Interferon-Alpha: Cost-Effective Treatment For Chronic
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30-Sep-96 Senate Approves NIH Reauthorization Bill

30-Sep-96 Reversible Parkinsonism Associated With Chronic Valproate Use

27-Sep-96 Genzyme Tissue Repair And Diacrin Form Joint Venture

27-Sep-96  Pallidotomy Improves Symptoms Of Advanced Parkinson's Disease

25-Sep-96 Pharmacia And Upjohn To Study Parkinson's  Specifically In Minorities

24-Sep-96 Possible Role For Diet  In Parkinson's Disease

20-Sep-96 Sugar, Wine Link To Parkinson's Disease

09-Sep-96 Prophylaxis For Respiratory  Syncytial Virus Is Cost Effective

09-Sep-96 "Deep Brain  Stimulation" Stops Parkinson's Tremors

09-Sep-96 Color-Blind Men May Not Recognize Rectal Bleeding

06-Sep-96 Pacemaker  Boon To Heart Beat

06-Sep-96 Pacemaker Boon To Heart Beat

06-Sep-96 Antioxidant Clue To Parkinson's Disease

06-Sep-96 Antioxidant Clue To Parkinson's Disease

06-Sep-96 Men Can Be  Bulimics Too

06-Sep-96 Men Can Be Bulimics Too

03-Sep-96  California Senate Makes Theft Of Human Embryos A Crime

03-Sep-96 High Uric Acid Levels May Lower Risk Of Idiopathic Parkinson's Disease

03-Sep-96 Long-Term Selenium Intake Linked To Amyotrophic Lateral Sclerosis

30-Aug-96 Animal Transplants Get Support

16-Aug-96 Estrogen Therapy May Reduce  Risk Of Alzheimer's Disease

08-Aug-96 Somerset Files Suit  Against The FDA

07-Aug-96 Susceptibility To Parkinson's Disease Is Higher In First-Degree Relatives

18-Jul-96 Senate  Committee Unanimously Approves NIH Reauthorization Bill

27-Jun-96 Neurotrophic Factor Encodes Proto-Oncogene:  Implications For Parkinson's
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27-Jun-96 Bill Calls For Increased Spending On Parkinson's  Disease Research

25-Jun-96 Number Of Biotechnology Drugs In  Development Increases 21% In One Year

24-Jun-96  Radiofrequency Ablation Effective In Children With  Tachyarrhythmias

20-Jun-96 New Regimen Improves Functionality  Of Parkinson Disease Patients

14-Jun-96 Postmenopausal  Estrogen Therapy Stimulates Cerebral Blood Flow

12-Jun-96  Amersham Says Myoview Launch Begins Well

12-Jun-96 Close To  30% Of Parkinson's Disease Patients Have Dementia

11-Jun-96  New Agent For Monitoring Brain Tissue in Parkinson's
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31-May-96 Long-Term Effects of Methamphetamine Abuse In  Humans Elucidated

30-May-96 Tangled Research Integrity Case May Be Nearing A Close

14-May-96 In Vitro Test For Alzheimer's Disease: Accurate In Preliminary Trial

13-May-96 Titan Pharmaceuticals Subsidiary Signs Licensing Agreement

13-May-96 Metronome Helps Parkinson's Disease Patients Walk   Better

06-May-96 Pharmacia & Upjohn, Amylin Report Results

17-Apr-96 SIBIA Neurosciences And Salk Institute Sign License  Agreement

11-Apr-96 Amgen To Seek FDA Approval For Three  Drugs

04-Apr-96 Stress Alters Immune Response To Flu Vaccination

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22-Mar-96 Neurotrophic Factor Eases Parkinson Symptoms In  Monkeys

20-Mar-96 Diacrin, Inc., Somanetics Announce First  Quarter Results

20-Mar-96 Association Between Parkinsonian  Disorder And REM Sleep Behavior Disorder
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20-Mar-96 Ocular Abnormalities Detect CNS Dysfunction In  HIV-Positive Patients

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22-Feb-96  Inhibition Of Monoamine Oxidase B Involved In Development Of
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19-Feb-96 PathoGenesis, Guilford Pharmaceuticals Report  Results

16-Feb-96 Dopamine Transporter Protein Essential for  Amphetamine's Psychoactivity

16-Feb-96 Deprenyl Slows  Disability In Early Parkinson Disease, But Effect Not
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14-Feb-96 Internal Clock Regulated By Dopamine;  Violence Uncommon In Patients With
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09-Feb-96 Gluten Sensitivity, Neurological Disorders And  Celiac Disease: A Possible Link

26-Jan-96 Music Therapy:  Gaining Interest And Acceptance...Slowly

18-Jan-96  Bristol-Myers And NeuroSearch In Pact

17-Jan-96 Alzheimer  Disease: A Correct Diagnosis At Least 88% Of The Time

11-Jan-96 More Than Half Of Persons Over 65 Years Of Age Have
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09-Jan-96 Risk Of Dementia High In Parkinson  Disease Patients And Low In Epilepsy and
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15-Dec-95 Combination Selegiline/Levodopa For Treatment Of  Parkinson's Under Fire

14-Dec-95 Metoclopramide Use Increases One's Chances Of Levodopa Treatment

11-Dec-95 Deprenyl  Neuroprotective In Patients With Parkinson's Disease


 30-Nov-95 Warner-Lambert Fined 10 Million For Shipping Potentially Defective Drugs

28-Nov-95 Pharmacia & Upjohn To Launch Several Drugs

24-Nov-95 Surgery Relieves Some Symptoms  Of Advanced Parkinson's Disease

07-Nov-95 Fluoxetine May Relieve Levodopa-Induced Dyskinesias

Copyright c 1996 Reuters Limited.








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