------ =_NextPart_000_01BCC385.442567A0
Content-Type: text/plain; charset="us-ascii"
Content-Transfer-Encoding: quoted-printable

I'm very glad that I can to help you.
How I wrote last week , In Argentine in this moment is The XVIth World =
Congress of Neurology.
Today, it was the presentation about Tasmar.
There was an interesting lecture (COMT Inhibition: Overview of clinical =
data with Tolcapone in non- fluctuating and fluctuating Parkinson's =
disease patients. Wolfgang Oertel Philips-University, Marburg, Germany)
In this lecture the speaker said that:
"Long-term clinical trials with Tolcapone, a new COMT inhibitor, have =
demonstrated clinically significant improvements in symptom control and =
ON-time, as well as good  tolerability, when used as an adjunct to =
levodopa/DCI in both non-fluctuating and fluctuating PD patients. Four =
double-blind, placebo-controlled trials and one open-label =
active-controlled trial have evaluated orally administrered tolcapone =
(100mg tid and 200 mg tid) for up to 12 months in over 1000 PD patients =
(298 non-fluctuating, 740 fluctuators). The majority of adverse events =
observed were dopaminergic in nature, being attributable to an increase =
in the bioavailability of levodopa. The most frequent dopaminergic =
adverse event was dyskinesia on initiation of tolcapone therapy =
especially in patients who had previously experienced (peak dose) =
dyskinesia and/or received at baseline a daily levodopa dose larger that =
600 mg. However, this side effect was controlled in most patients by =
rapid levodopa adjustment. The most severe non-dopaminergic adverse =
event attributable to tolcapone was diarrhoea, whic led to withdrawal in =
5% and 6% of patients receiving tolcapone 100mg tid and 200mg tid, =
respectively, compared with 1%  receiving placebo."


Beside this, I want to say to you that the Tasmar is being sold in =
argentine from yesterday. The cost is U$S 78 100mg  (30 Pills) (for 10 =
days because three pills for day) up to US 185 200mg (60 pills).
I wait that this information is very useful for you.
PD: In the message previous I had not any attachment, I don't understand =
what happen.
Elizabeth Ojeda
eagle @pccp.com.ar


------ =_NextPart_000_01BCC385.442567A0
Content-Type: application/ms-tnef
Content-Transfer-Encoding: base64

