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		LISTSERV Archives
		PARKINSN Home
		PARKINSN November 1997, Week 4

Subject:

parkinson/antibiotics

From:

Linda Carlton <[log in to unmask]>

Reply-To:

Parkinson's Information Exchange <[log in to unmask]>

Date:

Fri, 21 Nov 1997 12:23:38 -0500

Content-Type:

text/plain

Parts/Attachments:

text/plain (92 lines)

This is a multi-part message in MIME format.
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http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9056710&form=6&db=m&Dopt=b
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<html>
<head>
<TITLE>PubMed medline query</TITLE>
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<FORM METHOD=3DPOST ACTION=3D/htbin-post/Entrez/query?db=3Dm_x>
<INPUT TYPE=3D"hidden" NAME=3D"doclistpage" VALUE=3D"1">
<strong>Other Formats:</strong> <a href=3D"/cgi-bin/Entrez/referer?/htbin=
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/PMGifs/Toolbar/citation.gif" border=3D0 align=3Dtop alt=3D"[Citation For=
mat]"></a>
<a href=3D"/cgi-bin/Entrez/referer?/htbin-post/Entrez/query%3fdb=3Dm&form=
=3D6&uid=3D9056710&Dopt=3Dl"><img src=3D"/PMGifs/Toolbar/medline.gif" bor=
der=3D0 align=3Dtop alt=3D"[MEDLINE Format]"></a>
<BR>
<strong>Links:</strong> <a href=3D"/cgi-bin/Entrez/referer?/htbin-post/En=
trez/query%3fdb=3Dm&form=3D6&uid=3D9056710&Dopt=3Dm"><img src=3D"/PMGifs/=
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<P><em>Annu Rev Neurosci</em> 1997;<strong>20:</strong>125-156  <P><h2>Th=
e role of vesicular transport proteins in synaptic transmission and neura=
l degeneration.</h2>
<P><h4>Liu Y, Edwards RH</h4>
<P>Classical neurotransmitters are synthesized in the cytoplasm, so they =
require transport into secretory vesicles for regulated exocytotic releas=
e. Previous work has identified distinct vesicular transport activities f=
or the different classical transmitters, and all depend on the H+-electro=
chemical gradient across the vesicle membrane but differ in the extent to=
 which they rely on the chemical and electrical components of this gradie=
nt. Drugs that interfere with vesicular amine transport have implicated t=
his activity in psychiatric disease. Selection for a cDNA encoding vesicu=
lar amine transport in the neurotoxin MPP+ also implicates the activity i=
n Parkinson's disease. Molecular cloning of vesicular monoamine transport=
ers shows sequence similarity to bacterial antibiotic resistance proteins=
, supporting a role for transport in detoxification and defining a novel =
mammalian gene family that now also includes a transporter for acetylchol=
ine. Current work focuses on the mechanism of transport and the role that=
 regulation of activity and its subcellular localization have in transmit=
ter release, behavior, and neural degeneration.
<P>Publication Types:<BR>
<UL>
<LI>Review
<LI>Review, academic
</UL>
<P>PMID: 9056710, UI: 97209410
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 format.
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--------------E407C5C85A8345AFE2A93B9C--

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