=46rom: Linda Carlton <[log in to unmask]>
To: [log in to unmask]
Subject:
 http://207.155.63.2/medscape/cgi-bin/taos_doc.pl?msw+0+med96-97+2142=
91+query+(reduced-glutathione)
Date: Tue, 25 Mar 1997 02:44:37 -0800

[ Search and Display Medscape Full-Text Articles ]

Please use your Browser's 'BACK' button to return to the listing

 Title: Oxidative stress and Parkinson's disease.
 Title Abreviation: Ann N Y Acad Sci             Date of Pub: 1996 Ju=
n 15
 Author: Owen AD; Schapira AH; Jenner P; Marsden CD;
 Issue/Part/Supplement:          Volume Issue:
 -HEADING-                       786              Pagination: 217-23
 MESH Headings: Animal; Cell Death*; Glutathione*; Human; Iron*; Oxid=
ative
 Stress*; Parkinson Disease*; Rats*; Substantia Nigra*; Support, Non-=
U.S.
 Gov't; -PG-;
 Journal Title Code: 5NM         Publication Type: JOURNAL ARTICLE
 Date of Entry: 960819N          Entry Month: 9610
 Country: UNITED STATES          Index Priority: 2
 Language: Eng                   Unique Identifier: 96280968
 Unique Identifier: 96280968     ISSN: 0077-8923
 Abstract: The underlying mechanism of cell death in substantia nigra=
 of
 Parkinson's disease patients remains unknown. Biochemical changes
 occurring in substantia nigra in Parkinson's disease (increased iron
 levels, inhibition of complex I activity and decreased reduced gluta=
thione
 levels; GSH) suggest that oxidative stress and free radical species =
may be
 involved. In particular, a decrease in GSH levels may be an early
 component of the process, since this also occurs in incidental Lewy =
body
 disease (presymptomatic Parkinson's disease). GSH is lost only from =
the
 substantia nigra in Parkinson's disease and this does not occur in o=
ther
 neurodegenerative disorders of the basal ganglia. GSH loss appears t=
o be
 global throughout the substantia nigra and not localized to either t=
he
 glia or neuronal elements. The activity of enzymes involved in the
 glutathione cycle are normal with the exception of
 gamma-glutamyltranspeptidase, the activity of which is increased. Th=
is
 could result in increased removal and degradation of glutathione fro=
m
 cells. Depletion of GSH in rat using L-buthionine-=CDS, R=CD-sulfoxa=
mine (BSO)
 potentiates 6-hydroxydopamine (6-OHDA) toxicity but does not in itse=
lf
 produce degeneration of the nigrostriatal pathway. Oxidative stress =
may be
 a potentially important factor in the degeneration of the substantia=
 nigra
 in Parkinson's disease and warrants further investigation into its r=
ole in
 this process.
 Abstract By: Author
 Address: Neurodegenerative Diseases Research Centre, King's College
 London, United Kingdom.