eJ8+IgATAQaQCAAEAAAAAAABAAEAAQeQBgAIAAAA5AQAAAAAAADoAAEIgAcAGAAAAElQTS5NaWNy
b3NvZnQgTWFpbC5Ob3RlADEIAQ2ABAACAAAAAgACAAEEkAYA+AEAAAEAAAAQAAAAAwAAMAMAAAAL
AA8OAAAAAAIB/w8BAAAAXAAAAAAAAACBKx+kvqMQGZ1uAN0BD1QCAAAAAFBhcmtpbnNvbidzIElu
Zm9ybWF0aW9uIEV4Y2hhbmdlAFNNVFAAUEFSS0lOU05AbGlzdHNlcnYudXRvcm9udG8uY2EAHgAC
MAEAAAAFAAAAU01UUAAAAAAeAAMwAQAAAB4AAABQQVJLSU5TTkBsaXN0c2Vydi51dG9yb250by5j
YQAAAAMAFQwBAAAAAwD+DwYAAAAeAAEwAQAAACMAAAAnUGFya2luc29uJ3MgSW5mb3JtYXRpb24g
RXhjaGFuZ2UnAAACAQswAQAAACMAAABTTVRQOlBBUktJTlNOQExJU1RTRVJWLlVUT1JPTlRPLkNB
AAADAAA5AAAAAAsAQDoBAAAAHgD2XwEAAAAhAAAAUGFya2luc29uJ3MgSW5mb3JtYXRpb24gRXhj
aGFuZ2UAAAAAAgH3XwEAAABcAAAAAAAAAIErH6S+oxAZnW4A3QEPVAIAAAAAUGFya2luc29uJ3Mg
SW5mb3JtYXRpb24gRXhjaGFuZ2UAU01UUABQQVJLSU5TTkBsaXN0c2Vydi51dG9yb250by5jYQAD
AP1fAQAAAAMA/18AAAAAAgH2DwEAAAAEAAAAAAAAA4d2AQSAAQA1AAAAQ29udGludWUgdGhlIGlu
Zm9ybWF0aW9uIGFib3V0IFRhc21hciBmcm9tIEFyZ2VudGluZQDAEwEFgAMADgAAAM0HCQARABAA
EAA7AAMATAEBIIADAA4AAADNBwkAEQAQABAAOwADAEwBAQmAAQAhAAAANUE3MDc0OTg3MjJGRDEx
MUFGNjk0NDQ1NTM1NDAwMDAAyQYBA5AGACQJAAAhAAAACwACAAEAAAALACMAAAAAAAMAJgAAAAAA
CwApAAAAAAADADYAAAAAAEAAOQAAwTNFnsO8AR4AUAABAAAAAQAAAAAAAAAeAHAAAQAAADUAAABD
b250aW51ZSB0aGUgaW5mb3JtYXRpb24gYWJvdXQgVGFzbWFyIGZyb20gQXJnZW50aW5lAAAAAAIB
cQABAAAAFgAAAAG8w54KX5h0cGovchHRr2lERVNUAAAAAB4AHgwBAAAABQAAAFNNVFAAAAAAHgAf
DAEAAAASAAAAZWFnbGVAcGNjcC5jb20uYXIAAAADAAYQWJ/degMABxCfBgAAHgAIEAEAAABlAAAA
SU1WRVJZR0xBRFRIQVRJQ0FOVE9IRUxQWU9VSE9XSVdST1RFTEFTVFdFRUssSU5BUkdFTlRJTkVJ
TlRISVNNT01FTlRJU1RIRVhWSVRIV09STERDT05HUkVTU09GTkVVUk9MTwAAAAACAQkQAQAAAOgF
AADkBQAApQgAAExaRnVc20wBAwAKAHJjcGcxMjU2MgD4C2BuDhAOIDc0nQH3IAKkA+MCAGNoCsBg
c2V0MCAHEwKAfTkKgXVjAFALAwu1IEkQJ20gdgSQeSBnMQtgZCB0ERAFQEkgAmMDkXRvIGhlbGhw
IHkIYC4KogqASBZvB+AUgHcDYHRlIBULYHMFQHcJ4GsgLNcTQAOgBxBnCfB0C4AWoPcLgBQhBAAg
BGAHgAIwGECFBCBUFRAgWFZJFDD0IFcFsGwUEAhQDyAJcDkEEW9mB7EIcAjxZ3mlFZVUBHBheRdg
aRbxdxbQFCEWoHAasRfhFFBp3QIgIAGgCGAFQFQW0ADA/nIbxhUQCXAcwwORC4AWkNsasRgBZxaw
BZB0CHAWoGAoQ09NVBdxGJBioxygHeE6IE8TkXYIkHMH4BsBY2wLgA3gB0AgvxxQAZAWUBygGfAc
MGwUoJZwAiAYM24CIC0gDvB/EkAhEB3BILEAcBQQJZpQVQrAawuAcwIgJwQgZD0EAGUW0B0xHcEX
4XMu8RoBbGZnDxEicASQFpANAyBQGJAjUHBzLVVXAwATkQCQdBxxTQrAYjUIcGcXYEcEkAOBeSmf
