Title: Intrastriatal taurine increases striatal extracellular dopami=
ne in
 a tetrodotoxin-sensitive manner in rats.
 Title Abbreviation: Neurosci Lett     Date of Pub: 1996 Jul 19
 Author: Ruotsalainen M; Ahtee L;

 Issue/Part/Supplement: 3  Volume       Pagination: 175-8
                           Issue: 212
 MESH Headings: Animal; Corpus Striatum*; Dopamine*; Injections, Spin=
al*;
 Male; Rats*; Rats, Wistar*; Support, Non-U.S. Gov't; Taurine*;
 Tetrodotoxin*; 3,4-Dihydroxyphenylacetic Acid*; -PG-;
 Journal Title Code: N7N   Publication Type: JOURNAL ARTICLE
 Date of Entry: 970106N    Entry Month: 9703
 Country: IRELAND          Index Priority: 2
 Language: Eng             Unique Identifier: 96440790
 Unique Identifier:
 96440790                  ISSN: 0304-3940
 Abstract: In vivo effects of locally administered taurine on striata=
l
 dopamine release and metabolism were studied by microdialysis in fre=
ely
 moving rats. Concentrations of dopamine, 3,4-dihydroxyphenylacetic a=
cid
 (DOPAC) and homovanillic acid (HVA) in striatal dialysates were quan=
tified
 by high pressure liquid chromatography (HPLC) using electrochemical
 detection. Infusion of 150 mM taurine into the striatum for 2 h indu=
ced a
 2.5-fold increase in the extracellular dopamine concentration.
 Extracellular DOPAC concentration increased nearly 2-fold. Taurine
 infusion initially decreased HVA to 70% but afterwards increased it =
to
 140% of the control. When taurine was infused simultaneously with 1 =
microM
 tetrodotoxin starting 60 min after tetrodotoxin, the output of dopam=
ine
 did not differ from that in the presence of tetrodotoxin alone.
 Tetrodotoxin abolished the effects of taurine on dopamine metabolite=
s as
 well. Tetrodotoxin-sensitivity of the effects of taurine on dopamine=
 and
 its metabolites suggests that intrastriatal taurine elevates extrace=
llular
 dopamine by releasing it from neuronal pool.
 Abstract By: Author
 Address: Department of Pharmacy, University of Helsinki, Finland.
 [log in to unmask]

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