Hey Dale Severance, you wrote:

>                          November 22, 1997
>
>I have just taken my first pill of requip. My physician participated in the
>clinical trials of this drug at the PDF in NY City and placed me on a
>different schedule than that which is recommended by the manuf.

Your doc. seems to know his Requip. I took the standard manufacturer's
starter pack, but seemed to be getting no benefit! So I increased the
dose fairly quickly up to 20 mg per day, and it cut in nicely.

However, I started to experience hypersensitivity, of skin and hearing,
so I cut back to 15 mg per day, which suits me very well, along with
Madopar (Levodopa + benserazide), 1250 mg per day.

Keep well.
Jeremy
>
>Prior to today I was taking sinemet 25/100 every three hours, elderpril 5mg
>morning and lunch and parlodel 5mg four times a day.
>I am experiencing increasing tremours in my left hand, foot curling in  with
>toes curling under and end of doze movement.
>
>In the past I have had no difficulty getting started with new meds and I am
>fornunate that I am in my 11 year without experienceing any depression.
>
>Against that back ground we have decided to increase by .25mg the requip
>every 2 days instead of ever 7 days as recommended by the manuf. The doctors
>reasoning was that requip has some of the properties of parlodel which I have
>had no problem with in the past. I also discontinued parlodel immediately or
>cold turkey without and phaseing off period.
>
>I have a real good relationship with Dr. Efraim Perez a movement disorder
>specialist. Our conference yesterday lasted about 4 hours including lunch
>with the doctor and his staff in the hospital cafeteria.I do a lot of
>tangential work with the doctors patients in the hospital and in his private
>support group. I mention this as a background to our medical course of
>treatment. The doctor is experimenting a little and trusts me to stay with
>the medical protocal and to report accurately the results to him. He has
>given me the freedom to increase my sinemet intake during this period to
>every 2 1/2 hours if I go into off periods until the requip loads up into my
>system.
>
>The doctor advised me that it is a very tough transition period and that I
>need to stick it out for at least six weeks. Initially I can expect to
>stiffen up significantly and to have increased periods when I am off and the
>off periods will be signifiantly longer until the requip loads up in my
>system.
>
>In the evening I attended his support meeting and Dr. Perez overheard me
>making plans for breakfast next monday with one of the SG members and over my
>shoulder he said i wouldn't wait till monday to have that breakfast.
>I hope he was jokeing or oh my God what have I gotten my self into.
>
>Actually I do not dread the experience and I am anxious to get it on.
>
>I will report the results weekly if I am able to.
>
>Is there anyone else taking requip at this accelerated pace?
>
>I also have seen dramatic results in our support group from two people taking
>this drug. One rather young woman has been confined to a wheel chair for
>about two years. She has been taking requip for about six weeks and for the
>last four weeks has not had to use the wheel chair. She got a round of
>applause when she walked into a breakfast social gathering we have between
>our monthly support meeting.
>
>The other example was of an elderly lady who had been in a nursing home for
>two years and she is well enough to return to her daughters home.
>
>
>Good luck to all who are giving this drug a try.
>
>
>Dale Severance
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>

--
Jeremy Browne - [log in to unmask]
Hampshire, UK