FaQXgRiDIOYdEnNwKEBeawSQLhALcBQUOhWkIrpMGoEtIEETcCNHdAci/wQgJCwXYCQAGCAH4CFz
C4C/IeMFsBdgERATkCPAZQRg3wCAMOAUUAmAIzdsE8AAkFpnAwBmI4EZEm0dUG/vE5AY8gQgGFFz
BsAFMANwzxSQAiEbYSZDT04v8AdxnzIxMTEVIDghBCBnbwRwfiAU0SDgNHAiACNQKzJ3exUQA6B1
EUAUEB/EFABqXHVuIQAU0iDgdgRwb/EKsC9EQxSAGFEG4Bnh1yVCJZ8mqkQoiUYIYSPAswhgAmBl
LQJgC4BkF2DpC1FjZQbgLTfFIOAUEV8w9D8CJNI9AAnwLQtgYv8qAQDQGAATkEJ/M6Q8wAdA3z6R
NKEFsDUzFABtI2E0UQcfcRQRJIcoMTAwbX8gwBgAO4EmYQHQEXBJdCn7JYAFsXUVQBThDiAYwQIw
/mg28zaBBcBJQRFwQAkhUPgyOTg9/hdgD3ARcD5GuQWwcykpEBlyAMBqBbA/KyEa8hQAKuJGgjbD
b2L/EUAisDShFxAfgTzyR9EEkP5nDeAlAxRQISEXYESQPsP/AkAFECugAZEg4BTSH/MFAO8oQxhT
FqAiAG8zwAtwRHFvOpMa8jy2UBVvFuEDUGU+cQpQGRFTC1E7HMNkef5zJ4EHkAcwQ9EYQSIRHcTv
GwFImB0RNHBwE8AHkC4w/mMHMTVRGFFNJzsAFPEUAZcdUSLACGBzNVFleC4w9wiBPEA0oSguMkER
EUBKwPtb+T8BLwWxCXBCMCrRO4H9BUBiKFEjURagJAAcUAMQfxPAPLZigxaxF8EFwBQzNv9KMykQ
FgFRsTOBGIMAkAEA/0aQASAg8RzDQokYUVkjTSf+YhPAXoEuwWXnPAIW4Bjy/1jJEUATkRagJUJa
D1sYVO7nSJhbswcwcnJgUChAOuLvU6FC8xTwJCJkNHAc0AMg6RhRNSU+8zZ0sBsBTSf/ZBQgokiY
SU9JdBdgGrFe8f9E8jVQF2AFoDZQCsBSgiQyzjF0sHX5QgUuIhWkfAr+QlxRaQEYghdhHMEZERTh
/y6gE8AU4RVhFCQdEh6EGTL/VIQnsBpBGFFm0hf0A1IVUH8gcQSQHFFQFAWgFuEYoVW6JAXwN03g
d0QhUDNM0fcDEDEgSsAoSuJ3QCPBXAD/VHEUoDtRFCEJ0R1AhOJK0xccUUrASyRVBfAxODX9eBUo
Z4CG5FAALIUcwRyh/39FGKELgErhAMAd0xihE5P5O1FmdQMgSuIVaEAAImD3LONQURrBYRfQYLcU
cWCC3yVAcFEsUHBiANBoGPJ90v888CfQBUA8MASBFuA/AjsAWxRRERBwRDEVlUUjUHrTRIEZ4U9q
CYBhFaQoQKMT4BagQHBjDfAuebFWLgrAfA8KEgEAl0ADABAQAAAAAAMAERAAAAAAAwCAEP////9A
AAcw4IFCLJnDvAFAAAgwAMEzRZ7DvAELAACACCAGAAAAAADAAAAAAAAARgAAAAADhQAAAAAAAAMA
AoAIIAYAAAAAAMAAAAAAAABGAAAAABCFAAAAAAAAAwAFgAggBgAAAAAAwAAAAAAAAEYAAAAAUoUA
ALcNAAAeACWACCAGAAAAAADAAAAAAAAARgAAAABUhQAAAQAAAAQAAAA4LjAAAwAmgAggBgAAAAAA
wAAAAAAAAEYAAAAAAYUAAAAAAAALAC+ACCAGAAAAAADAAAAAAAAARgAAAAAOhQAAAAAAAAMAMIAI
IAYAAAAAAMAAAAAAAABGAAAAABGFAAAAAAAAAwAygAggBgAAAAAAwAAAAAAAAEYAAAAAGIUAAAAA
AAAeAEGACCAGAAAAAADAAAAAAAAARgAAAAA2hQAAAQAAAAEAAAAAAAAAHgBCgAggBgAAAAAAwAAA
AAAAAEYAAAAAN4UAAAEAAAABAAAAAAAAAB4AQ4AIIAYAAAAAAMAAAAAAAABGAAAAADiFAAABAAAA
AQAAAAAAAAAeAD0AAQAAAAEAAAAAAAAAAwANNP03AACDZA==

------ =_NextPart_000_01BCC385.442567A0--