> Aan 13-01-97 5:48, in bericht
> <[log in to unmask], elizabeth
> leslie <[log in to unmask]> schreef:
>
> > Hello Ida (if I may call you that)
> >
> >
> > On Sat, 11 Jan 1997, you wrote:
> >
> > > The question of Marge is not fully answered, I think
> > > The question is not about PWP's having schizophrenia or vice versa, but
> > about
> > > the phenomenon that the l-dopa used by PWP's can cause some symptoms that
> > are
> > > similar to some symptoms of schizophrenia (hallucinations and
> confusion)and
> > > vice versa psycholeptica indicated for schizophrenia can not cause PD, but
> > > symptoms who are like PD symptoms: bradykinesia, dyskinesia.
> > > Does it make sense to say that the med's for both diseases don't arrrive
> > only
> > > in the disturbed place of the brain, but unfortunately as much in
> > undisturbed
> > > places.
> >
> >
> > > The l-dopa used by PWP's causes to high a level of dopamine in the "schiz
> > part"
> > > of the brain giving "schiz." symptoms. The psycholeptica arriving
> > unfortunately
> > > in the extra-pyramidal system too, causing in that region a shortage of
> > > dopamine and hence Parkinson like symptoms.
> >
> >
> > I wonder if you'd say more to me about the 'extra-pyramidal system' - my
> > neuro has used this term but i have very little understanding of what it
> > really means.  And it is obviously part of the reason why he has not
> > commenced me on l-dopa yet.  Which frightens me more than a little.\
> >
> > What is psycholeptica?
> >
> >
> > > The question now is whether this symmetry is in any way indicative of a
> > > relationship between these diseases.
> > > I asked myself something else. Some time ago PWP's  suffering from light
> > > intolerance was a topic on the list. Can this be caused by to a high
> level
> > of
> > > dopamine in the retina.
> >
> >
> > Strangely, I have just this last week or so begunto notice some light
> > intolerance that is new to me, too.
> >
> >
> > I hope this is not an intrusion. But I always read your mails with interest.
> >
> > Regards
> >
> > Beth Leslie
> >
> Dear Beth
>
> Of course you do not intrude. E-mail in general is not intruding as telephone
> can be. Besides I like always to hear (read ) that anyone has seen what I
> wrote. So you are very welcome.
> Parkinson's disease is a disturbance of the extra pyramidal system. Our
> movements are regulated by two systems the pyramidal and the extra=pyramidal.
> The first regulates the whole movent that we can consciously regulate with
> our
> will. The second has the task of fine tuning of our movents. Movements are
> initiated in the upper part of the pyramidal system. So when one is standing
> and decides to lift ones arm, this decision causes activity in some place
> high
> in the brain which is part of the pyramidal system. To do the lifting however
> is a very complex because it disturbs your equilibrium and in some way one
> has
> to compensate for that. One doesn't need to know all de muscles in your arm
> who
> all work together, to make the movement,and at the same time keep one
> upright.
> Our consciousness does not meddle with these things. A part of the extra
> piramidal system coordinates movement with vision; by this we are able to
> take
> a pen from the table steering our hand exactly to the right place. That part
> is
> in PWP's undisturbed.
> But the other task, the coordination of movements themselves, that is were PD
> does his harmfull work.
> If your neuro. says you have a disturbed extra-piramidal system, that is
> nothing to be scared about. PD is the most frequent extra-pyramidal disease.
> The most probable reason for not giving you l=dopa what I think is that he
> thinks your disease is not yet that worse. Some neuro's think it is better to
> postpone the l-dopa as long as possible.
> Now the psycholeptica. Psycholeptica are sometimes called major
> tranquilizers.
> They are used by people who are psychotic, who are not able to see reality in
> an ordinary way, Have hallucinations or hear voices.
> The medicines against these symptoms had in the past parkinson like symptoms
> as side effect. Nowadays this is less so.
> I hope I answered your questions. If you want to know more feel free to ask.
>
> I recognised much in what you told about the neuro who couldn't stand crying.
> I was some time hospitalised to be diagnosed. I did have a tough time before
>
> knowig I was ill but not what it was. I had to hold myself together for the
> children. So being in a hospital I diminished control. All people reactred by
> trying to let me stop. It was not possible to let me simple cry,because I had
> reason to.
>                                    Ida Kamphuis
>                                             Holland
>